UB Paderborn / Katalog / Suche / in CDI

Sortiert nach

Einfacher Volltextzugriff von (fast) überall

Installieren Sie die LibKey Nomad-Browsererweiterung und erhalten Sie von vielen Webseiten einfachen Zugriff auf lizenzierte Volltexte oder Open Access Publikationen. Mehr erfahren...

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12725-12747

2020

Volltextzugriff (PDF)

Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance

Molecular cancer therapeutics, 2016-10, Vol.15 (10), p.2273-2281

2016

Volltextzugriff (PDF)

TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations

Molecular cancer therapeutics, 2021-09, Vol.20 (9), p.1499-1507

2021

Volltextzugriff (PDF)

Recent progress on third generation covalent EGFR inhibitors

Bioorganic & medicinal chemistry letters, 2016-04, Vol.26 (8), p.1861-1868

2016

Volltextzugriff (PDF)

Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

Journal of medicinal chemistry, 2021-07, Vol.64 (13), p.9056-9077

2021

Volltextzugriff (PDF)

Nonclinical Antiangiogenesis and Antitumor Activities of Axitinib (AG-013736), an Oral, Potent, and Selective Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases 1, 2, 3

Clinical cancer research, 2008-11, Vol.14 (22), p.7272-7283

2008

Volltextzugriff (PDF)

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

Proceedings of the National Academy of Sciences - PNAS, 2010-05, Vol.107 (20), p.9446-9451

2010

Volltextzugriff (PDF)

Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling

Cell reports (Cambridge), 2020-02, Vol.30 (6), p.1935-1950.e8

2020

Volltextzugriff (PDF)

SP600125, An Anthrapyrazolone Inhibitor of Jun N-Terminal Kinase

Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (24), p.13681-13686

2001

Volltextzugriff (PDF)

Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility

PloS one, 2015-09, Vol.10 (9), p.e0138616

2015

Volltextzugriff (PDF)

Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer

Molecular cancer therapeutics, 2014-08, Vol.13 (8), p.2104-2115

2014

Volltextzugriff (PDF)

Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (17), p.4187-4191

2014

Volltextzugriff (PDF)

Countering Breast Cancer's Counterpunch

Molecular cancer therapeutics, 2019-10, Vol.18 (10), p.1682-1683

Murray, Brion W

2019

Volltextzugriff (PDF)

Discovery of Pyrroloaminopyrazoles as Novel PAK Inhibitors

Journal of medicinal chemistry, 2012-05, Vol.55 (10), p.4728-4739

2012

Volltextzugriff (PDF)

Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations

Molecular cancer therapeutics, 2021-12, Vol.20 (12), p.2446-2456

2021

Volltextzugriff (PDF)

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Nature (London), 2015-03, Vol.519 (7541), p.102-105

2015

Volltextzugriff (PDF)

Durability of Kinase-Directed Therapies--A Network Perspective on Response and Resistance

Molecular cancer therapeutics, 2015-09, Vol.14 (9), p.1975-1984

2015

Volltextzugriff (PDF)

Protein kinase biochemistry and drug discovery

Bioorganic chemistry, 2011-12, Vol.39 (5), p.192-210

2011

Volltextzugriff (PDF)

Analysis of Cysteine Redox Post-Translational Modifications in Cell Biology and Drug Pharmacology

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1558, p.191

2017

Volltextzugriff (PDF)

The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase

The Journal of biological chemistry, 2017-09, Vol.292 (38), p.15705-15716

2017

Volltextzugriff (PDF)

Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology

Frontiers in pharmacology, 2014-10, Vol.5, p.224-224

2014

Volltextzugriff (PDF)

Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3002-3019

2017

Volltextzugriff (PDF)

An algebraic model for the kinetics of covalent enzyme inhibition at low substrate concentrations

Analytical biochemistry, 2015-09, Vol.484, p.82-90

2015

Volltextzugriff (PDF)

1 – 25 von 88

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(83)
Mit Volltextzugriff
(84)

Publikationsform

Artikel
(87)
Tagungsberichte
(1)

Sprache

Englisch
(88)

Erscheinungsjahr

n.n

Thema

Science & Technology
(60)
Life Sciences & Biomedicine
(50)
Humans
(40)
Biochemistry & Molecular Biology
(22)
Animals
(19)
Pharmacology & Pharmacy
(16)
Chemistry
(14)
Chemistry, Medicinal
(14)
Physical Sciences
(14)
Phosphorylation
(13)
Protein Kinase Inhibitors - Pharmacology
(13)
Kinetics
(12)
Female
(11)
Models, Molecular
(10)
Protein Kinase Inhibitors - Chemistry
(10)
Biological And Medical Sciences
(9)
Oncology
(9)
Structure-Activity Relationship
(9)
Chemistry, Organic
(8)
Enzyme Inhibitors - Pharmacology
(8)

15 weitere anzeigen...

Weniger anzeigen...

Menü

Weitere Dienste

Einstellungen

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance

TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations

Recent progress on third generation covalent EGFR inhibitors

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

Nonclinical Antiangiogenesis and Antitumor Activities of Axitinib (AG-013736), an Oral, Potent, and Selective Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases 1, 2, 3

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling

SP600125, An Anthrapyrazolone Inhibitor of Jun N-Terminal Kinase

Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility

Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer

Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket

Countering Breast Cancer's Counterpunch

Discovery of Pyrroloaminopyrazoles as Novel PAK Inhibitors

Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Durability of Kinase-Directed Therapies--A Network Perspective on Response and Resistance

Protein kinase biochemistry and drug discovery

Analysis of Cysteine Redox Post-Translational Modifications in Cell Biology and Drug Pharmacology

The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase

Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology

An algebraic model for the kinetics of covalent enzyme inhibition at low substrate concentrations

Suchergebnisse filtern