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Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial

The Lancet (British edition), 2014-07, Vol.384 (9937), p.37-44

2014

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Immunogenicity of Elosulfase Alfa, an Enzyme Replacement Therapy in Patients With Morquio A Syndrome: Results From MOR-004, a Phase III Trial

Clinical therapeutics, 2015-05, Vol.37 (5), p.1012-1021.e6

2015

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Acetylator Status Impacts Amifampridine Phosphate (Firdapse™) Pharmacokinetics and Exposure to a Greater Extent Than Renal Function

Clinical therapeutics, 2017-07, Vol.39 (7), p.1360-1370

2017

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Nonclinical evaluation of CNS-administered TPP1 enzyme replacement in canine CLN2 neuronal ceroid lipofuscinosis

Molecular genetics and metabolism, 2015-02, Vol.114 (2), p.281-293

2015

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Effects of Food Intake on the Relative Bioavailability of Amifampridine Phosphate Salt in Healthy Adults

Clinical therapeutics, 2015-07, Vol.37 (7), p.1555-1563

2015

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Investigation of high-throughput ultrafiltration for the determination of an unbound compound in human plasma using liquid chromatography and tandem mass spectrometry with electrospray ionization

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006-10, Vol.843 (1), p.47-56

2006

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Strategies on efficient method development of on-line extraction assays for determination of MK-0974 in human plasma and urine using turbulent-flow chromatography and tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-02, Vol.863 (1), p.64-73

2008

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Reversed-phase chiral liquid chromatography on polysaccharide-based stationary phase coupled with tandem mass spectrometry for simultaneous determination of four stereoisomers of MK-0974 in human plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-10, Vol.873 (2), p.195-202

2008

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Application of a novel ultra-low elution volume 96-well solid-phase extraction method to the LC/MS/MS determination of simvastatin and simvastatin acid in human plasma

Journal of pharmaceutical and biomedical analysis, 2005-07, Vol.38 (3), p.521-527

2005

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Relative bioavailability of sapropterin from intact and dissolved sapropterin dihydrochloride tablets and the effects of food: A randomized, open-label, crossover study in healthy adults

Clinical therapeutics, 2010-02, Vol.32 (2), p.338-346

2010

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Genetic variation in aryl N‐acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4‐diaminopyridine) phosphate

Pharmacology research & perspectives, 2015-02, Vol.3 (1), p.e00099-n/a

2015

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High turbulence liquid chromatography online extraction and tandem mass spectrometry for the simultaneous determination of suberoylanilide hydroxamic acid and its two metabolites in human serum

Rapid communications in mass spectrometry, 2005-01, Vol.19 (13), p.1779-1787

2005

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A new approach for evaluating carryover and its influence on quantitation in high-performance liquid chromatography and tandem mass spectrometry assay

Rapid communications in mass spectrometry, 2006-01, Vol.20 (4), p.635-640

2006

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Pharmacokinetic and Pharmacodynamic Evaluation of Elosulfase Alfa, an Enzyme Replacement Therapy in Patients with Morquio A Syndrome

Clinical pharmacokinetics, 2014-12, Vol.53 (12), p.1137-1147

2014

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Elimination of diastereomer interference to determine Telcagepant (MK-0974) in human plasma using on-line turbulent-flow technology and off-line solid-phase extraction coupled with liquid chromatography/tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009-06, Vol.877 (16), p.1634-1642

2009

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A Prospective Population Pharmacokinetic Analysis of Sapropterin Dihydrochloride in Infants and Young Children with Phenylketonuria

Clinical pharmacokinetics, 2015-02, Vol.54 (2), p.195-207

2015

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Maternal phenylketonuria syndrome: studies in mice suggest a potential approach to a continuing problem

Pediatric research, 2018-04, Vol.83 (4), p.889-896

2018

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Concerns in the development of an assay for determination of a highly conjugated adsorption-prone compound in human urine

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-04, Vol.818 (2), p.241-248

2005

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Recombinant human tripeptidyl peptidase-1 infusion to the monkey CNS: Safety, pharmacokinetics, and distribution

Toxicology and applied pharmacology, 2014-05, Vol.277 (1), p.49-57

2014

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Assay methodology for the quantitation of unbound ertapenem, a new carbapenem antibiotic, in human plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003-01, Vol.783 (1), p.1-9

2003

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High-throughput liquid chromatography for drug analysis in biological fluids: investigation of extraction column life

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004-07, Vol.806 (2), p.177-183

2004

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Column-switching technique for the sensitive determination of ertapenem in human cerebrospinal fluid using liquid chromatography and ultraviolet absorbance detection

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004-01, Vol.799 (1), p.9-14

2004

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Pharmacokinetics of Intramuscularly Administered Ertapenem

Antimicrobial Agents and Chemotherapy, 2003-05, Vol.47 (5), p.1732-1735

2003

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Determination of sitagliptin in human urine and hemodialysate using turbulent flow online extraction and tandem mass spectrometry

Journal of pharmaceutical and biomedical analysis, 2008-02, Vol.46 (3), p.534-542

2008

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Simultaneous determination of a novel KDR kinase inhibitor and its N-oxide metabolite in human plasma using 96-well solid-phase extraction and liquid chromatography/tandem mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-03, Vol.817 (2), p.287-296

2005

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Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial

Immunogenicity of Elosulfase Alfa, an Enzyme Replacement Therapy in Patients With Morquio A Syndrome: Results From MOR-004, a Phase III Trial

Acetylator Status Impacts Amifampridine Phosphate (Firdapse™) Pharmacokinetics and Exposure to a Greater Extent Than Renal Function

Nonclinical evaluation of CNS-administered TPP1 enzyme replacement in canine CLN2 neuronal ceroid lipofuscinosis

Effects of Food Intake on the Relative Bioavailability of Amifampridine Phosphate Salt in Healthy Adults

Investigation of high-throughput ultrafiltration for the determination of an unbound compound in human plasma using liquid chromatography and tandem mass spectrometry with electrospray ionization

Strategies on efficient method development of on-line extraction assays for determination of MK-0974 in human plasma and urine using turbulent-flow chromatography and tandem mass spectrometry

Reversed-phase chiral liquid chromatography on polysaccharide-based stationary phase coupled with tandem mass spectrometry for simultaneous determination of four stereoisomers of MK-0974 in human plasma

Application of a novel ultra-low elution volume 96-well solid-phase extraction method to the LC/MS/MS determination of simvastatin and simvastatin acid in human plasma

Relative bioavailability of sapropterin from intact and dissolved sapropterin dihydrochloride tablets and the effects of food: A randomized, open-label, crossover study in healthy adults

Genetic variation in aryl N‐acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4‐diaminopyridine) phosphate

High turbulence liquid chromatography online extraction and tandem mass spectrometry for the simultaneous determination of suberoylanilide hydroxamic acid and its two metabolites in human serum

A new approach for evaluating carryover and its influence on quantitation in high-performance liquid chromatography and tandem mass spectrometry assay

Pharmacokinetic and Pharmacodynamic Evaluation of Elosulfase Alfa, an Enzyme Replacement Therapy in Patients with Morquio A Syndrome

Elimination of diastereomer interference to determine Telcagepant (MK-0974) in human plasma using on-line turbulent-flow technology and off-line solid-phase extraction coupled with liquid chromatography/tandem mass spectrometry

A Prospective Population Pharmacokinetic Analysis of Sapropterin Dihydrochloride in Infants and Young Children with Phenylketonuria

Maternal phenylketonuria syndrome: studies in mice suggest a potential approach to a continuing problem

Concerns in the development of an assay for determination of a highly conjugated adsorption-prone compound in human urine

Recombinant human tripeptidyl peptidase-1 infusion to the monkey CNS: Safety, pharmacokinetics, and distribution

Assay methodology for the quantitation of unbound ertapenem, a new carbapenem antibiotic, in human plasma

High-throughput liquid chromatography for drug analysis in biological fluids: investigation of extraction column life

Column-switching technique for the sensitive determination of ertapenem in human cerebrospinal fluid using liquid chromatography and ultraviolet absorbance detection

Pharmacokinetics of Intramuscularly Administered Ertapenem

Determination of sitagliptin in human urine and hemodialysate using turbulent flow online extraction and tandem mass spectrometry

Simultaneous determination of a novel KDR kinase inhibitor and its N-oxide metabolite in human plasma using 96-well solid-phase extraction and liquid chromatography/tandem mass spectrometry

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