UB Paderborn / Katalog / Suche / in CDI

Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human

Human vaccines & immunotherapeutics, 2019-06, Vol.15 (6), p.1338-1356

2019

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Toward a Multivalent Synthetic Oligosaccharide-Based Conjugate Vaccine against Shigella : State-of-the-Art for a Monovalent Prototype and Challenges

Vaccines (Basel), 2022-03, Vol.10 (3), p.403

2022

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Bacteriophage Sf6 Tailspike Protein for Detection of Shigella flexneri Pathogens

Viruses, 2018-08, Vol.10 (8), p.431

2018

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Further characterization of Shigella -specific (memory) B cells induced in healthy volunteer recipients of SF2a-TT15, a Shigella flexneri 2a synthetic glycan-based vaccine candidate

Frontiers in immunology, 2023-10, Vol.14, p.1291664-1291664

2023

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Computer-aided engineering of a branching sucrase for the glucodiversification of a tetrasaccharide precursor of S. flexneri antigenic oligosaccharides

Scientific reports, 2021-10, Vol.11 (1), p.20294-20294, Article 20294

2021

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Redirecting substrate regioselectivity using engineered ΔN123-GBD-CD2 branching sucrases for the production of pentasaccharide repeating units of S. flexneri 3a, 4a and 4b haptens

Scientific reports, 2021-01, Vol.11 (1), p.2474-2474, Article 2474

2021

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Exploratory N‐Protecting Group Manipulation for the Total Synthesis of Zwitterionic Shigella sonnei Oligosaccharides

Chemistry : a European journal, 2021-03, Vol.27 (18), p.5694-5711

2021

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Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxidation

Tetrahedron, 2013-12, Vol.69 (48), p.10337-10350

2013

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Scalable Synthesis of Versatile Rare Deoxyamino Sugar Building Blocks from d‑Glucosamine

Journal of organic chemistry, 2023-06, Vol.88 (11), p.6645-6663

2023

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Computer-Aided Engineering of a Transglycosylase for the Glucosylation of an Unnatural Disaccharide of Relevance for Bacterial Antigen Synthesis

ACS catalysis, 2015-02, Vol.5 (2), p.1186-1198

2015

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On the Preparation of Carbohydrate−Protein Conjugates Using the Traceless Staudinger Ligation

Journal of organic chemistry, 2005-09, Vol.70 (18), p.7123-7132

2005

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A Shigella flexneri 2a synthetic glycan-based vaccine induces a long-lasting immune response in adults

npj vaccines, 2023-03, Vol.8 (1), p.35-35, Article 35

2023

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Expedient synthesis of l-heptose derived septacidin building blocks from l-glucose

Carbohydrate research, 2023-12, Vol.534, p.108985-108985, Article 108985

2023

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Protecting group principles suited to late stage functionalization and global deprotection in oligosaccharide synthesis

Carbohydrate research, 2022-11, Vol.521, p.108644-108644, Article 108644

2022

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Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study

The Lancet infectious diseases, 2021-04, Vol.21 (4), p.546-558

2021

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Synthesis of branched tri- to pentasaccharides representative of fragments of Shigella flexneri serotypes 3a and/or X O-antigens

Tetrahedron, 2008-11, Vol.64 (46), p.10558-10572

2008

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Structural Studies of the O-Acetyl-Containing O-Antigen from a Shigella flexneri Serotype 6 Strain and Synthesis of Oligosaccharide Fragments Thereof

European journal of organic chemistry, 2013-07, Vol.2013 (19), p.4085-4106

2013

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ADP‐heptose is a newly identified pathogen‐associated molecular pattern of Shigella flexneri

EMBO reports, 2018-12, Vol.19 (12), p.n/a

2018

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Combination of High-Resolution Multistage Ion Mobility and Tandem MS with High Energy of Activation to Resolve the Structure of Complex Chemoenzymatically Synthesized Glycans

Analytical chemistry (Washington), 2022-02, Vol.94 (4), p.2279-2287

2022

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Multigram synthesis of an orthogonally-protected pentasaccharide for use as a glycan precursor in a Shigella flexneri 3a conjugate vaccine: application to a ready-for-conjugation decasaccharide

Organic chemistry frontiers an international journal of organic chemistry, 2021-11, Vol.8 (22), p.6279-6299

2021

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A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity

Bioconjugate chemistry, 2016-04, Vol.27 (4), p.883-892

2016

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Convergent Chemoenzymatic Strategy to Deliver a Diversity of Shigella flexneri Serotype-Specific O‑Antigen Segments from a Unique Lightly Protected Tetrasaccharide Core

Journal of organic chemistry, 2021-02, Vol.86 (3), p.2058-2075

2021

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Efficient Iterative Synthesis of O-Acetylated Tri- to Pentadecasaccharides Related to the Lipopolysaccharide of Shigella flexneri Type 3a through Di- and Trisaccharide Glycosyl Donors

Chemistry, an Asian journal, 2017-02, Vol.12 (4), p.419

2017

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Efficient Iterative Synthesis of O‐Acetylated Tri‐ to Pentadecasaccharides Related to the Lipopolysaccharide of Shigella flexneri Type 3 a through Di‐ and Trisaccharide Glycosyl Donors

Chemistry, an Asian journal, 2017-02, Vol.12 (4), p.419-439

2017

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Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri 3a

Chemistry : a European journal, 2016-07, Vol.22 (31), p.10892-10911

2016

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Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human

Toward a Multivalent Synthetic Oligosaccharide-Based Conjugate Vaccine against Shigella : State-of-the-Art for a Monovalent Prototype and Challenges

Bacteriophage Sf6 Tailspike Protein for Detection of Shigella flexneri Pathogens

Further characterization of Shigella -specific (memory) B cells induced in healthy volunteer recipients of SF2a-TT15, a Shigella flexneri 2a synthetic glycan-based vaccine candidate

Computer-aided engineering of a branching sucrase for the glucodiversification of a tetrasaccharide precursor of S. flexneri antigenic oligosaccharides

Redirecting substrate regioselectivity using engineered ΔN123-GBD-CD2 branching sucrases for the production of pentasaccharide repeating units of S. flexneri 3a, 4a and 4b haptens

Exploratory N‐Protecting Group Manipulation for the Total Synthesis of Zwitterionic Shigella sonnei Oligosaccharides

Concise synthesis of di- and trisaccharides related to the O-antigens from Shigella flexneri serotypes 6 and 6a, based on late stage mono-O-acetylation and/or site-selective oxidation

Scalable Synthesis of Versatile Rare Deoxyamino Sugar Building Blocks from d‑Glucosamine

Computer-Aided Engineering of a Transglycosylase for the Glucosylation of an Unnatural Disaccharide of Relevance for Bacterial Antigen Synthesis

On the Preparation of Carbohydrate−Protein Conjugates Using the Traceless Staudinger Ligation

A Shigella flexneri 2a synthetic glycan-based vaccine induces a long-lasting immune response in adults

Expedient synthesis of l-heptose derived septacidin building blocks from l-glucose

Protecting group principles suited to late stage functionalization and global deprotection in oligosaccharide synthesis

Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study

Synthesis of branched tri- to pentasaccharides representative of fragments of Shigella flexneri serotypes 3a and/or X O-antigens

Structural Studies of the O-Acetyl-Containing O-Antigen from a Shigella flexneri Serotype 6 Strain and Synthesis of Oligosaccharide Fragments Thereof

ADP‐heptose is a newly identified pathogen‐associated molecular pattern of Shigella flexneri

Combination of High-Resolution Multistage Ion Mobility and Tandem MS with High Energy of Activation to Resolve the Structure of Complex Chemoenzymatically Synthesized Glycans

Multigram synthesis of an orthogonally-protected pentasaccharide for use as a glycan precursor in a Shigella flexneri 3a conjugate vaccine: application to a ready-for-conjugation decasaccharide

A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity

Convergent Chemoenzymatic Strategy to Deliver a Diversity of Shigella flexneri Serotype-Specific O‑Antigen Segments from a Unique Lightly Protected Tetrasaccharide Core

Efficient Iterative Synthesis of O-Acetylated Tri- to Pentadecasaccharides Related to the Lipopolysaccharide of Shigella flexneri Type 3a through Di- and Trisaccharide Glycosyl Donors

Efficient Iterative Synthesis of O‐Acetylated Tri‐ to Pentadecasaccharides Related to the Lipopolysaccharide of Shigella flexneri Type 3 a through Di‐ and Trisaccharide Glycosyl Donors

Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri 3a

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