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State of the art in African trypanosome drug discovery

Current topics in medicinal chemistry, 2011-05, Vol.11 (10), p.1255-1274

2011

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SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis

PLoS neglected tropical diseases, 2011-06, Vol.5 (6), p.e1151

2011

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Targeting Lysine Deacetylases (KDACs) in Parasites

PLoS neglected tropical diseases, 2015-09, Vol.9 (9), p.e0004026

2015

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Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

Antimicrobial Agents and Chemotherapy, 2010-10, Vol.54 (10), p.4379-4388

2010

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Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis

Parasitology, 2014-01, Vol.141 (1), p.104-118

2014

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Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats

Parasites & vectors, 2017-07, Vol.10 (1), p.341-341, Article 341

2017

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MK-4815, a Potential New Oral Agent for Treatment of Malaria

Antimicrobial Agents and Chemotherapy, 2012-05, Vol.56 (5), p.2414-2419

2012

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2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach

PLoS neglected tropical diseases, 2011-02, Vol.5 (2), p.e956

2011

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Toxoplasma gondii Cyclic GMP-Dependent Kinase: Chemotherapeutic Targeting of an Essential Parasite Protein Kinase

Eukaryotic Cell, 2002-06, Vol.1 (3), p.317-328

2002

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The Roles of Pteridine Reductase 1 and Dihydrofolate Reductase-Thymidylate Synthase in Pteridine Metabolism in the Protozoan Parasite Leishmania major

The Journal of biological chemistry, 1997-05, Vol.272 (21), p.13883-13891

1997

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DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Journal of medicinal chemistry, 2021-11, Vol.64 (21), p.16159-16176

2021

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Highly Substituted Terphenyls as Inhibitors of Parasite cGMP-Dependent Protein Kinase Activity

Journal of natural products (Washington, D.C.), 2006-04, Vol.69 (4), p.710-712

2006

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Evaluation of a Cyclic GMP-Dependent Protein Kinase Inhibitor in Treatment of Murine Toxoplasmosis: Gamma Interferon Is Required for Efficacy

Antimicrobial Agents and Chemotherapy, 2002-02, Vol.46 (2), p.300-307

2002

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Chalcone–Benzoxaborole Hybrid Molecules as Potent Antitrypanosomal Agents

Journal of medicinal chemistry, 2012-04, Vol.55 (7), p.3553-3557

2012

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PTR1: A Reductase Mediating Salvage of Oxidized Pteridines and Methotrexate Resistance in the Protozoan Parasite Leishmania major

Proceedings of the National Academy of Sciences - PNAS, 1994-11, Vol.91 (24), p.11442-11446

1994

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Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

Bioorganic & medicinal chemistry letters, 2018-01, Vol.28 (1), p.6-10

2018

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Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human African trypanosomiasis

International journal for parasitology -- drugs and drug resistance, 2012-12, Vol.2, p.262-270

2012

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Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei

European journal of medicinal chemistry, 2014-06, Vol.81, p.59-75

2014

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Design, Synthesis, and Structure−Activity Relationship of Trypanosoma brucei Leucyl-tRNA Synthetase Inhibitors as Antitrypanosomal Agents

Journal of medicinal chemistry, 2011-03, Vol.54 (5), p.1276-1287

2011

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Targeting Lysine Deacetylases (KDACs) in Parasites: e0004026

PLoS neglected tropical diseases, 2015-09, Vol.9 (9)

2015

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Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis

Future medicinal chemistry, 2011-08, Vol.3 (10), p.1259-1278

2011

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Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents

ACS medicinal chemistry letters, 2010-07, Vol.1 (4), p.165-169

2010

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Anticoccidial kinase inhibitors: Identification of protein kinase targets secondary to cGMP-dependent protein kinase

Molecular and biochemical parasitology, 2006-09, Vol.149 (1), p.86-98

2006

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PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major

Current genetics, 2009-06, Vol.55 (3), p.287-299

2009

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NITROPHENIDE (MEGASUL™) BLOCKS EIMERIA TENELLA DEVELOPMENT BY INHIBITING THE MANNITOL CYCLE ENZYME MANNITOL-1-PHOSPHATE DEHYDROGENASE

The Journal of parasitology, 2001-12, Vol.87 (6), p.1441-1448

2001

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State of the art in African trypanosome drug discovery

SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis

Targeting Lysine Deacetylases (KDACs) in Parasites

Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis

Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats

MK-4815, a Potential New Oral Agent for Treatment of Malaria

2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach

Toxoplasma gondii Cyclic GMP-Dependent Kinase: Chemotherapeutic Targeting of an Essential Parasite Protein Kinase

The Roles of Pteridine Reductase 1 and Dihydrofolate Reductase-Thymidylate Synthase in Pteridine Metabolism in the Protozoan Parasite Leishmania major

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

Highly Substituted Terphenyls as Inhibitors of Parasite cGMP-Dependent Protein Kinase Activity

Evaluation of a Cyclic GMP-Dependent Protein Kinase Inhibitor in Treatment of Murine Toxoplasmosis: Gamma Interferon Is Required for Efficacy

Chalcone–Benzoxaborole Hybrid Molecules as Potent Antitrypanosomal Agents

PTR1: A Reductase Mediating Salvage of Oxidized Pteridines and Methotrexate Resistance in the Protozoan Parasite Leishmania major

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human African trypanosomiasis

Novel pyrrolobenzoxaboroles: Design, synthesis, and biological evaluation against Trypanosoma brucei

Design, Synthesis, and Structure−Activity Relationship of Trypanosoma brucei Leucyl-tRNA Synthetase Inhibitors as Antitrypanosomal Agents

Targeting Lysine Deacetylases (KDACs) in Parasites: e0004026

Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis

Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents

Anticoccidial kinase inhibitors: Identification of protein kinase targets secondary to cGMP-dependent protein kinase

PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major

NITROPHENIDE (MEGASUL™) BLOCKS EIMERIA TENELLA DEVELOPMENT BY INHIBITING THE MANNITOL CYCLE ENZYME MANNITOL-1-PHOSPHATE DEHYDROGENASE

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