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Proteomics-based target identification of natural products affecting cancer metabolism

Journal of antibiotics, 2021-10, Vol.74 (10), p.639-650

2021

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Two-dimensional electrophoresis-cellular thermal shift assay (2DE-CETSA) for target identification of bioactive compounds

Methods in enzymology, 2022-01, Vol.675, p.425-437

2022

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Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA

Cell chemical biology, 2020-02, Vol.27 (2), p.186-196.e4

2020

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Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival

Scientific reports, 2016-05, Vol.6 (1), p.26521-26521, Article 26521

2016

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Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana

Scientific reports, 2021-10, Vol.11 (1), p.21109-11, Article 21109

2021

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A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell–accelerated fibroblast migration

The Journal of biological chemistry, 2019-03, Vol.294 (9), p.2988-2996

2019

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Target identification of small molecules based on chemical biology approaches

Molecular bioSystems, 2013-05, Vol.9 (5), p.897-914

2013

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Proteomic Profiling for Target Identification of Biologically Active Small Molecules Using 2D DIGE

Methods in molecular biology (Clifton, N.J.), 2019, Vol.1888, p.127

2019

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Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase

Natural product reports, 2016-05, Vol.33 (5), p.621-625

2016

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Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice

Journal of cellular and molecular medicine, 2019-09, Vol.23 (9), p.6283-6294

2019

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Methyl 3‑((6-Methoxy-1,4-dihydroindeno[1,2‑c]pyrazol-3-yl)amino)benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods

Journal of medicinal chemistry, 2015-05, Vol.58 (10), p.4230-4241

2015

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Allantopyrone A activates Keap1-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death

Journal of antibiotics, 2017-04, Vol.70 (4), p.429-434

2017

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Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics

Bioscience, biotechnology, and biochemistry, 2020-12, Vol.84 (12), p.2484-2490

2020

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Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34

Angewandte Chemie (International ed.), 2017-07, Vol.56 (28), p.8153-8157

International ed. in English, 2017

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A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition

FEBS letters, 2019-04, Vol.593 (8), p.763-776

2019

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identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (33), p.11691-11696

2008

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Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana

Scientific reports, 2020-05, Vol.10 (1), p.8691-8691, Article 8691

2020

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Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein

ACS chemical biology, 2012-05, Vol.7 (5), p.892-900

2012

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Proteomics accelerating the identification of the target molecule of bioactive small molecules

Current opinion in chemical biology, 2011-02, Vol.15 (1), p.57-65

2011

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Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Angewandte Chemie (International ed.), 2005-06, Vol.44 (23), p.3559-3562

2005

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Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry

Bio-protocol, 2020-02, Vol.10 (3), p.e3517-e3517

2020

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Terpendole E and its Derivative Inhibit STLC- and GSK-1-Resistant Eg5

Chembiochem : a European journal of chemical biology, 2014-05, Vol.15 (7), p.934-938

2014

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Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress

Heliyon, 2020-10, Vol.6 (10), p.e05200-e05200, Article e05200

2020

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Corrigendum to “Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress” [Heliyon 6 (10) (October 2020) e05200]

Heliyon, 2021-02, Vol.7 (2), p.e05907-e05907, Article e05907

2021

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Measurement of ATPase Activity of Valosin-containing Protein/p97

Bio-protocol, 2020-02, Vol.10 (3), p.e3516-e3516

2020

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Proteomics-based target identification of natural products affecting cancer metabolism

Two-dimensional electrophoresis-cellular thermal shift assay (2DE-CETSA) for target identification of bioactive compounds

Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA

Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival

Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana

A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell–accelerated fibroblast migration

Target identification of small molecules based on chemical biology approaches

Proteomic Profiling for Target Identification of Biologically Active Small Molecules Using 2D DIGE

Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase

Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice

Methyl 3‑((6-Methoxy-1,4-dihydroindeno[1,2‑c]pyrazol-3-yl)amino)benzoate (GN39482) as a Tubulin Polymerization Inhibitor Identified by MorphoBase and ChemProteoBase Profiling Methods

Allantopyrone A activates Keap1-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death

Discovery of small-molecule modulator of heterotrimeric Gi-protein by integrated phenotypic profiling and chemical proteomics

Phenotypic Identification of a Novel Autophagy Inhibitor Chemotype Targeting Lipid Kinase VPS34

A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition

identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana

Xanthohumol Impairs Autophagosome Maturation through Direct Inhibition of Valosin-Containing Protein

Proteomics accelerating the identification of the target molecule of bioactive small molecules

Photo-Cross-Linked Small-Molecule Affinity Matrix for Facilitating Forward and Reverse Chemical Genetics

Identification of Target Protein for Bio-active Small Molecule Using Photo-cross Linked Beads and MALDI-TOF Mass Spectrometry

Terpendole E and its Derivative Inhibit STLC- and GSK-1-Resistant Eg5

Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress

Corrigendum to “Interaction between goniothalamin and peroxisomal multifunctional enzyme type 2 triggering endoplasmic reticulum stress” [Heliyon 6 (10) (October 2020) e05200]

Measurement of ATPase Activity of Valosin-containing Protein/p97

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