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K858, a Novel Inhibitor of Mitotic Kinesin Eg5 and Antitumor Agent, Induces Cell Death in Cancer Cells

Cancer research (Chicago, Ill.), 2009-05, Vol.69 (9), p.3901-3909

2009

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Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation

The Journal of neuroscience, 2000-01, Vol.20 (1), p.43-50

2000

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A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models

Breast cancer research and treatment, 2007-12, Vol.106 (2), p.215-227

2007

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Synthesis and Antitumor Activity of Novel O-Carbamoylmethyloxime Derivatives of Radicicol

Journal of medicinal chemistry, 2003-06, Vol.46 (12), p.2534-2541

2003

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Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients

Journal of steroid biochemistry and molecular biology, 2003-09, Vol.86 (3), p.455-460

2003

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Neurotrophic 3,9-Bis[(alkylthio)methyl]- and -Bis(alkoxymethyl)-K-252a Derivatives

Journal of medicinal chemistry, 1997-06, Vol.40 (12), p.1863-1869

1997

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Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives

Biochemistry (Easton), 1992-12, Vol.31 (48), p.12069-12075

1992

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Stereoselective total synthesis of the glycosyl phosphatidylinositol (GPI) anchor of Trypanosoma brucei

Carbohydrate research, 1992-11, Vol.235, p.95-114

1992

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K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

Biochemical and biophysical research communications, 1987-01, Vol.142 (2), p.436-440

1987

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A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models

Molecular cancer therapeutics, 2015-11, Vol.14 (11), p.2463-2472

2015

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Synthetic studies on mitotic kinesin Eg5 inhibitors: Synthesis and structure–activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (16), p.3961-3963

2014

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Stereoselective synthesis of glycobiosyl phosphatidylinositol, a part structure of the glycosyl-phosphatidylinositol (GPI) anchor of Trypanosoma brucei

Carbohydrate research, 1992-10, Vol.234, p.75-91

1992

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Synthetic study on glycophosphatidyl inositol (GPI) anchor of trypanosoma brucei: Glycoheptaosyl core

Tetrahedron letters, 1990, Vol.31 (17), p.2439-2442

1990

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KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

Cancer research (Chicago, Ill.), 1999-06, Vol.59 (12), p.2931-2938

1999

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Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex

Blood, 2000-09, Vol.96 (6), p.2284-2291

2000

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Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555)

Cancer research (Chicago, Ill.), 1999-05, Vol.59 (10), p.2395-2401

1999

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Synthetic studies on glycophosphatidylinositol anchor: a highly efficient synthesis of glycobiosyl phosphatidylinositol through H-phosphonate approach

Tetrahedron letters, 1991, Vol.32 (1), p.101-104

1991

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Glycolipids with nonreducing end α‐mannosyl residues that have the potential to activate invariant Vα19 NKT cells

The FEBS journal, 2007-06, Vol.274 (11), p.2921-2932

2007

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Glycolipids with nonreducing end alpha -mannosyl residues that have the potential to activate invariant V alpha 19 NKT cells

The FEBS journal, 2007-06, Vol.274 (11), p.2921-2932

2007

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Mixed lineage kinase activity of indolocarbazole analogues

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (2), p.147-150

2002

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Abstract A62: A novel Eg5 inhibitor that causes mitotic arrest leading to rapid cancer cell death shows broad-spectrum antitumor activity in preclinical xenograft tumor models

Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.A62-A62

2009

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CEP-751 inhibits trk receptor tyrosine kinase activityin vitro and exhibits anti-tumor activity

International journal of cancer, 1997-08, Vol.72 (4), p.673-679

1997

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Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587)

Clinical cancer research, 1998-08, Vol.4 (8), p.1887-1898

1998

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Glycolipids with nonreducing end [alpha]-mannosyl residues that have the potential to activate invariant V[alpha]19 NKT cells

The FEBS journal, 2007-06, Vol.274 (11), p.2921

2007

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Glycolipids with nonreducing end alpha-mannosyl residues that have the potential to activate invariant Valpha19 NKT cells

The FEBS journal, 2007-06, Vol.274 (11), p.2921-2932

2007

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K858, a Novel Inhibitor of Mitotic Kinesin Eg5 and Antitumor Agent, Induces Cell Death in Cancer Cells

Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation

A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models

Synthesis and Antitumor Activity of Novel O-Carbamoylmethyloxime Derivatives of Radicicol

Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients

Neurotrophic 3,9-Bis[(alkylthio)methyl]- and -Bis(alkoxymethyl)-K-252a Derivatives

Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives

Stereoselective total synthesis of the glycosyl phosphatidylinositol (GPI) anchor of Trypanosoma brucei

K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases

A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models

Synthetic studies on mitotic kinesin Eg5 inhibitors: Synthesis and structure–activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives

Stereoselective synthesis of glycobiosyl phosphatidylinositol, a part structure of the glycosyl-phosphatidylinositol (GPI) anchor of Trypanosoma brucei

Synthetic study on glycophosphatidyl inositol (GPI) anchor of trypanosoma brucei: Glycoheptaosyl core

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules

Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex

Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555)

Synthetic studies on glycophosphatidylinositol anchor: a highly efficient synthesis of glycobiosyl phosphatidylinositol through H-phosphonate approach

Glycolipids with nonreducing end α‐mannosyl residues that have the potential to activate invariant Vα19 NKT cells

Glycolipids with nonreducing end alpha -mannosyl residues that have the potential to activate invariant V alpha 19 NKT cells

Mixed lineage kinase activity of indolocarbazole analogues

Abstract A62: A novel Eg5 inhibitor that causes mitotic arrest leading to rapid cancer cell death shows broad-spectrum antitumor activity in preclinical xenograft tumor models

CEP-751 inhibits trk receptor tyrosine kinase activityin vitro and exhibits anti-tumor activity

Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587)

Glycolipids with nonreducing end [alpha]-mannosyl residues that have the potential to activate invariant V[alpha]19 NKT cells

Glycolipids with nonreducing end alpha-mannosyl residues that have the potential to activate invariant Valpha19 NKT cells

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