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SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

Nature communications, 2021-03, Vol.12 (1), p.1876-1876, Article 1876

2021

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The interplay between cell signalling and the mevalonate pathway in cancer

Nature reviews. Cancer, 2016-11, Vol.16 (11), p.718-731

2016

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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

Cell metabolism, 2021-05, Vol.33 (5), p.1013-1026.e6

2021

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The aging tumor metabolic microenvironment

Current opinion in biotechnology, 2023-12, Vol.84, p.102995-102995, Article 102995

2023

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MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Cancer research (Chicago, Ill.), 2013-11, Vol.73 (21), p.6504-6515

2013

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Methionine restriction forces Epstein-Barr virus out of latency

Cell metabolism, 2022-09, Vol.34 (9), p.1229-1231

2022

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Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

Cell, 2018-09, Vol.175 (1), p.117-132.e21

2018

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MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

Cancer cell, 2018-10, Vol.34 (4), p.579-595.e8

2018

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AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Blood, 2015-03, Vol.125 (13), p.2120-2130

2015

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Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins

Cancer research (Chicago, Ill.), 2018-03, Vol.78 (5), p.1347-1357

2018

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Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

Biochimica et biophysica acta, 2011-12, Vol.1813 (12), p.2079-2087

2011

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Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop

Cancer research (Chicago, Ill.), 2014-09, Vol.74 (17), p.4772-4782

2014

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The Metabolic Relationship Between Viral Infection and Cancer

Annual review of cancer biology, 2022-04, Vol.6 (1), p.1-15

2022

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A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer

Prostate cancer and prostatic diseases, 2020-12, Vol.23 (4), p.630-637

2020

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Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo

Archives of toxicology, 2016-01, Vol.90 (1), p.203-215

2016

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Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

Oncotarget, 2015-09, Vol.6 (29), p.26909-26921

2015

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Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells

Breast cancer research and treatment, 2014, Vol.143 (2), p.301-312

2014

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Largen: A Molecular Regulator of Mammalian Cell Size Control

Molecular cell, 2014-03, Vol.53 (6), p.904-915

2014

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Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans

Therapeutic drug monitoring, 2012-08, Vol.34 (4), p.406-414

2012

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Abstract 3543: Targeting the metabolic mevalonate pathway with statins as anti-breast cancer agents

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.3543-3543

2017

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Abstract C165: Breast cancer, statins, and 3-D cell culture

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.C165-C165

2011

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Identifying molecular features that distinguish fluvastatinsensitive breast tumor cells

Breast cancer research and treatment, 2014-01, Vol.143 (2), p.301

2014

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Gastrointestinal endoscopy in the young

BMJ, 1987-09, Vol.295 (6600), p.724-724

1987

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TENET 2.0: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma

PLoS genetics, 2020-09, Vol.16 (9), p.e1009023

2020

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SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

The interplay between cell signalling and the mevalonate pathway in cancer

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

The aging tumor metabolic microenvironment

MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity

Methionine restriction forces Epstein-Barr virus out of latency

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins

Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop

The Metabolic Relationship Between Viral Infection and Cancer

A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer

Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells

Largen: A Molecular Regulator of Mammalian Cell Size Control

Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans

Abstract 3543: Targeting the metabolic mevalonate pathway with statins as anti-breast cancer agents

Abstract C165: Breast cancer, statins, and 3-D cell culture

Identifying molecular features that distinguish fluvastatinsensitive breast tumor cells

Gastrointestinal endoscopy in the young

TENET 2.0: Identification of key transcriptional regulators and enhancers in lung adenocarcinoma

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