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Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation

PloS one, 2016-10, Vol.11 (10), p.e0163006-e0163006

2016

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Arrestin-3 differentially regulates platelet GPCR subsets

Platelets (Edinburgh), 2020-07, Vol.31 (5), p.641-645

2020

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Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling

Haematologica (Roma), 2021-07, Vol.106 (7), p.1968-1978

2021

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Pharmacodynamic Comparison of Ticagrelor Monotherapy Versus Ticagrelor and Aspirin in Patients After Percutaneous Coronary Intervention: The TEMPLATE (Ticagrelor Monotherapy and Platelet Reactivity) Randomized Controlled Trial

Journal of the American Heart Association, 2020-12, Vol.9 (24), p.e016495

2020

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Arrestin Scaffolds NHERF1 to the P2Y12 Receptor to Regulate Receptor Internalization

The Journal of biological chemistry, 2012-07, Vol.287 (29), p.24505-24515

2012

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GPR56, a novel platelet collagen receptor that loves stress

Journal of thrombosis and haemostasis, 2021-08, Vol.19 (8), p.1848-1851

2021

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Molecular mechanisms of platelet P2Y12 receptor regulation

Biochemical Society transactions, 2013-02, Vol.41 (1), p.225-230

2013

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Protease-Activated Receptor 4 Variant p.Tyr157Cys Reduces Platelet Functional Responses and Alters Receptor Trafficking

Arteriosclerosis, thrombosis, and vascular biology, 2016-05, Vol.36 (5), p.952-960

2016

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ARF6-dependent regulation of P2Y receptor traffic and function in human platelets

PloS one, 2012-08, Vol.7 (8), p.e43532-e43532

2012

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An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets

Blood, 2011-11, Vol.118 (20), p.5641-5651

2011

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Regulation of P2Y₁ Receptor Traffic by Sorting Nexin 1 is Retromer Independent

Traffic (Copenhagen, Denmark), 2010-04, Vol.11 (4), p.508-519

2010

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Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor

Blood, 2016-12, Vol.128 (23), p.2717-2728

2016

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P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms

Blood, 2005-05, Vol.105 (9), p.3552-3560

2005

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Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets

Blood, 2004-09, Vol.104 (6), p.1745-1752

2004

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Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease

PloS one, 2015-12, Vol.10 (12), p.e0143913-e0143913

2015

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Ticagrelor inverse agonist activity at the P2Y12 receptor is non‐reversible versus its endogenous agonist adenosine 5´‐diphosphate

British journal of pharmacology, 2024-01, Vol.181 (1), p.21-35

2024

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Ticagrelor inverse agonist activity at the P2Y 12 receptor is non-reversible versus its endogenous agonist adenosine 5´-diphosphate

British journal of pharmacology, 2024-01, Vol.181 (1), p.21-35

2024

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Distinct Roles for Protein Kinase C Isoforms in Regulating Platelet Purinergic Receptor Function

Molecular pharmacology, 2006-09, Vol.70 (3), p.1132-1142

2006

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Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19

Journal of thrombosis and haemostasis, 2023-05, Vol.21 (5), p.1307-1321

2023

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Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors

British journal of pharmacology, 2024-10, Vol.181 (19), p.3685-3699

2024

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Difluorinated thromboxane A 2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors

British journal of pharmacology, 2024-10, Vol.181 (19), p.3685-3699

2024

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Pathophysiological consequences of receptor mistraffic: Tales from the platelet P2Y12 receptor

Molecular and cellular endocrinology, 2017-07, Vol.449, p.74-81

2017

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Endomorphin-2: a biased agonist at the μ-opioid receptor

Molecular pharmacology, 2012-08, Vol.82 (2), p.178-188

2012

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Pathophysiological consequences of receptor mistraffic: Tales from the platelet P2Y 12 receptor

Molecular and cellular endocrinology, 2017-07, Vol.449, p.74-81

2017

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Agonist‐independent internalization of metabotropic glutamate receptor 1a is arrestin‐ and clathrin‐dependent and is suppressed by receptor inverse agonists

Journal of neurochemistry, 2004-05, Vol.89 (4), p.1009-1020

2004

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Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation

Arrestin-3 differentially regulates platelet GPCR subsets

Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling

Pharmacodynamic Comparison of Ticagrelor Monotherapy Versus Ticagrelor and Aspirin in Patients After Percutaneous Coronary Intervention: The TEMPLATE (Ticagrelor Monotherapy and Platelet Reactivity) Randomized Controlled Trial

Arrestin Scaffolds NHERF1 to the P2Y12 Receptor to Regulate Receptor Internalization

GPR56, a novel platelet collagen receptor that loves stress

Molecular mechanisms of platelet P2Y12 receptor regulation

Protease-Activated Receptor 4 Variant p.Tyr157Cys Reduces Platelet Functional Responses and Alters Receptor Trafficking

ARF6-dependent regulation of P2Y receptor traffic and function in human platelets

An intact PDZ motif is essential for correct P2Y12 purinoceptor traffic in human platelets

Regulation of P2Y₁ Receptor Traffic by Sorting Nexin 1 is Retromer Independent

Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor

P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms

Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets

Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease

Ticagrelor inverse agonist activity at the P2Y12 receptor is non‐reversible versus its endogenous agonist adenosine 5´‐diphosphate

Ticagrelor inverse agonist activity at the P2Y 12 receptor is non-reversible versus its endogenous agonist adenosine 5´-diphosphate

Distinct Roles for Protein Kinase C Isoforms in Regulating Platelet Purinergic Receptor Function

Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19

Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors

Difluorinated thromboxane A 2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors

Pathophysiological consequences of receptor mistraffic: Tales from the platelet P2Y12 receptor

Endomorphin-2: a biased agonist at the μ-opioid receptor

Pathophysiological consequences of receptor mistraffic: Tales from the platelet P2Y 12 receptor

Agonist‐independent internalization of metabotropic glutamate receptor 1a is arrestin‐ and clathrin‐dependent and is suppressed by receptor inverse agonists

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