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PHARMACOLOGICAL ACTIVITY OF CB‐103 IN HAEMATOLOGICAL MALIGNANCIES – AN ORAL PAN‐NOTCH INHIBITOR WITH A NOVEL MODE OF ACTION

Hematological oncology, 2017-06, Vol.35 (S2), p.46-46

2017

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fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised

The EMBO journal, 1996-12, Vol.15 (23), p.6605-6616

1996

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Abstract P4-07-05: A novel, first in class Notch transcriptional inhibitor, CB-103 has activity on luminal breast cancer stem cells in combination with fulvestrant

Cancer research (Chicago, Ill.), 2019-02, Vol.79 (4_Supplement), p.P4-P4-07-05

2019

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Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

Cell, 2002-04, Vol.109 (1), p.47-60

2002

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Pharmacological activity of CB-103: An oral pan-NOTCH inhibitor with a novel mode of action

Annals of oncology, 2017-09, Vol.28, p.v137-v137

2017

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Pharmacological activity of CB-103: An oral pan-NOTCH inhibitor targeting the NOTCH transcription complex

Annals of oncology, 2018-03, Vol.29, p.iii14-iii14

2018

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Hematopoietic Deficiencies in c‐mpl and TPO Knockout Mice

Stem cells (Dayton, Ohio), 1998-01, Vol.16 (1), p.1-6

1998

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562P Target engagement and clinical safety of CB-103, a first-in-class small molecule inhibitor of the NOTCH transcription complex

Annals of oncology, 2020-09, Vol.31, p.S484-S485

2020

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Activating Smoothened mutations in sporadic basal-cell carcinoma

Nature (London), 1998-01, Vol.391 (6662), p.90-92

1998

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Sonic hedgehog signaling by the Patched–Smoothened receptor complex

Current biology, 1999-01, Vol.9 (2), p.76-84

1999

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Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

Journal of cell science, 1999-12, Vol.112 ( Pt 23) (23), p.4437-4448

1999

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The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types

Nature neuroscience, 2000-01, Vol.3 (1), p.41-46

2000

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Gli regulation by the opposing activities of Fused and Suppressor of Fused

Nature cell biology, 2000-05, Vol.2 (5), p.310-312

2000

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Hedgehog Signal Transduction: From Flies to Vertebrates

Experimental cell research, 1999-11, Vol.253 (1), p.25-33

1999

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66PPharmacological activity of CB-103: An oral pan-NOTCH inhibitor targeting the NOTCH transcription complex

Annals of oncology, 2018-03, Vol.29 (suppl_3)

2018

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The S. pombe zfs1 gene is required to prevent septation if mitotic progression is inhibited

Journal of cell science, 1999-09, Vol.112 Pt 18 (18), p.3103-3114

1999

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Improved HPLC determination of urinary hydroxylysine glycosides to study turnover rate of bone in humans and rats

Clinical chemistry (Baltimore, Md.), 1994-11, Vol.40 (11 Pt 1), p.2113

1994

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Efficacy of Low-Dose Intermittent Subcutaneous Interleukin (IL)–2 in Antiviral Drug–Experienced Human Immunodeficiency Virus–Infected Persons with Detectable Virus Load: A Controlled Study of 3 IL-2 Regimens with Antiviral Drug Therapy

The Journal of infectious diseases, 2001-05, Vol.183 (10), p.1476-1484

2001

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Experiences in immune reconstitution. The rationale for interleukin-2 administration to HIV-infected individuals

Journal of biological regulators and homeostatic agents, 1997-01, Vol.11 (1-2), p.74

1997

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Urinary hydroxylysine glycosides : solid phase extraction and reversed phase chromatographic measurement

Chromatographia, 1993-12, Vol.36 (1), p.144-146

1993

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Performance of a modified HPLC method to determine total hydroxyprolinuria in 2-h urine samples

Clinical chemistry (Baltimore, Md.), 1992-11, Vol.38 (11), p.2337

1992

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Discordant results for lutropin among immunoassays in two cases of male hypogonadism

Clinical chemistry (Baltimore, Md.), 1990-09, Vol.36 (9), p.1689

1990

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Discrepancies among commercial kits for assaying growth hormone

Clinical chemistry (Baltimore, Md.), 1990-02, Vol.36 (2), p.402

1990

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High concentrations of tumor-associated trypsin inhibitor in hemodialyzed patients

Clinical chemistry (Baltimore, Md.), 1988-01, Vol.34 (1), p.174

1988

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"Single step" PCR with a sensitivity similar to nested PCR for the detection of hepatitis C virus RNA

Clinical and experimental rheumatology, 1995-11, Vol.13 Suppl 13, p.S59

1995

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PHARMACOLOGICAL ACTIVITY OF CB‐103 IN HAEMATOLOGICAL MALIGNANCIES – AN ORAL PAN‐NOTCH INHIBITOR WITH A NOVEL MODE OF ACTION

fission yeast dma1 gene is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised

Abstract P4-07-05: A novel, first in class Notch transcriptional inhibitor, CB-103 has activity on luminal breast cancer stem cells in combination with fulvestrant

Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

Pharmacological activity of CB-103: An oral pan-NOTCH inhibitor with a novel mode of action

Pharmacological activity of CB-103: An oral pan-NOTCH inhibitor targeting the NOTCH transcription complex

Hematopoietic Deficiencies in c‐mpl and TPO Knockout Mice

562P Target engagement and clinical safety of CB-103, a first-in-class small molecule inhibitor of the NOTCH transcription complex

Activating Smoothened mutations in sporadic basal-cell carcinoma

Sonic hedgehog signaling by the Patched–Smoothened receptor complex

Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli

The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types

Gli regulation by the opposing activities of Fused and Suppressor of Fused

Hedgehog Signal Transduction: From Flies to Vertebrates

66PPharmacological activity of CB-103: An oral pan-NOTCH inhibitor targeting the NOTCH transcription complex

The S. pombe zfs1 gene is required to prevent septation if mitotic progression is inhibited

Improved HPLC determination of urinary hydroxylysine glycosides to study turnover rate of bone in humans and rats

Efficacy of Low-Dose Intermittent Subcutaneous Interleukin (IL)–2 in Antiviral Drug–Experienced Human Immunodeficiency Virus–Infected Persons with Detectable Virus Load: A Controlled Study of 3 IL-2 Regimens with Antiviral Drug Therapy

Experiences in immune reconstitution. The rationale for interleukin-2 administration to HIV-infected individuals

Urinary hydroxylysine glycosides : solid phase extraction and reversed phase chromatographic measurement

Performance of a modified HPLC method to determine total hydroxyprolinuria in 2-h urine samples

Discordant results for lutropin among immunoassays in two cases of male hypogonadism

Discrepancies among commercial kits for assaying growth hormone

High concentrations of tumor-associated trypsin inhibitor in hemodialyzed patients

"Single step" PCR with a sensitivity similar to nested PCR for the detection of hepatitis C virus RNA

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