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Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth

Cancer research (Chicago, Ill.), 2018-06, Vol.78 (12), p.3321-3336

2018

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LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

The Journal of cell biology, 2010-10, Vol.191 (1), p.169-185

2010

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p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

Cell research, 2011-04, Vol.21 (4), p.666-682

2011

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Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression

eLife, 2021-04, Vol.10

2021

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Optimisation of Sample Preparation from Primary Mouse Tissue to Maintain RNA Integrity for Methods Examining Translational Control

Cancers, 2023-08, Vol.15 (15), p.3985

2023

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Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target

Cell communication and signaling, 2013-08, Vol.11 (1), p.58-58, Article 58

2013

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Drug safety: reporting systems for the general public

BMJ. British medical journal (International ed.), 2012-08, Vol.345 (7871), p.8

Raine, June Munro

International edition, 2012

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MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability

Molecular and Cellular Biology, 2009-12, Vol.29 (24), p.6380-6390

2009

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Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

Cancer cell, 2011-06, Vol.19 (6), p.776-791

2011

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eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation

Nucleic acids research, 2023-02, Vol.51 (4), p.1859

2023

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Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization

Journal of cell science, 2019-05, Vol.132 (11)

2019

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Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

Cancer cell, 2024-02, Vol.42 (2), p.317-317

2024

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Polarized Cell Motility Induces Hydrogen Peroxide to Inhibit Cofilin via Cysteine Oxidation

Current biology, 2015-06, Vol.25 (11), p.1520-1525

2015

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Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

Cancer research (Chicago, Ill.), 2018-04, Vol.78 (8), p.2096-2114

2018

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Rho kinase inhibitor AT13148 blocks pancreatic ductal adenocarinoma invasion and tumor growth

Cancer research (Chicago, Ill.), 2018-04, Vol.78 (12), p.3321-3336

2018

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LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

Oncotarget, 2015-11, Vol.6 (36), p.38469-38486

2015

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Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation

Gut, 2014-03, Vol.63 (3), p.480-493

2014

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Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasion

European journal of cell biology, 2011, Vol.90 (1), p.13-25

2011

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Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock

Experimental cell research, 2004-05, Vol.295 (2), p.525-538

2004

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Drug safety: reporting systems for the general public

BMJ (Online), 2012-08, Vol.345, p.e4916

Raine, June Munro

2012

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Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation

Cancer research (Chicago, Ill.), 2009-09, Vol.69 (17), p.6773-6781

2009

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Tissue selective expression of conditionally-regulated ROCK by gene targeting to a defined locus

Genesis (New York, N.Y. : 2000), 2009-07, Vol.47 (7), p.440-446

2009

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Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres

Oncogene, 2001-06, Vol.20 (27), p.3541-3552

2001

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Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce interfollicular epidermal hyperplasia and tumor growth

Cancer cell, 2011-06, Vol.19 (6), p.776-791

2011

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Telomerase alone extends the replicative life span of human skeletal muscle cells without compromising genomic stability

Human gene therapy, 2003-10, Vol.14 (15), p.1473-1487

2003

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Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression

Optimisation of Sample Preparation from Primary Mouse Tissue to Maintain RNA Integrity for Methods Examining Translational Control

Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target

Drug safety: reporting systems for the general public

MST Kinases Monitor Actin Cytoskeletal Integrity and Signal via c-Jun N-Terminal Kinase Stress-Activated Kinase To Regulate p21Waf1/Cip1 Stability

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation

Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

Polarized Cell Motility Induces Hydrogen Peroxide to Inhibit Cofilin via Cysteine Oxidation

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

Rho kinase inhibitor AT13148 blocks pancreatic ductal adenocarinoma invasion and tumor growth

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation

Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasion

Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock

Drug safety: reporting systems for the general public

Sprouty2 Association with B-Raf Is Regulated by Phosphorylation and Kinase Conformation

Tissue selective expression of conditionally-regulated ROCK by gene targeting to a defined locus

Human fibroblast replicative senescence can occur in the absence of extensive cell division and short telomeres

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce interfollicular epidermal hyperplasia and tumor growth

Telomerase alone extends the replicative life span of human skeletal muscle cells without compromising genomic stability

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