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Natural products: promising resources for cancer drug discovery

Anti-cancer agents in medicinal chemistry, 2012-01, Vol.12 (1), p.49

2012

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Role of oxidation‐triggered activation of JNK and p38 MAPK in black tea polyphenols induced apoptotic death of A375 cells

Cancer science, 2009-10, Vol.100 (10), p.1971-1978

2009

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Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I

Biochemical journal, 2002-09, Vol.366 (Pt 2), p.653-661

2002

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Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms

Journal of antimicrobial chemotherapy, 1999-12, Vol.44 (6), p.791-794

1999

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Withaferin A modulates the Spindle Assembly Checkpoint by degradation of Mad2–Cdc20 complex in colorectal cancer cell lines

Biochemical pharmacology, 2014-09, Vol.91 (1), p.31-39

2014

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One-pot synthesis of the naturally occurring dimeric carbazole alkaloid murranimbine and its analogue

Tetrahedron letters, 2010-07, Vol.51 (29), p.3732-3735

2010

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Comparative Antimutagenic and Anticancer Activity of Three Fractions of Black Tea Polyphenols Thearubigins

Nutrition and cancer, 2011-10, Vol.63 (7), p.1122-1132

2011

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Phytochemical investigations and evaluation of antimutagenic activity of the alcoholic extract of Glycosmis pentaphylla and Tabernaemontana coronaria by Ames test

Natural product research, 2018-03, Vol.32 (5), p.582-587

2018

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Voacamine alters Leishmania ultrastructure and kills parasite by poisoning unusual bi-subunit topoisomerase IB

Biochemical pharmacology, 2017-08, Vol.138, p.19-30

2017

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14-Deoxyandrographolide alleviates ethanol-induced hepatosteatosis through stimulation of AMP-activated protein kinase activity in rats

Alcohol (Fayetteville, N.Y.), 2014-03, Vol.48 (2), p.123-132

2014

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Novel betulin derivatives as antileishmanial agents with mode of action targeting type IB DNA topoisomerase

Molecular pharmacology, 2011-10, Vol.80 (4), p.694-703

2011

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Angustinine – A New Benzopyridoquinolizine Alkaloid from Alangium lamarckii

Natural product communications, 2012-09, Vol.7 (9), p.1169-1170

2012

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Disuccinyl Betulin Triggers Metacaspase-Dependent Endonuclease G-Mediated Cell Death in Unicellular Protozoan Parasite Leishmania donovani

Antimicrobial agents and chemotherapy, 2014-04, Vol.58 (4), p.2186-2201

2014

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Quercetin interferes with iron metabolism in Leishmania donovani and targets ribonucleotide reductase to exert leishmanicidal activity

Journal of antimicrobial chemotherapy, 2008-05, Vol.61 (5), p.1066-1075

2008

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The lignan glycosides lyoniside and saracoside poison the unusual type IB topoisomerase of Leishmania donovani and kill the parasite both in vitro and in vivo

Biochemical pharmacology, 2013-12, Vol.86 (12), p.1673-1687

2013

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14-Deoxyandrographolide targets adenylate cyclase and prevents ethanol-induced liver injury through constitutive NOS dependent reduced redox signaling in rats

Food and chemical toxicology, 2013-09, Vol.59, p.236-248

2013

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Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade

Carcinogenesis (New York), 2008-01, Vol.29 (1), p.129-138

2008

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Anthocephaline, a New Indole Alkaloid and Cadambine, a Potent Inhibitor of DNA Topoisomerase IB of Leishmania donovani (LdTOP1LS), Isolated from Anthocephalus cadamba

Natural product communications, 2015-02, Vol.10 (2), p.297-299

2015

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Anticlastogenic effects of black tea polyphenols theaflavins and thearubigins in human lymphocytes in vitro

Toxicology (Amsterdam), 2006-08, Vol.20 (5), p.608-613

2006

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Withanolide Z, a new chlorinated withanolide from Withania somnifera

Planta medica, 2008-11, Vol.74 (14), p.1745

2008

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Saracoside: A New Lignan Glycoside from Saraca indica, a Potential Inhibitor of DNA Topoisomerase IB

Natural product communications, 2012-06, Vol.7 (6), p.767-769

2012

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Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis

Molecular medicine (Cambridge, Mass.), 2000-06, Vol.6 (6), p.527-541

2000

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A New Ellagic Acid Glycoside and DNA Topoisomerase IB Inhibitory Activity of Saponins from Putranjiva roxburghii

Natural product communications, 2014-05, Vol.9 (5), p.675-677

2014

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Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis

Free radical biology & medicine, 2005-05, Vol.38 (9), p.1257-1264

2005

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Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives

Medical science monitor, 2002-07, Vol.8 (7), p.BR254-BR265

2002

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Natural products: promising resources for cancer drug discovery

Role of oxidation‐triggered activation of JNK and p38 MAPK in black tea polyphenols induced apoptotic death of A375 cells

Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I

Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms

Withaferin A modulates the Spindle Assembly Checkpoint by degradation of Mad2–Cdc20 complex in colorectal cancer cell lines

One-pot synthesis of the naturally occurring dimeric carbazole alkaloid murranimbine and its analogue

Comparative Antimutagenic and Anticancer Activity of Three Fractions of Black Tea Polyphenols Thearubigins

Phytochemical investigations and evaluation of antimutagenic activity of the alcoholic extract of Glycosmis pentaphylla and Tabernaemontana coronaria by Ames test

Voacamine alters Leishmania ultrastructure and kills parasite by poisoning unusual bi-subunit topoisomerase IB

14-Deoxyandrographolide alleviates ethanol-induced hepatosteatosis through stimulation of AMP-activated protein kinase activity in rats

Novel betulin derivatives as antileishmanial agents with mode of action targeting type IB DNA topoisomerase

Angustinine – A New Benzopyridoquinolizine Alkaloid from Alangium lamarckii

Disuccinyl Betulin Triggers Metacaspase-Dependent Endonuclease G-Mediated Cell Death in Unicellular Protozoan Parasite Leishmania donovani

Quercetin interferes with iron metabolism in Leishmania donovani and targets ribonucleotide reductase to exert leishmanicidal activity

The lignan glycosides lyoniside and saracoside poison the unusual type IB topoisomerase of Leishmania donovani and kill the parasite both in vitro and in vivo

14-Deoxyandrographolide targets adenylate cyclase and prevents ethanol-induced liver injury through constitutive NOS dependent reduced redox signaling in rats

Molecular mechanism of black tea polyphenols induced apoptosis in human skin cancer cells: involvement of Bax translocation and mitochondria mediated death cascade

Anthocephaline, a New Indole Alkaloid and Cadambine, a Potent Inhibitor of DNA Topoisomerase IB of Leishmania donovani (LdTOP1LS), Isolated from Anthocephalus cadamba

Anticlastogenic effects of black tea polyphenols theaflavins and thearubigins in human lymphocytes in vitro

Withanolide Z, a new chlorinated withanolide from Withania somnifera

Saracoside: A New Lignan Glycoside from Saraca indica, a Potential Inhibitor of DNA Topoisomerase IB

Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis

A New Ellagic Acid Glycoside and DNA Topoisomerase IB Inhibitory Activity of Saponins from Putranjiva roxburghii

Therapeutic use of quercetin in the control of infection and anemia associated with visceral leishmaniasis

Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives

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