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Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12725-12747

2020

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Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance

Molecular cancer therapeutics, 2016-10, Vol.15 (10), p.2273-2281

2016

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Countering Breast Cancer's Counterpunch

Molecular cancer therapeutics, 2019-10, Vol.18 (10), p.1682-1683

Murray, Brion W

2019

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Recent progress on third generation covalent EGFR inhibitors

Bioorganic & medicinal chemistry letters, 2016-04, Vol.26 (8), p.1861-1868

2016

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TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations

Molecular cancer therapeutics, 2021-09, Vol.20 (9), p.1499-1507

2021

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Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Nature (London), 2015-03, Vol.519 (7541), p.102-105

2015

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Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations

Molecular cancer therapeutics, 2021-12, Vol.20 (12), p.2446-2456

2021

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Durability of Kinase-Directed Therapies--A Network Perspective on Response and Resistance

Molecular cancer therapeutics, 2015-09, Vol.14 (9), p.1975-1984

2015

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Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

Journal of medicinal chemistry, 2021-07, Vol.64 (13), p.9056-9077

2021

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Nonclinical Antiangiogenesis and Antitumor Activities of Axitinib (AG-013736), an Oral, Potent, and Selective Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases 1, 2, 3

Clinical cancer research, 2008-11, Vol.14 (22), p.7272-7283

2008

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Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

Proceedings of the National Academy of Sciences - PNAS, 2010-05, Vol.107 (20), p.9446-9451

2010

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Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling

Cell reports (Cambridge), 2020-02, Vol.30 (6), p.1935-1950.e8

2020

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Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology

Frontiers in pharmacology, 2014-10, Vol.5, p.224-224

2014

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Protein kinase biochemistry and drug discovery

Bioorganic chemistry, 2011-12, Vol.39 (5), p.192-210

2011

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Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility

PloS one, 2015-09, Vol.10 (9), p.e0138616

2015

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Analysis of Cysteine Redox Post-Translational Modifications in Cell Biology and Drug Pharmacology

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1558, p.191

2017

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Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (45), p.18281-18289

2012

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A simple and efficient maleimide-based approach for peptide extension with a cysteine-containing peptide phage library

Bioorganic & medicinal chemistry letters, 2013-10, Vol.23 (20), p.5680-5683

2013

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The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase

The Journal of biological chemistry, 2017-09, Vol.292 (38), p.15705-15716

2017

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Discovery of N‑((3R,4R)‑4-Fluoro-1-(6-((3-methoxy-1-methyl‑1H‑pyrazol-4-yl)amino)-9-methyl‑9H‑purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3002-3019

2017

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Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer

Molecular cancer therapeutics, 2014-08, Vol.13 (8), p.2104-2115

2014

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SP600125, An Anthrapyrazolone Inhibitor of Jun N-Terminal Kinase

Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (24), p.13681-13686

2001

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An algebraic model for the kinetics of covalent enzyme inhibition at low substrate concentrations

Analytical biochemistry, 2015-09, Vol.484, p.82-90

2015

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Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance

Countering Breast Cancer's Counterpunch

Recent progress on third generation covalent EGFR inhibitors

TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations

Durability of Kinase-Directed Therapies--A Network Perspective on Response and Resistance

Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

Nonclinical Antiangiogenesis and Antitumor Activities of Axitinib (AG-013736), an Oral, Potent, and Selective Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases 1, 2, 3

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling

Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology

Protein kinase biochemistry and drug discovery

Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility

Analysis of Cysteine Redox Post-Translational Modifications in Cell Biology and Drug Pharmacology

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

A simple and efficient maleimide-based approach for peptide extension with a cysteine-containing peptide phage library

The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase

Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer

SP600125, An Anthrapyrazolone Inhibitor of Jun N-Terminal Kinase

An algebraic model for the kinetics of covalent enzyme inhibition at low substrate concentrations

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