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Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity

Molecules (Basel, Switzerland), 2020-06, Vol.25 (12), p.2843

2020

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Design of a New α-1- C -Alkyl-DAB Derivative Acting as a Pharmacological Chaperone for β-Glucocerebrosidase Using Ligand Docking and Molecular Dynamics Simulation

Molecules (Basel, Switzerland), 2018-10, Vol.23 (10), p.2683

2018

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Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease

Organic & biomolecular chemistry, 2016-01, Vol.14 (3), p.1039-1048

2016

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Three-Dimensional Quantitative Structure–Activity Relationship Analysis for Human Pregnane X Receptor for the Prediction of CYP3A4 Induction in Human Hepatocytes: Structure-Based Comparative Molecular Field Analysis

Journal of pharmaceutical sciences, 2015-01, Vol.104 (1), p.223-232

2015

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Three-dimensional Quantitative Structure–Activity Relationship Analysis of Inhibitors of Human and Rat Cytochrome P4503A Enzymes

DRUG METABOLISM AND PHARMACOKINETICS, 2013, Vol.28 (4), p.345-355

2013

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Multi-step virtual screening to develop selective DYRK1A inhibitors

Journal of molecular graphics & modelling, 2017-03, Vol.72, p.229-239

2017

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In silico study on the inhibitory interaction of drugs with wild-type CYP2D6.1 and the natural variant CYP2D6.17

Drug metabolism and pharmacokinetics, 2014, Vol.29 (1), p.52-60

2014

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The Antiviral Drug Acyclovir Is a Slow-Binding Inhibitor of d‑Amino Acid Oxidase

Biochemistry (Easton), 2013-08, Vol.52 (33), p.5665-5674

2013

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In Silico Study on the Inhibitory Interaction of Drugs with Wild-type CYP2D6.1 and the Natural Variant CYP2D6.17

DRUG METABOLISM AND PHARMACOKINETICS, 2014-02, Vol.29 (1), p.52-60

2014

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Thiolactomycin inhibits d-aspartate oxidase: A novel approach to probing the active site environment

Biochimie, 2010-10, Vol.92 (10), p.1371-1378

2010

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Estimation of the three-dimensional pharmacophore of ligands for rat multidrug-resistance-associated protein 2 using ligand-based drug design techniques

Pharmaceutical research, 2005-02, Vol.22 (2), p.260-269

2005

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Characterizing the selectivity of ER α-glucosidase inhibitors

Glycobiology (Oxford), 2019-07, Vol.29 (7), p.530-542

2019

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Design and Pharmacological Chaperone Effects of N‑(4′-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α‑Glucosidase

Journal of medicinal chemistry, 2023-07, Vol.66 (13), p.9023-9039

2023

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Comparison of Reliability of log P Values for Drugs Calculated by Several Methods

Chemical and Pharmaceutical Bulletin, 1994/04/15, Vol.42(4), pp.976-978

1994

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5‑C‑Branched Deoxynojirimycin: Strategy for Designing a 1‑Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2329-2341

2022

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Simple Method of Calculating Octanol/Water Partition Coefficient

Chemical and Pharmaceutical Bulletin, 1992/01/25, Vol.40(1), pp.127-130

1992

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Introduction of -alkyl branches to -iminosugars changes their active site binding orientation

Organic & biomolecular chemistry, 2022-09, Vol.2 (36), p.725-726

2022

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α‑1‑C‑Butyl-1,4-dideoxy-1,4-imino‑l‑arabinitol as a Second-Generation Iminosugar-Based Oral α‑Glucosidase Inhibitor for Improving Postprandial Hyperglycemia

Journal of medicinal chemistry, 2012-12, Vol.55 (23), p.10347-10362

2012

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Inhibition of adenosine deaminase (ADA)‐mediated metabolism of cordycepin by natural substances

Pharmacology research & perspectives, 2015-03, Vol.3 (2), p.e00121-n/a

2015

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Introduction of C -alkyl branches to l -iminosugars changes their active site binding orientation

Organic & biomolecular chemistry, 2022-09, Vol.20 (36), p.7250-7260

2022

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Genistein and daidzein, typical soy isoflavones, inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes

Molecular nutrition & food research, 2012-12, Vol.56 (12), p.1783-1793

2012

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Identifying Inhibitors of USP7-HDM2 Protein-Protein Interaction (PPI) by the in Silico Fragment-mapping Method

YAKUGAKU ZASSHI, 2019/05/01, Vol.139(5), pp.827-835

2019

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In silico analyses of the effects of a point mutation and a pharmacological chaperone on the thermal fluctuation of phenylalanine hydroxylase

Biophysical chemistry, 2017-09, Vol.228, p.47-54

2017

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Design and Synthesis of Labystegines, Hybrid Iminosugars from LAB and Calystegine, as Inhibitors of Intestinal α‑Glucosidases: Binding Conformation and Interaction for ntSI

Journal of organic chemistry, 2015-05, Vol.80 (9), p.4501-4515

2015

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Identifying Inhibitors of USP7-HDM2 Protein-Protein Interaction (PPI) by the in silico Fragment-Mapping Method

YAKUGAKU ZASSHI, 2019, pp.19-00006

2019

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Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity

Design of a New α-1- C -Alkyl-DAB Derivative Acting as a Pharmacological Chaperone for β-Glucocerebrosidase Using Ligand Docking and Molecular Dynamics Simulation

Docking study and biological evaluation of pyrrolidine-based iminosugars as pharmacological chaperones for Gaucher disease

Three-Dimensional Quantitative Structure–Activity Relationship Analysis for Human Pregnane X Receptor for the Prediction of CYP3A4 Induction in Human Hepatocytes: Structure-Based Comparative Molecular Field Analysis

Three-dimensional Quantitative Structure–Activity Relationship Analysis of Inhibitors of Human and Rat Cytochrome P4503A Enzymes

Multi-step virtual screening to develop selective DYRK1A inhibitors

In silico study on the inhibitory interaction of drugs with wild-type CYP2D6.1 and the natural variant CYP2D6.17

The Antiviral Drug Acyclovir Is a Slow-Binding Inhibitor of d‑Amino Acid Oxidase

In Silico Study on the Inhibitory Interaction of Drugs with Wild-type CYP2D6.1 and the Natural Variant CYP2D6.17

Thiolactomycin inhibits d-aspartate oxidase: A novel approach to probing the active site environment

Estimation of the three-dimensional pharmacophore of ligands for rat multidrug-resistance-associated protein 2 using ligand-based drug design techniques

Characterizing the selectivity of ER α-glucosidase inhibitors

Design and Pharmacological Chaperone Effects of N‑(4′-Phenylbutyl)-DAB Derivatives Targeting the Lipophilic Pocket of Lysosomal Acid α‑Glucosidase

Comparison of Reliability of log P Values for Drugs Calculated by Several Methods

5‑C‑Branched Deoxynojirimycin: Strategy for Designing a 1‑Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease

Simple Method of Calculating Octanol/Water Partition Coefficient

Introduction of -alkyl branches to -iminosugars changes their active site binding orientation

α‑1‑C‑Butyl-1,4-dideoxy-1,4-imino‑l‑arabinitol as a Second-Generation Iminosugar-Based Oral α‑Glucosidase Inhibitor for Improving Postprandial Hyperglycemia

Inhibition of adenosine deaminase (ADA)‐mediated metabolism of cordycepin by natural substances

Introduction of C -alkyl branches to l -iminosugars changes their active site binding orientation

Genistein and daidzein, typical soy isoflavones, inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes

Identifying Inhibitors of USP7-HDM2 Protein-Protein Interaction (PPI) by the in Silico Fragment-mapping Method

In silico analyses of the effects of a point mutation and a pharmacological chaperone on the thermal fluctuation of phenylalanine hydroxylase

Design and Synthesis of Labystegines, Hybrid Iminosugars from LAB and Calystegine, as Inhibitors of Intestinal α‑Glucosidases: Binding Conformation and Interaction for ntSI

Identifying Inhibitors of USP7-HDM2 Protein-Protein Interaction (PPI) by the in silico Fragment-Mapping Method

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