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Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (27), p.10996-11001

2012

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Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase

PLoS neglected tropical diseases, 2016-08, Vol.10 (8), p.e0004791-e0004791

2016

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Functional analysis of drug resistance‐associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein

Molecular microbiology, 2015-05, Vol.96 (4), p.887-900

2015

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Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei

Frontiers in cellular and infection microbiology, 2023-07, Vol.13, p.1204707

2023

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Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA

Antimicrobial Agents and Chemotherapy, 2013-10, Vol.57 (10), p.4882-4893

2013

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Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages

PLoS neglected tropical diseases, 2020-07, Vol.14 (7), p.e0008447

2020

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Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms

PloS one, 2013-03, Vol.8 (3), p.e58034-e58034

2013

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Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

International journal for parasitology -- drugs and drug resistance, 2015-08, Vol.5 (2), p.65-68

2015

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The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes

Molecular pharmacology, 2011-07, Vol.80 (1), p.110-116

2011

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Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

International journal for parasitology -- drugs and drug resistance, 2019-04, Vol.9, p.35-43

2019

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Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

Journal of antimicrobial chemotherapy, 2014-03, Vol.69 (3), p.651-663

2014

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Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential

Molecular microbiology, 2021-08, Vol.116 (2), p.564-588

2021

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Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei

Frontiers in pharmacology, 2015-03, Vol.6, p.32-32

2015

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Comprehensive characterization of purine and pyrimidine transport activities in Trichomonas vaginalis and functional cloning of a trichomonad nucleoside transporter

Molecular microbiology, 2021-12, Vol.116 (6), p.1489-1511

2021

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Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy

Antimicrobial agents and chemotherapy, 2018-10, Vol.62 (10)

2018

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Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model

Journal of medicinal chemistry, 2019-03, Vol.62 (6), p.3021-3035

2019

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Trypanosoma brucei bloodstream forms express highly specific and separate transporters for adenine and hypoxanthine; evidence for a new protozoan purine transporter family?

Molecular and biochemical parasitology, 2018-03, Vol.220, p.46-56

2018

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Correction to “Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model”

Journal of medicinal chemistry, 2021-12, Vol.64 (24), p.18236-18236

2021

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Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi

Journal of antimicrobial chemotherapy, 2020-04, Vol.75 (4), p.958-967

2020

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Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Journal of medicinal chemistry, 2018-05, Vol.61 (9), p.3870-3888

2018

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Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense

Cellular and molecular life sciences : CMLS, 2016-09, Vol.73 (17), p.3387-3400

2016

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Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis

Future medicinal chemistry, 2019-07, Vol.11 (14), p.1703-1720

2019

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Oligopeptidase B deficient mutants of Leishmania major

Molecular and biochemical parasitology, 2011-01, Vol.175 (1), p.49-57

2011

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Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake

International journal for parasitology -- drugs and drug resistance, 2013-12, Vol.3, p.69-76

2013

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Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase

Functional analysis of drug resistance‐associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei

Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA

Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages

Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms

Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential

Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei

Comprehensive characterization of purine and pyrimidine transport activities in Trichomonas vaginalis and functional cloning of a trichomonad nucleoside transporter

Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy

Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model

Trypanosoma brucei bloodstream forms express highly specific and separate transporters for adenine and hypoxanthine; evidence for a new protozoan purine transporter family?

Correction to “Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model”

Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis

Oligopeptidase B deficient mutants of Leishmania major

Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake

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