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Virtual Screening of Combinatorial Libraries across a Gene Family: in Search of Inhibitors of Giardia lamblia Guanine Phosphoribosyltransferase

Antimicrobial Agents and Chemotherapy, 2001-09, Vol.45 (9), p.2571-2576

2001

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Rational Design of Selective Submicromolar Inhibitors of Tritrichomonas foetus Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase

Biochemistry (Easton), 2000-04, Vol.39 (16), p.4684-4691

2000

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Crystal Structures of Giardia lamblia Guanine Phosphoribosyltransferase at 1.75 Å

Biochemistry (Easton), 2000-06, Vol.39 (23), p.6781-6790

2000

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Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2218-2234

2013

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Steady-State Kinetics of the Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Tritrichomonas foetus: The Role of Threonine-47

Biochemistry (Easton), 1998-03, Vol.37 (12), p.4045-4051

1998

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Converting the Guanine Phosphoribosyltransferase from Giardia lamblia to a Hypoxanthine-guanine Phosphoribosyltransferase

The Journal of biological chemistry, 2000-11, Vol.275 (47), p.37072-37077

2000

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Rational Design of Novel Antimicrobials: Blocking Purine Salvage in a Parasitic Protozoan

Biochemistry (Easton), 1998-04, Vol.37 (16), p.5344-5348

1998

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Understanding Substrate Specificity in Human and Parasite Phosphoribosyltransferases through Calculation and Experiment

Biochemistry (Easton), 1999-08, Vol.38 (32), p.10298-10306

1999

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Altering the Purine Specifcity of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Tritrichomonas foetus by Structure-Based Point Mutations in the Enzyme Protein

Biochemistry (Easton), 1998-11, Vol.37 (47), p.16612-16619

1998

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Adenosine is the primary precursor of all purine nucleotides in Trichomonas vaginalis

Molecular and biochemical parasitology, 2003-04, Vol.127 (2), p.143-149

2003

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Identification of small molecule ceramide kinase inhibitors using a homogeneous chemiluminescence high throughput assay

Assay and drug development technologies, 2007-02, Vol.5 (1), p.65-74

2007

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The Purine Nucleoside Phosphorylase from Trichomonas vaginalis Is a Homologue of the Bacterial Enzyme

Biochemistry (Easton), 2002-08, Vol.41 (33), p.10382-10389

2002

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The pivotal role of guanine phosphoribosyltransferase in purine salvage by Giardia lamblia

Molecular microbiology, 2002-05, Vol.44 (4), p.1073-1079

2002

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Role of the Flexible Loop of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Tritrichomonas foetus in Enzyme Catalysis

Biochemistry (Easton), 2001-04, Vol.40 (14), p.4303-4311

2001

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Altering the purine specificity of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus by structure-based point mutations in the enzyme protein

Biochemistry (Easton), 1998-11, Vol.37 (47), p.16612

1998

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Point mutations in the guanine phosphoribosyltransferase from Giardia lamblia modulate pyrophosphate binding and enzyme catalysis

European journal of biochemistry, 1999-02, Vol.259 (3), p.565-571

1999

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Point mutations in the guanine phosphoribosyltransferase from Giardia lamblia modulate pyrophosphate binding and enzyme catalysis

European journal of biochemistry, 1999-02, Vol.259 (3), p.565-571

1999

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Virtual Screening of Combinatorial Libraries across a Gene Family: in Search of Inhibitors of Giardia lamblia Guanine Phosphoribosyltransferase

Rational Design of Selective Submicromolar Inhibitors of Tritrichomonas foetus Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase

Crystal Structures of Giardia lamblia Guanine Phosphoribosyltransferase at 1.75 Å

Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)

Steady-State Kinetics of the Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Tritrichomonas foetus: The Role of Threonine-47

Converting the Guanine Phosphoribosyltransferase from Giardia lamblia to a Hypoxanthine-guanine Phosphoribosyltransferase

Rational Design of Novel Antimicrobials: Blocking Purine Salvage in a Parasitic Protozoan

Understanding Substrate Specificity in Human and Parasite Phosphoribosyltransferases through Calculation and Experiment

Altering the Purine Specifcity of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Tritrichomonas foetus by Structure-Based Point Mutations in the Enzyme Protein

Adenosine is the primary precursor of all purine nucleotides in Trichomonas vaginalis

Identification of small molecule ceramide kinase inhibitors using a homogeneous chemiluminescence high throughput assay

The Purine Nucleoside Phosphorylase from Trichomonas vaginalis Is a Homologue of the Bacterial Enzyme

The pivotal role of guanine phosphoribosyltransferase in purine salvage by Giardia lamblia

Role of the Flexible Loop of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Tritrichomonas foetus in Enzyme Catalysis

Altering the purine specificity of hypoxanthine-guanine-xanthine phosphoribosyltransferase from Tritrichomonas foetus by structure-based point mutations in the enzyme protein

Point mutations in the guanine phosphoribosyltransferase from Giardia lamblia modulate pyrophosphate binding and enzyme catalysis

Point mutations in the guanine phosphoribosyltransferase from Giardia lamblia modulate pyrophosphate binding and enzyme catalysis

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