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Glutathione defense mechanism in liver injury: Insights from animal models

Food and chemical toxicology, 2013-10, Vol.60, p.38-44

2013

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Polymorphisms in drug-metabolizing enzymes : What is their clinical relevance and why do they exist?

American journal of human genetics, 1997-02, Vol.60 (2), p.265-271

NEBERT, D. W

1997

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Role of the aromatic hydrocarbon receptor and [ Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

Biochemical pharmacology, 2000, Vol.59 (1), p.65-85

2000

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Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo(−/−) knockout mice

Genes, brain and behavior, 2012-04, Vol.11 (3), p.269-277

2012

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P450 Genes: Structure, Evolution, and Regulation

Annual review of biochemistry, 1987-01, Vol.56 (1), p.945-993

1987

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Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist?

Clinical genetics, 1999-10, Vol.56 (4), p.247-258

Nebert, Daniel W

1999

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Knockout of the Mouse Glutamate Cysteine Ligase Catalytic Subunit (Gclc) Gene: Embryonic Lethal When Homozygous, and Proposed Model for Moderate Glutathione Deficiency When Heterozygous

Biochemical and biophysical research communications, 2000-12, Vol.279 (2), p.324-329

2000

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Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin- Binding Ah Receptor

Science (American Association for the Advancement of Science), 1995-05, Vol.268 (5211), p.722-726

1995

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Role of Aryl Hydrocarbon Receptor-mediated Induction of the CYP1 Enzymes in Environmental Toxicity and Cancer

The Journal of biological chemistry, 2004-06, Vol.279 (23), p.23847-23850

2004

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4-Aminobiphenyl–Induced Liver and Urinary Bladder DNA Adduct Formation in Cyp1a2(–/–) and Cyp1a2(+/+) Mice

JNCI : Journal of the National Cancer Institute, 2003-08, Vol.95 (16), p.1227-1237

2003

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The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome

Developmental biology, 2006-12, Vol.300 (1), p.366-384

2006

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Drug-metabolizing enzymes in ligand-modulated transcription

Biochemical pharmacology, 1994-01, Vol.47 (1), p.25-37

Nebert, Daniel W.

1994

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Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization

Biochemical pharmacology, 1999-08, Vol.58 (3), p.525-537

1999

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Genetically altered mice to evaluate glutathione homeostasis in health and disease

Free radical biology & medicine, 2004-11, Vol.37 (10), p.1511-1526

2004

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Pharmacogenomics, ethnicity, and susceptibility genes

The pharmacogenomics journal, 2001, Vol.1 (1), p.19-22

2001

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Proposed role of drug-metabolizing enzymes : regulation of steady-state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions

Molecular endocrinology (Baltimore, Md.), 1991-09, Vol.5 (9), p.1203-1214

NEBERT, D. W

1991

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The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

DNA and cell biology, 1993-01, Vol.12 (1), p.1-51

1993

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Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents

Molecular and Cellular Biology, 1989-10, Vol.9 (10), p.4196-4203

1989

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Drug-Metabolizing Enzymes, Polymorphisms and Interindividual Response to Environmental Toxicants

Clinical chemistry and laboratory medicine, 2000-09, Vol.38 (9), p.857-861

NEBERT, Daniel W

2000

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How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress

Biochemical pharmacology, 1997-02, Vol.53 (3), p.249-254

1997

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Personalized Medicine: Temper Expectations [with Responses]

Science (American Association for the Advancement of Science), 2012-08, Vol.337 (6097), p.910-911

2012

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The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects

Critical reviews in toxicology, 1989, Vol.20 (3), p.153-174

Nebert, Daniel W.

1989

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Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

The Journal of biological chemistry, 2002-12, Vol.277 (51), p.49446-49452

2002

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Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation

Molecular and Cellular Biology, 1992-04, Vol.12 (4), p.1856-1863

1992

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Cyp1a2(- / -) Null Mutant Mice Develop Normally but Show Deficient Drug Metabolism

Proceedings of the National Academy of Sciences - PNAS, 1996-02, Vol.93 (4), p.1671-1676

1996

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Glutathione defense mechanism in liver injury: Insights from animal models

Polymorphisms in drug-metabolizing enzymes : What is their clinical relevance and why do they exist?

Role of the aromatic hydrocarbon receptor and [ Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis

Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo(−/−) knockout mice

P450 Genes: Structure, Evolution, and Regulation

Pharmacogenetics and pharmacogenomics: why is this relevant to the clinical geneticist?

Knockout of the Mouse Glutamate Cysteine Ligase Catalytic Subunit (Gclc) Gene: Embryonic Lethal When Homozygous, and Proposed Model for Moderate Glutathione Deficiency When Heterozygous

Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin- Binding Ah Receptor

Role of Aryl Hydrocarbon Receptor-mediated Induction of the CYP1 Enzymes in Environmental Toxicity and Cancer

4-Aminobiphenyl–Induced Liver and Urinary Bladder DNA Adduct Formation in Cyp1a2(–/–) and Cyp1a2(+/+) Mice

The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome

Drug-metabolizing enzymes in ligand-modulated transcription

Tissue- and cell type-specific expression of cytochrome P450 1A1 and cytochrome P450 1A2 mRNA in the mouse localized in situ hybridization

Genetically altered mice to evaluate glutathione homeostasis in health and disease

Pharmacogenomics, ethnicity, and susceptibility genes

Proposed role of drug-metabolizing enzymes : regulation of steady-state levels of the ligands that effect growth, homeostasis, differentiation, and neuroendocrine functions

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents

Drug-Metabolizing Enzymes, Polymorphisms and Interindividual Response to Environmental Toxicants

How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress

Personalized Medicine: Temper Expectations [with Responses]

The Ah Locus: Genetic Differences in Toxicity, Cancer, Mutation, and Birth Defects

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response

Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation

Cyp1a2(- / -) Null Mutant Mice Develop Normally but Show Deficient Drug Metabolism

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