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IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

Cancer cell, 2011-12, Vol.20 (6), p.781-796

2011

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IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without De Novo Infiltration from Secondary Lymphoid Organs

Cancer research (Chicago, Ill.), 2012-07, Vol.72 (14), p.3570-3581

2012

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Pegylated IL-10 induces cancer immunity

BioEssays, 2013-07, Vol.35 (7), p.623-631

2013

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IL-33 Induces IL-13-Dependent Cutaneous Fibrosis

The Journal of immunology (1950), 2010-02, Vol.184 (3), p.1526-1535

2010

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Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors

Journal of clinical oncology, 2016-10, Vol.34 (29), p.3562-3569

2016

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IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression

The Journal of immunology (1950), 2017-11, Vol.199 (9), p.3316-3325

2017

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PEGylated IL-10 Activates Kupffer Cells to Control Hypercholesterolemia

PloS one, 2016-06, Vol.11 (6), p.e0156229

2016

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The Protein Product of the Tumor Suppressor Gene, Melanoma Differentiation-Associated Gene 7, Exhibits Immunostimulatory Activity and Is Designated IL-24

The Journal of immunology (1950), 2002-06, Vol.168 (12), p.6041-6046

2002

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755 DEKA-1 a dose-finding Phase 1 trial: observing safety and biomarkers using DK210 (EGFR) for inoperable locally advanced and/or metastatic EGFR+ tumors failing systemic therapy

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A851-A851

2023

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Pegylated IL-10 induces cancer immunity: the surprising role of IL-10 as a potent inducer of IFN-γ-mediated CD8(+) T cell cytotoxicity

BioEssays, 2013-07, Vol.35 (7), p.623-631

2013

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Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor

Cancer research (Chicago, Ill.), 2003-08, Vol.63 (16), p.5105-5113

2003

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PEG-rIL-10 treatment decreases FoxP3+ Tregs despite upregulation of intratumoral IDO

Oncoimmunology, 2016-07, Vol.5 (7), p.e1197458-e1197458

2016

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Subversion and coercion: the art of redirecting tumor immune surveillance

Current topics in microbiology and immunology, 2011-01, Vol.344, p.25

2011

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Bystander Activity of Ad-mda7: Human MDA-7 Protein Kills Melanoma Cells via an IL-20 Receptor-Dependent but STAT3-Independent Mechanism

Molecular therapy, 2004-12, Vol.10 (6), p.1085-1095

2004

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Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8+ T cells

Oncoimmunology, 2012-12, Vol.1 (9), p.1637-1639

2012

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Quantitative Analysis of Hepatitis C Virus-Specific CD8+ T Cells in Peripheral Blood and Liver Using Peptide-MHC Tetramers

Proceedings of the National Academy of Sciences - PNAS, 1999-05, Vol.96 (10), p.5692-5697

1999

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Killing of human melanoma cells induced by activation of class I interferon-regulated signaling pathways via MDA-7/IL-24

Cytokine (Philadelphia, Pa.), 2008-07, Vol.43 (1), p.34-44

2008

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MDA-7/IL-24 is a unique cytokine–tumor suppressor in the IL-10 Family

International immunopharmacology, 2004-05, Vol.4 (5), p.649-667

2004

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Killing from within

Oncoimmunology, 2012-12, Vol.1 (9), p.1598-1600

2012

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mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: Identification of IL-20 receptor-mediated bystander activity against pancreatic cancer

Molecular therapy, 2005-05, Vol.11 (5), p.724-733

2005

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Abstract 4720: TIGIT blockade enhances cytolytic function in antigen-specific CTLs in a manner non-redundant to PD1 blockade

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.4720-4720

2018

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IL-10: Expanding the Immune Oncology Horizon

Receptors & clinical investigation, 2015-01, Vol.2 (4)

2015

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Soluble human MDA-7/IL-24: characterization of the molecular form(s) inhibiting tumor growth and stimulating monocytes

Journal of interferon & cytokine research, 2006-12, Vol.26 (12), p.877

2006

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Negative association of melanoma differentiation-associated gene (mda-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells

Molecular cancer therapeutics, 2003-01, Vol.2 (1), p.9-17

2003

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IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance

IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without De Novo Infiltration from Secondary Lymphoid Organs

Pegylated IL-10 induces cancer immunity

PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients

IL-33 Induces IL-13-Dependent Cutaneous Fibrosis

Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors

IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression

PEGylated IL-10 Activates Kupffer Cells to Control Hypercholesterolemia

The Protein Product of the Tumor Suppressor Gene, Melanoma Differentiation-Associated Gene 7, Exhibits Immunostimulatory Activity and Is Designated IL-24

755 DEKA-1 a dose-finding Phase 1 trial: observing safety and biomarkers using DK210 (EGFR) for inoperable locally advanced and/or metastatic EGFR+ tumors failing systemic therapy

Pegylated IL-10 induces cancer immunity: the surprising role of IL-10 as a potent inducer of IFN-γ-mediated CD8(+) T cell cytotoxicity

Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor

PEG-rIL-10 treatment decreases FoxP3+ Tregs despite upregulation of intratumoral IDO

Subversion and coercion: the art of redirecting tumor immune surveillance

Bystander Activity of Ad-mda7: Human MDA-7 Protein Kills Melanoma Cells via an IL-20 Receptor-Dependent but STAT3-Independent Mechanism

Autochthonous T cells to the rescue: IL-10 directly activates tumor-resident CD8+ T cells

Quantitative Analysis of Hepatitis C Virus-Specific CD8+ T Cells in Peripheral Blood and Liver Using Peptide-MHC Tetramers

Killing of human melanoma cells induced by activation of class I interferon-regulated signaling pathways via MDA-7/IL-24

MDA-7/IL-24 is a unique cytokine–tumor suppressor in the IL-10 Family

Killing from within

mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: Identification of IL-20 receptor-mediated bystander activity against pancreatic cancer

Abstract 4720: TIGIT blockade enhances cytolytic function in antigen-specific CTLs in a manner non-redundant to PD1 blockade

IL-10: Expanding the Immune Oncology Horizon

Soluble human MDA-7/IL-24: characterization of the molecular form(s) inhibiting tumor growth and stimulating monocytes

Negative association of melanoma differentiation-associated gene (mda-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells

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