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Autoimmunity checkpoints as therapeutic targets in B cell malignancies

Nature reviews. Cancer, 2018-02, Vol.18 (2), p.103-116

Müschen, Markus

2018

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Metabolic gatekeepers to safeguard against autoimmunity and oncogenic B cell transformation

Nature reviews. Immunology, 2019-05, Vol.19 (5), p.337-348

Müschen, Markus

2019

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Extrafollicular CD4 + T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease

Nature communications, 2017-10, Vol.8 (1), p.978-17, Article 978

2017

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Origins of the human B-cell lineage

Blood, 2019-09, Vol.134 (13), p.998-999

Müschen, Markus

2019

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Core transcriptional regulatory circuitries in cancer

Oncogene, 2020-10, Vol.39 (43), p.6633-6646

2020

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Portending death in germinal centers -- when B cells know their time is up

Cell research, 2018-01, Vol.28 (1), p.5-6

2018

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Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Cancer cell, 2020-07, Vol.38 (1), p.79-96.e11

2020

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Rationale for targeting the pre–B-cell receptor signaling pathway in acute lymphoblastic leukemia

Blood, 2015-06, Vol.125 (24), p.3688-3693

Müschen, Markus

2015

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Autoimmunity Checkpoints As Therapeutic Targets in B-Cell Malignancies

Blood, 2018-11, Vol.132 (Supplement 1), p.1587-1587

2018

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Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia

Nature immunology, 2015-07, Vol.16 (7), p.766-774

2015

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SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies

Cellular signalling, 2022-06, Vol.94, p.110331-110331, Article 110331

2022

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CD25 (IL2RA) Orchestrates Negative Feedback Control and Stabilizes Oncogenic Signaling Strength in Acute Lymphoblastic Leukemia

Blood, 2015-12, Vol.126 (23), p.1434-1434

2015

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Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses

Nature communications, 2021-11, Vol.12 (1), p.6522-6522, Article 6522

2021

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Metabolic Gatekeepers of Pathological B Cell Activation

Annual review of pathology, 2021-01, Vol.16 (1), p.323-349

2021

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High-resolution characterization of gene function using single-cell CRISPR tiling screen

Nature communications, 2021-07, Vol.12 (1), p.4063-4063, Article 4063

2021

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Chemical choreography of germinal center B-cell migration

Cell research, 2019-07, Vol.29 (7), p.514-515

2019

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Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1 + pre-B ALL

The Journal of experimental medicine, 2017-03, Vol.214 (3), p.793-814

2017

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B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies

Cell, 2018-04, Vol.173 (2), p.470-484.e18

2018

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Metabolic determinants of B-cell selection

Biochemical Society transactions, 2021-06, Vol.49 (3), p.1467-1478

2021

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Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK

Blood, 2017-03, Vol.129 (9), p.1155-1165

2017

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Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia

Nature communications, 2021-06, Vol.12 (1), p.3526-3526, Article 3526

2021

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PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

Nature medicine, 2016-04, Vol.22 (4), p.379-387

2016

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Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells

Cell reports (Cambridge), 2018-06, Vol.23 (11), p.3127-3136

2018

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Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival

Nature immunology, 2017-06, Vol.18 (6), p.694-704

2017

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Autoimmunity checkpoints as therapeutic targets in B cell malignancies

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

Metabolic gatekeepers to safeguard against autoimmunity and oncogenic B cell transformation

Extrafollicular CD4 + T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease

Origins of the human B-cell lineage

Core transcriptional regulatory circuitries in cancer

Portending death in germinal centers -- when B cells know their time is up

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Rationale for targeting the pre–B-cell receptor signaling pathway in acute lymphoblastic leukemia

Autoimmunity Checkpoints As Therapeutic Targets in B-Cell Malignancies

Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia

SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies

CD25 (IL2RA) Orchestrates Negative Feedback Control and Stabilizes Oncogenic Signaling Strength in Acute Lymphoblastic Leukemia

Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses

Metabolic Gatekeepers of Pathological B Cell Activation

High-resolution characterization of gene function using single-cell CRISPR tiling screen

Chemical choreography of germinal center B-cell migration

Genetic analysis of Ikaros target genes and tumor suppressor function in BCR-ABL1 + pre-B ALL

B-Cell-Specific Diversion of Glucose Carbon Utilization Reveals a Unique Vulnerability in B Cell Malignancies

Metabolic determinants of B-cell selection

Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK

Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia

PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells

Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival

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