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Notch Inhibition in Cancer: Challenges and Opportunities

Chimia, 2020-10, Vol.74 (10), p.779

2020

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Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model

The FASEB journal, 2017-07, Vol.31 (7), p.3138-3149

2017

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Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration

Journal of neuroinflammation, 2020-07, Vol.17 (1), p.1-228, Article 228

2020

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Effect of Inhibition of the Lysophosphatidic Acid Receptor 1 on Metastasis and Metastatic Dormancy in Breast Cancer

JNCI : Journal of the National Cancer Institute, 2012-09, Vol.104 (17), p.1306-1319

2012

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The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34 + Stem/Progenitor Cells

Molecular cancer therapeutics, 2017-08, Vol.16 (8), p.1497-1510

2017

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Activating Smoothened mutations in sporadic basal-cell carcinoma

Nature (London), 1998-01, Vol.391 (6662), p.90-92

1998

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Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

Journal of cell science, 1999-12, Vol.112 ( Pt 23) (23), p.4437-4448

1999

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Gli regulation by the opposing activities of Fused and Suppressor of Fused

Nature cell biology, 2000-05, Vol.2 (5), p.310-312

2000

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Abstract 5799: Characterization and profiling of CB-103, a novel small-molecule protein-protein interaction inhibitor targeting the NOTCH transcription complex

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.5799-5799

2018

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Abstract 2695: Direct targeting of NOTCH transcription complex by a novel small molecule CB-103 circumvents dose-limiting toxicities associated with pan-NOTCH inhibitors

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2695-2695

2019

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Hematopoietic Deficiencies in c‐mpl and TPO Knockout Mice

Stem cells (Dayton, Ohio), 1998-01, Vol.16 (1), p.1-6

1998

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In vitro anti‐lymphoma activity of the first‐in‐class pan‐NOTCH transcription inhibitor CB‐103

British journal of haematology, 2023-03, Vol.200 (5), p.669-672

2023

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Gene expression patterns in adenoid cystic carcinoma with and without diffuse NOTCH1 intracellular domain (NICD1) immunohistochemistry staining

Oral oncology, 2023-11, Vol.146, p.106542-106542, Article 106542

2023

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SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects

Bioorganic & medicinal chemistry, 2017-10, Vol.25 (20), p.5849-5858

2017

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Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

Cell, 2002-04, Vol.109 (1), p.47-60

2002

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Abstract 1163: Non clinical pharmacology, pharmacokinetics and safety profiling of CB-103: A novel first-in-class small molecule inhibitor of the NOTCH pathway

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1163-1163

2017

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Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis

International journal of oncology, 2012-04, Vol.40 (4), p.1133-1141

2012

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Abstract B061: Targeting lymphomas with the novel first-in-class pan-NOTCH transcription inhibitor CB-103

Molecular cancer therapeutics, 2018-01, Vol.17 (1_Supplement), p.B061-B061

2018

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Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases

Molecular cancer therapeutics, 2016-10, Vol.15 (10), p.2334-2343

2016

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Sonic hedgehog signaling by the Patched–Smoothened receptor complex

Current biology, 1999-01, Vol.9 (2), p.76-84

1999

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Abstract 1454: LPA1 regulated pathways that mediate breast cancer dormancy in the liver and lung

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.1454-1454

2011

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Abstract 5767: LPA1 antagonist, Debio 0719, acts as a metastasis suppressor in breast cancer

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.5767-5767

2010

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The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types

Nature neuroscience, 2000-01, Vol.3 (1), p.41-46

2000

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Hedgehog Signal Transduction: From Flies to Vertebrates

Experimental cell research, 1999-11, Vol.253 (1), p.25-33

1999

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fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised

The EMBO journal, 1996-12, Vol.15 (23), p.6605-6616

1996

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Notch Inhibition in Cancer: Challenges and Opportunities

Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model

Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration

Effect of Inhibition of the Lysophosphatidic Acid Receptor 1 on Metastasis and Metastatic Dormancy in Breast Cancer

The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34 + Stem/Progenitor Cells

Activating Smoothened mutations in sporadic basal-cell carcinoma

Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

Gli regulation by the opposing activities of Fused and Suppressor of Fused

Abstract 5799: Characterization and profiling of CB-103, a novel small-molecule protein-protein interaction inhibitor targeting the NOTCH transcription complex

Abstract 2695: Direct targeting of NOTCH transcription complex by a novel small molecule CB-103 circumvents dose-limiting toxicities associated with pan-NOTCH inhibitors

Hematopoietic Deficiencies in c‐mpl and TPO Knockout Mice

In vitro anti‐lymphoma activity of the first‐in‐class pan‐NOTCH transcription inhibitor CB‐103

Gene expression patterns in adenoid cystic carcinoma with and without diffuse NOTCH1 intracellular domain (NICD1) immunohistochemistry staining

SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects

Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

Abstract 1163: Non clinical pharmacology, pharmacokinetics and safety profiling of CB-103: A novel first-in-class small molecule inhibitor of the NOTCH pathway

Targeting lysophosphatidic acid receptor type 1 with Debio 0719 inhibits spontaneous metastasis dissemination of breast cancer cells independently of cell proliferation and angiogenesis

Abstract B061: Targeting lymphomas with the novel first-in-class pan-NOTCH transcription inhibitor CB-103

Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases

Sonic hedgehog signaling by the Patched–Smoothened receptor complex

Abstract 1454: LPA1 regulated pathways that mediate breast cancer dormancy in the liver and lung

Abstract 5767: LPA1 antagonist, Debio 0719, acts as a metastasis suppressor in breast cancer

The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types

Hedgehog Signal Transduction: From Flies to Vertebrates

fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised

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