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The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery

Angewandte Chemie (International ed.), 2014-08, Vol.53 (34), p.8840-8869

International ed. in English, 2014

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Development of a platform for the discovery and practical synthesis of new tetracycline antibiotics

Current opinion in chemical biology, 2016-06, Vol.32, p.48-57

2016

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A synthetic antibiotic class overcoming bacterial multidrug resistance

Nature (London), 2021-11, Vol.599 (7885), p.507-512

2021

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A platform for the discovery of new macrolide antibiotics

Nature (London), 2016-05, Vol.533 (7603), p.338-345

2016

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A Versatile Synthesis of Substituted Isoquinolines

Angewandte Chemie (International ed.), 2011-10, Vol.50 (44), p.10409-10413

International ed. in English, 2011

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Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR

Nucleic acids research, 2023-05, Vol.51 (9), p.4536

2023

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Development of a Decarboxylative Palladation Reaction and Its Use in a Heck-type Olefination of Arene Carboxylates

Journal of the American Chemical Society, 2002-09, Vol.124 (38), p.11250-11251

2002

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Enantioselective Synthesis of Stephacidin B

Journal of the American Chemical Society, 2005-04, Vol.127 (15), p.5342-5344

2005

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Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics

Science (American Association for the Advancement of Science), 2005-04, Vol.308 (5720), p.395-398

2005

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Methodological advances permit the stereocontrolled construction of diverse fully synthetic tetracyclines containing an all-carbon quaternary center at position C5a

Tetrahedron, 2011-12, Vol.67 (51), p.9853-9869

2011

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Discovery of Macrolide Antibiotics Effective against Multi-Drug Resistant Gram-Negative Pathogens

Accounts of chemical research, 2021-04, Vol.54 (7), p.1635-1645

2021

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multiply convergent platform for the synthesis of trioxacarcins

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (17), p.6709-6714

2011

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Synthetic oxepanoprolinamide iboxamycin is active against Listeria monocytogenes despite the intrinsic resistance mediated by VgaL/Lmo0919 ABCF ATPase

JAC-antimicrobial resistance, 2022-06, Vol.4 (3), p.dlac061-dlac061

2022

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Kedarcidin Chromophore: Synthesis of Its Proposed Structure and Evidence for a Stereochemical Revision

Journal of the American Chemical Society, 2007-05, Vol.129 (17), p.5381-5383

2007

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Scalable Synthesis of Enantiomerically Pure syn-2,3-Dihydroxybutyrate by Sharpless Asymmetric Dihydroxylation of p-Phenylbenzyl Crotonate

Journal of organic chemistry, 2011-10, Vol.76 (20), p.8554-8559

2011

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Synthesis of D-Desosamine and Analogs by Rapid Assembly of 3-Amino Sugars

Angewandte Chemie (International ed.), 2016-01, Vol.55 (2), p.523-527

International ed. in English, 2016

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Proposed Resolution of a Mechanistic Puzzle of Long Duration: Self-Condensation of Cyclopentanone to Form an 11-Carbon Dienoic Acid

Journal of organic chemistry, 2023-06, Vol.88 (11), p.7557-7559

2023

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A Practical, Component-Based Synthetic Route to Methylthiolincosamine Permitting Facile Northern-Half Diversification of Lincosamide Antibiotics

Journal of the American Chemical Society, 2021-05, Vol.143 (18), p.6829-6835

2021

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[3+2] Dipolar Cycloaddition of a Stabilized Azomethine Ylide and an Electron-Deficient Dipolarophile: Revision of Regioselectivity

Journal of organic chemistry, 2023-02, Vol.88 (3), p.1907-1908

2023

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An Enantioselective, Modular, and General Route to the Cytochalasins: Synthesis of L-696,474 and Cytochalasin B

Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (33), p.12048-12053

2004

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Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic Acids, Alcohols, Aldehydes, and Ketones

Journal of the American Chemical Society, 1997-07, Vol.119 (28), p.6496-6511

1997

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Efficient, Stereoselective Synthesis of trans-2,5-Disubstituted Morpholines

Organic letters, 2004-03, Vol.6 (6), p.1045-1047

2004

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Asymmetric Synthesis of Chiral Organofluorine Compounds: Use of Nonracemic Fluoroiodoacetic Acid as a Practical Electrophile and Its Application to the Synthesis of Monofluoro Hydroxyethylene Dipeptide Isosteres within a Novel Series of HIV Protease Inhibitors

Journal of the American Chemical Society, 2001-08, Vol.123 (30), p.7207-7219

2001

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New and Stereospecific Synthesis of Allenes in a Single Step from Propargylic Alcohols

Journal of the American Chemical Society, 1996-05, Vol.118 (18), p.4492-4493

1996

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Practical Gram-Scale Synthesis of Iboxamycin, a Potent Antibiotic Candidate

Journal of the American Chemical Society, 2021-07, Vol.143 (29), p.11019-11025

2021

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The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery

Development of a platform for the discovery and practical synthesis of new tetracycline antibiotics

A synthetic antibiotic class overcoming bacterial multidrug resistance

A platform for the discovery of new macrolide antibiotics

A Versatile Synthesis of Substituted Isoquinolines

Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR

Development of a Decarboxylative Palladation Reaction and Its Use in a Heck-type Olefination of Arene Carboxylates

Enantioselective Synthesis of Stephacidin B

Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics

Methodological advances permit the stereocontrolled construction of diverse fully synthetic tetracyclines containing an all-carbon quaternary center at position C5a

Discovery of Macrolide Antibiotics Effective against Multi-Drug Resistant Gram-Negative Pathogens

multiply convergent platform for the synthesis of trioxacarcins

Synthetic oxepanoprolinamide iboxamycin is active against Listeria monocytogenes despite the intrinsic resistance mediated by VgaL/Lmo0919 ABCF ATPase

Kedarcidin Chromophore: Synthesis of Its Proposed Structure and Evidence for a Stereochemical Revision

Scalable Synthesis of Enantiomerically Pure syn-2,3-Dihydroxybutyrate by Sharpless Asymmetric Dihydroxylation of p-Phenylbenzyl Crotonate

Synthesis of D-Desosamine and Analogs by Rapid Assembly of 3-Amino Sugars

Proposed Resolution of a Mechanistic Puzzle of Long Duration: Self-Condensation of Cyclopentanone to Form an 11-Carbon Dienoic Acid

A Practical, Component-Based Synthetic Route to Methylthiolincosamine Permitting Facile Northern-Half Diversification of Lincosamide Antibiotics

[3+2] Dipolar Cycloaddition of a Stabilized Azomethine Ylide and an Electron-Deficient Dipolarophile: Revision of Regioselectivity

An Enantioselective, Modular, and General Route to the Cytochalasins: Synthesis of L-696,474 and Cytochalasin B

Pseudoephedrine as a Practical Chiral Auxiliary for the Synthesis of Highly Enantiomerically Enriched Carboxylic Acids, Alcohols, Aldehydes, and Ketones

Efficient, Stereoselective Synthesis of trans-2,5-Disubstituted Morpholines

Asymmetric Synthesis of Chiral Organofluorine Compounds: Use of Nonracemic Fluoroiodoacetic Acid as a Practical Electrophile and Its Application to the Synthesis of Monofluoro Hydroxyethylene Dipeptide Isosteres within a Novel Series of HIV Protease Inhibitors

New and Stereospecific Synthesis of Allenes in a Single Step from Propargylic Alcohols

Practical Gram-Scale Synthesis of Iboxamycin, a Potent Antibiotic Candidate

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