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Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation

Antioxidants & redox signaling, 2010-01, Vol.12 (1), p.39

2010

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X-Ray Crystallographic and Kinetic Studies of Human Sorbitol Dehydrogenase

Structure (London), 2003-09, Vol.11 (9), p.1071-1085

2003

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Orally-Effective, Long-Acting Sorbitol Dehydrogenase Inhibitors: Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Novel Heterocycle-Substituted Piperazino-Pyrimidines

Journal of medicinal chemistry, 2002-01, Vol.45 (2), p.511-528

2002

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Aldose reductase inhibitors: therapeutic implications for diabetic complications

Expert opinion on investigational drugs, 1999-12, Vol.8 (12), p.2095-2119

1999

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A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and Congeners

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6326-6339

2005

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A Highly Selective, Non-Hydantoin, Non-Carboxylic Acid Inhibitor of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2283-2286

2003

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A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate and its congeners

Journal of medicinal chemistry, 1991-03, Vol.34 (3), p.1011-1018

1991

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Design and synthesis of a novel family of triazine-based inhibitors of sorbitol dehydrogenase with oral activity: 1-{4-[3 R,5 S-dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-[1,3,5]triazin-2-yl}-( R) ethanol

Bioorganic & medicinal chemistry, 2003-09, Vol.11 (19), p.4179-4188

2003

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Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain

Journal of medicinal chemistry, 1992-02, Vol.35 (3), p.457-465

1992

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Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalazineacetic acid (zopolrestat) and congeners

Journal of medicinal chemistry, 1991-01, Vol.34 (1), p.108-122

1991

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Sorbitol Dehydrogenase Inhibitors (SDIs): A New Potent, Enantiomeric SDI, 4-[2-1R-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic Acid Dimethylamide

Journal of medicinal chemistry, 2001-08, Vol.44 (17), p.2695-2700

2001

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A Sorbitol Dehydrogenase Inhibitor of Exceptional in Vivo Potency with a Long Duration of Action: 1-(R)-{4-[4-(4,6-Dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl}ethanol

Journal of medicinal chemistry, 2002-09, Vol.45 (20), p.4398-4401

2002

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Cyclopentanone synthesis by intramolecular carbon-hydrogen insertion of diazo ketones. A diterpene-to-steroid skeleton conversion

Journal of organic chemistry, 1982-08, Vol.47 (17), p.3242-3247

1982

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Lipophilic 1,3-xylyl-21-crown-6 macrocyclic polyether 2-carboxylic acids as biological mimics of the ionophore antibiotics

Journal of medicinal chemistry, 1990-02, Vol.33 (2), p.765-771

1990

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Iodohydrins and tetrahydrofurans from lead tetraacetate-iodine oxidation of terpenic alcohols

Journal of organic chemistry, 1986-05, Vol.51 (9), p.1505-1509

1986

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Pyridine-induced solvent shifts in the nuclear magnetic resonance spectra of hydroxylic compounds

Journal of the American Chemical Society, 1968-09, Vol.90 (20), p.5480-5486

1968

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Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives

Journal of medicinal chemistry, 1992-06, Vol.35 (12), p.2155-2162

1992

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Reformatsky reaction: carboxymethylenation of cyclic anhydrides and reactions of products thereof

Journal of organic chemistry, 1991-03, Vol.56 (7), p.2587-2589

1991

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Intramolecular, Long-Range Oxidations at Saturated Carbon Centers

Journal of the American Chemical Society, 1967-01, Vol.89 (1), p.174-176

1967

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Anticoccidial derivatives of 6-azauracil. 1. Enhancement of activity by benzylation of nitrogen-1. Observations on the design of nucleotide analogs in chemotherapy

Journal of medicinal chemistry, 1977-04, Vol.20 (4), p.475-483

1977

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1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with anti-inflammatory activity

Journal of medicinal chemistry, 1990-07, Vol.33 (7), p.2019-2024

1990

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A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2 H -pyridazin-3-one and Congeners

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6326-6339

2005

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Design and synthesis of a novel family of triazine-based inhibitors of sorbitol dehydrogenase with oral activity: 1-[4-[3R,5S-dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-[1,3,5]triazin-2-yl]-(R) ethanol

Bioorganic & medicinal chemistry, 2003-09, Vol.11 (19), p.4179-4188

2003

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A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol

Journal of medicinal chemistry, 2002-09, Vol.45 (20), p.4398-4401

2002

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5-Isodehydroabietic Lactones1

Journal of organic chemistry, 1965-12, Vol.30 (12), p.4387-4388

1965

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Early neural and vascular dysfunctions in diabetic rats are largely sequelae of increased sorbitol oxidation

X-Ray Crystallographic and Kinetic Studies of Human Sorbitol Dehydrogenase

Orally-Effective, Long-Acting Sorbitol Dehydrogenase Inhibitors: Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Novel Heterocycle-Substituted Piperazino-Pyrimidines

Aldose reductase inhibitors: therapeutic implications for diabetic complications

A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and Congeners

A Highly Selective, Non-Hydantoin, Non-Carboxylic Acid Inhibitor of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one

A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate and its congeners

Design and synthesis of a novel family of triazine-based inhibitors of sorbitol dehydrogenase with oral activity: 1-{4-[3 R,5 S-dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-[1,3,5]triazin-2-yl}-( R) ethanol

Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain

Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalazineacetic acid (zopolrestat) and congeners

Sorbitol Dehydrogenase Inhibitors (SDIs): A New Potent, Enantiomeric SDI, 4-[2-1R-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic Acid Dimethylamide

A Sorbitol Dehydrogenase Inhibitor of Exceptional in Vivo Potency with a Long Duration of Action: 1-(R)-{4-[4-(4,6-Dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl}ethanol

Cyclopentanone synthesis by intramolecular carbon-hydrogen insertion of diazo ketones. A diterpene-to-steroid skeleton conversion

Lipophilic 1,3-xylyl-21-crown-6 macrocyclic polyether 2-carboxylic acids as biological mimics of the ionophore antibiotics

Iodohydrins and tetrahydrofurans from lead tetraacetate-iodine oxidation of terpenic alcohols

Pyridine-induced solvent shifts in the nuclear magnetic resonance spectra of hydroxylic compounds

Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives

Reformatsky reaction: carboxymethylenation of cyclic anhydrides and reactions of products thereof

Intramolecular, Long-Range Oxidations at Saturated Carbon Centers

Anticoccidial derivatives of 6-azauracil. 1. Enhancement of activity by benzylation of nitrogen-1. Observations on the design of nucleotide analogs in chemotherapy

1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with anti-inflammatory activity

A Novel Series of Non-Carboxylic Acid, Non-Hydantoin Inhibitors of Aldose Reductase with Potent Oral Activity in Diabetic Rat Models: 6-(5-Chloro-3-methylbenzofuran-2-sulfonyl)-2 H -pyridazin-3-one and Congeners

Design and synthesis of a novel family of triazine-based inhibitors of sorbitol dehydrogenase with oral activity: 1-[4-[3R,5S-dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-[1,3,5]triazin-2-yl]-(R) ethanol

A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol

5-Isodehydroabietic Lactones1

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