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Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.1770-1785

2022

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Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor

Acta crystallographica. Section F, Structural biology communications, 2016-02, Vol.72 (2), p.129-134

2016

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Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability

Bioorganic & medicinal chemistry letters, 2019-10, Vol.29 (19), p.126604-126604, Article 126604

2019

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Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7), p.1635-1642

2015

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Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors

Biochemistry (Easton), 2009-03, Vol.48 (12), p.2661-2674

2009

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Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker

Journal of medicinal chemistry, 2017-02, Vol.60 (3), p.1060-1075

2017

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Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors

Bioorganic & medicinal chemistry letters, 2018-04, Vol.28 (6), p.987-992

2018

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Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (4), p.126949, Article 126949

2020

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Macrocyclic factor XIa inhibitors

Bioorganic & medicinal chemistry letters, 2017-09, Vol.27 (17), p.4056-4060

2017

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Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (16), p.3833-3839

2017

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Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group

Bioorganic & medicinal chemistry, 2016-05, Vol.24 (10), p.2257-2272

2016

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Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)‑one as the P2′ Moiety

ACS medicinal chemistry letters, 2015-05, Vol.6 (5), p.590-595

2015

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Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.7226-7242

2020

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Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (21), p.127495-127495, Article 127495

2020

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Essentiality, Expression, and Characterization of the Class II 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase ofStaphylococcus aureus

Journal of Bacteriology, 2000-09, Vol.182 (18), p.5147

2000

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Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus

Journal of bacteriology, 2000-09, Vol.182 (18), p.5147-5152

2000

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Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group

Bioorganic & medicinal chemistry, 2016-05, Vol.24 (10)

2016

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Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7)

2015

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Physical contributors to glenohumeral internal rotation deficit in high school baseball players

Journal of sport and health science, 2015-09, Vol.4 (3), p.299-306

2015

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The Future of Policing: A Practical Guide for Police Managers and Leaders

Schafer, Joseph A.

1st edition., 2012

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Dynamic GABAergic afferent modulation of AgRP neurons

Nature neuroscience, 2016-12, Vol.19 (12), p.1628

2016

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Measurement of Blood Pressure in Humans: A Scientific Statement From the American Heart Association

Hypertension (Dallas, Tex. 1979), 2019-05, Vol.73 (5), p.e35-e66

2019

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Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells

PLoS biology, 2007-03, Vol.5 (3), p.e64-e64

2007

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Heart rate variability in epilepsy: A potential biomarker of sudden unexpected death in epilepsy risk

Epilepsia (Copenhagen), 2018-07, Vol.59 (7), p.1372-1380

2018

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Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor

Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability

Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties

Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors

Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups

Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker

Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors

Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa

Macrocyclic factor XIa inhibitors

Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency

Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group

Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)‑one as the P2′ Moiety

Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species

Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies

Essentiality, Expression, and Characterization of the Class II 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase ofStaphylococcus aureus

Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus

Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group

Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties

Physical contributors to glenohumeral internal rotation deficit in high school baseball players

The Future of Policing: A Practical Guide for Police Managers and Leaders

Dynamic GABAergic afferent modulation of AgRP neurons

Measurement of Blood Pressure in Humans: A Scientific Statement From the American Heart Association

Als3 is a Candida albicans invasin that binds to cadherins and induces endocytosis by host cells

Heart rate variability in epilepsy: A potential biomarker of sudden unexpected death in epilepsy risk

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