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Targeting of antioxidant and anti-thrombotic drugs to endothelial cell adhesion molecules

Current pharmaceutical design, 2005-01, Vol.11 (18), p.2383-2401

2005

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Targeting of superoxide dismutase and catalase to vascular endothelium

Journal of Controlled Release, 2001-03, Vol.71 (1), p.1-21

Muzykantov, Vladimir R

2001

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A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1

Journal of cell science, 2003-04, Vol.116 (Pt 8), p.1599-1609

2003

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ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs

Blood, 2005-01, Vol.105 (2), p.650-658

2005

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Lysosomal Enzyme Delivery by ICAM-1-Targeted Nanocarriers Bypassing Glycosylation- and Clathrin-Dependent Endocytosis

Molecular therapy, 2006-01, Vol.13 (1), p.135-141

2006

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Prophylactic fibrinolysis through selective dissolution of nascent clots by tPA-carrying erythrocytes

Nature biotechnology, 2003-08, Vol.21 (8), p.891-896

2003

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Polymer nanocarriers protecting active enzyme cargo against proteolysis

Journal of controlled release, 2005-02, Vol.102 (2), p.427-439

2005

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Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress

American Journal of Physiology: Cell Physiology, 2003-11, Vol.285 (5), p.C1339-C1347

2003

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Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury

Nature biotechnology, 2003-04, Vol.21 (4), p.392-398

2003

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Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins

American journal of physiology. Lung cellular and molecular physiology, 2006-05, Vol.290 (5), p.L809-L817

2006

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Blood clearance and activity of erythrocyte-coupled fibrinolytics

The Journal of pharmacology and experimental therapeutics, 2005-03, Vol.312 (3), p.1106-1113

2005

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Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature

Blood, 2005-12, Vol.106 (13), p.4191-4198

2005

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Advanced Drug Delivery Systems That Target The Vascular Endothelium

Molecular interventions, 2006-04, Vol.6 (2), p.98-112

2006

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ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface

Blood, 2003-05, Vol.101 (10), p.3977-3984

2003

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Mouse model of microembolic stroke and reperfusion

Stroke (1970), 2004-09, Vol.35 (9), p.2177-2182

2004

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Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting

American journal of physiology. Lung cellular and molecular physiology, 2001-06, Vol.280 (6), p.1335-L1347

2001

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PECAM-directed delivery of catalase to endothelium protects against pulmonary vascular oxidative stress

American journal of physiology. Lung cellular and molecular physiology, 2003-08, Vol.285 (2), p.283-L292

2003

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Streptavidin Facilitates Internalization and Pulmonary Targeting of an Anti-Endothelial Cell Antibody (Platelet-Endothelial Cell Adhesion Molecule 1): A Strategy for Vascular Immunotargeting of Drugs

Proceedings of the National Academy of Sciences - PNAS, 1999-03, Vol.96 (5), p.2379-2384

1999

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Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells

Blood, 2002-02, Vol.99 (3), p.912-922

2002

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Delivery of antioxidant enzyme proteins to the lung

Antioxidants & redox signaling, 2001-02, Vol.3 (1), p.39-62

Muzykantov, V R

2001

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Fibrin affinity of erythrocyte-coupled tissue-type plasminogen activators endures hemodynamic forces and enhances fibrinolysis in vivo

The Journal of pharmacology and experimental therapeutics, 2006-03, Vol.316 (3), p.1130-1136

2006

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Platelet-endothelial cell adhesion molecule-1-directed immunotargeting to cardiopulmonary vasculature

The Journal of pharmacology and experimental therapeutics, 2002-03, Vol.300 (3), p.777-786

2002

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Cell‐selective intracellular delivery of a foreign enzyme to endothelium in vivo using vascular immunotargeting

The FASEB journal, 2001-02, Vol.15 (2), p.416-426

2001

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Pecam-directed immunotargeting of catalase: specific, rapid and transient protection against hydrogen peroxide

Free radical biology & medicine, 2003-04, Vol.34 (8), p.1035-1046

2003

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Immunotargeting of catalase to ACE or ICAM-1 protects perfused rat lungs against oxidative stress

American journal of physiology. Lung cellular and molecular physiology, 1998-10, Vol.275 (4), p.806-L817

1998

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Targeting of antioxidant and anti-thrombotic drugs to endothelial cell adhesion molecules

Targeting of superoxide dismutase and catalase to vascular endothelium

A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1

ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs

Lysosomal Enzyme Delivery by ICAM-1-Targeted Nanocarriers Bypassing Glycosylation- and Clathrin-Dependent Endocytosis

Prophylactic fibrinolysis through selective dissolution of nascent clots by tPA-carrying erythrocytes

Polymer nanocarriers protecting active enzyme cargo against proteolysis

Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress

Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury

Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins

Blood clearance and activity of erythrocyte-coupled fibrinolytics

Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculature

Advanced Drug Delivery Systems That Target The Vascular Endothelium

ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface

Mouse model of microembolic stroke and reperfusion

Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting

PECAM-directed delivery of catalase to endothelium protects against pulmonary vascular oxidative stress

Streptavidin Facilitates Internalization and Pulmonary Targeting of an Anti-Endothelial Cell Antibody (Platelet-Endothelial Cell Adhesion Molecule 1): A Strategy for Vascular Immunotargeting of Drugs

Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells

Delivery of antioxidant enzyme proteins to the lung

Fibrin affinity of erythrocyte-coupled tissue-type plasminogen activators endures hemodynamic forces and enhances fibrinolysis in vivo

Platelet-endothelial cell adhesion molecule-1-directed immunotargeting to cardiopulmonary vasculature

Cell‐selective intracellular delivery of a foreign enzyme to endothelium in vivo using vascular immunotargeting

Pecam-directed immunotargeting of catalase: specific, rapid and transient protection against hydrogen peroxide

Immunotargeting of catalase to ACE or ICAM-1 protects perfused rat lungs against oxidative stress

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