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Thrombin inhibitor design

Current medicinal chemistry, 1998-08, Vol.5 (4), p.289-304

1998

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UK‐414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve‐stimulated increases in female genital blood flow in the anaesthetized rabbit

British journal of pharmacology, 2010-05, Vol.160 (1), p.51-59

2010

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EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES

The Journal of urology, 1998-06, Vol.159 (6), p.2164-2171

1998

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Effects of sildenafil, a type‐5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro

British Journal of Urology, 1997-06, Vol.79 (6), p.958-963

1997

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Bioreductive Activation of a Series of Indolequinones by Human DT-Diaphorase: Structure−Activity Relationships

Journal of medicinal chemistry, 1999-10, Vol.42 (20), p.4071-4080

1999

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Experimental models of strike-slip tectonics

Petroleum geoscience, 1995-01, Vol.1 (1), p.71-80

1995

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Endogenous neurotransmitters mediating penile erection

British Journal of Urology, 1998-03, Vol.81 (3), p.424-431

NAYLOR, A. M

1998

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Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies

British journal of pharmacology, 1996-06, Vol.118 (4), p.871-878

1996

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Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

Journal of medicinal chemistry, 1998-07, Vol.41 (15), p.2720-2731

1998

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Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction

International journal of impotence research, 1996-06, Vol.8 (2), p.47

1996

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2-Cyclopropylindoloquinones and Their Analogues as Bioreductively Activated Antitumor Agents: Structure−Activity in Vitro and Efficacy in Vivo

Journal of medicinal chemistry, 1997-07, Vol.40 (15), p.2335-2346

1997

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Prodrugs for targeting hypoxic tissues: Regiospecific elimination of aspirin from reduced indolequinones

Bioorganic & medicinal chemistry letters, 1999-01, Vol.9 (1), p.113-118

1999

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Bioreductively-activated prodrugs for targeting hypoxic tissues: Elimination of aspirin from 2-nitroimidazole derivatives

Bioorganic & medicinal chemistry letters, 1999-05, Vol.9 (9), p.1267-1272

1999

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Insights into Enzyme Function from Studies on Mutants of Dihydrofolate Reductase

Science (American Association for the Advancement of Science), 1988-03, Vol.239 (4844), p.1105-1110

1988

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Characterization of an α1D‐adrenoceptor mediating the contractile response of rat aorta to noradrenaline

British journal of pharmacology, 1995-07, Vol.115 (6), p.981-986

1995

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Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position

Journal of medicinal chemistry, 1998-08, Vol.41 (17), p.3210-3219

1998

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Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates

Journal of medicinal chemistry, 1998-11, Vol.41 (23), p.4466-4474

1998

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Activation of the micturition reflex by NK2 receptor stimulation in the anaesthetized guinea‐pig

British journal of pharmacology, 1995-07, Vol.115 (6), p.875-882

1995

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Recent advances in bioreductive drug targeting

Mini reviews in medicinal chemistry, 2001-05, Vol.1 (1), p.17-29

2001

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Fault geometries in basement-induced wrench faulting under different initial stress states

Journal of structural geology, 1986, Vol.8 (7), p.737-752

1986

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Design of Highly Potent Noncovalent Thrombin Inhibitors That Utilize a Novel Lipophilic Binding Pocket in the Thrombin Active Site

Journal of medicinal chemistry, 1997-03, Vol.40 (6), p.830-832

1997

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Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures: Rapid Structure−Activity Studies by Solid-Phase Synthesis

Journal of medicinal chemistry, 1998-03, Vol.41 (7), p.1011-1013

1998

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Human-murine chimeras of ICAM-1 identify amino acid residues critical for rhinovirus and antibody binding

Journal of Virology, 1991-12, Vol.65 (12), p.6589-6596

1991

Volltextzugriff (PDF)

4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells

Journal of medicinal chemistry, 2000-12, Vol.43 (26), p.4923-4926

2000

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Thrombin inhibitor design

UK‐414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve‐stimulated increases in female genital blood flow in the anaesthetized rabbit

EFFECTS OF SILDENAFIL ON THE RELAXATION OF HUMAN CORPUS CAVERNOSUM TISSUE IN VITRO AND ON THE ACTIVITIES OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE ISOZYMES

Effects of sildenafil, a type‐5 cGMP phosphodiesterase inhibitor, and papaverine on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro

Bioreductive Activation of a Series of Indolequinones by Human DT-Diaphorase: Structure−Activity Relationships

Experimental models of strike-slip tectonics

Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor N-(9-Hydroxy-9-fluorenecarboxy)prolyl trans-4-Aminocyclohexylmethyl Amide (L-372,460): Coapplication of Structure-Based Design and Rapid Multiple Analogue Synthesis on Solid Support

Endogenous neurotransmitters mediating penile erection

Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies

Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction

2-Cyclopropylindoloquinones and Their Analogues as Bioreductively Activated Antitumor Agents: Structure−Activity in Vitro and Efficacy in Vivo

Prodrugs for targeting hypoxic tissues: Regiospecific elimination of aspirin from reduced indolequinones

Bioreductively-activated prodrugs for targeting hypoxic tissues: Elimination of aspirin from 2-nitroimidazole derivatives

Insights into Enzyme Function from Studies on Mutants of Dihydrofolate Reductase

Characterization of an α1D‐adrenoceptor mediating the contractile response of rat aorta to noradrenaline

Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position

Efficacious, Orally Bioavailable Thrombin Inhibitors Based on 3-Aminopyridinone or 3-Aminopyrazinone Acetamide Peptidomimetic Templates

Activation of the micturition reflex by NK2 receptor stimulation in the anaesthetized guinea‐pig

Recent advances in bioreductive drug targeting

Fault geometries in basement-induced wrench faulting under different initial stress states

Design of Highly Potent Noncovalent Thrombin Inhibitors That Utilize a Novel Lipophilic Binding Pocket in the Thrombin Active Site

Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures: Rapid Structure−Activity Studies by Solid-Phase Synthesis

Human-murine chimeras of ICAM-1 identify amino acid residues critical for rhinovirus and antibody binding

4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells

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