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mRNA-based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus-neutralising antibodies and mediates protection in rodents

npj vaccines, 2021-04, Vol.6 (1), p.57-9, Article 57

2021

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CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

Nature communications, 2021-06, Vol.12 (1), p.4048-4048, Article 4048

2021

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Efficacy of an unmodified bivalent mRNA vaccine against SARS-CoV-2 variants in female small animal models

Nature communications, 2023-02, Vol.14 (1), p.816-816, Article 816

2023

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A Low-Toxicity IL-2―Based Immunocytokine Retains Antitumor Activity Despite Its High Degree of IL-2 Receptor Selectivity

Clinical cancer research, 2011-06, Vol.17 (11), p.3673-3685

2011

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A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses

Molecular therapy. Methods & clinical development, 2022-12, Vol.27, p.309-323

2022

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Optimised Non-Coding Regions of mRNA SARS-CoV-2 Vaccine CV2CoV Improves Homologous and Heterologous Neutralising Antibody Responses

Vaccines (Basel), 2022-08, Vol.10 (8), p.1251

2022

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mRNA vaccines induce rapid antibody responses in mice

npj vaccines, 2022-08, Vol.7 (1), p.88-88, Article 88

2022

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Safety and immunogenicity of a modified mRNA-lipid nanoparticle vaccine candidate against COVID-19: Results from a phase 1, dose-escalation study

Human vaccines & immunotherapeutics, 2024-12, Vol.20 (1), p.2408863

2024

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Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: A valuable model for in vitro toxicity and drug–drug interaction studies

Chemico-biological interactions, 2009-09, Vol.181 (1), p.124-137

2009

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Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project

Toxicology in vitro, 2015-12, Vol.30 (1), p.19-26

2015

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Overview of in vitro tools to assess the estrogenic and antiestrogenic activity of phytoestrogens

Journal of Chromatography B, 2002-09, Vol.777 (1), p.155-165

Mueller, Stefan O

2002

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Development of stably transfected human and rat hepatoma cell lines for the species-specific assessment of xenobiotic response enhancer module (XREM)-dependent induction of drug metabolism

Toxicology (Amsterdam), 2010-11, Vol.277 (1), p.11-19

2010

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Assessment of Immunogenicity and Efficacy of CV0501 mRNA-Based Omicron COVID-19 Vaccination in Small Animal Models

Vaccines (Basel), 2023-01, Vol.11 (2), p.318

2023

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Activation of P53 in HepG2 cells as surrogate to detect mutagens and promutagens in vitro

Toxicology letters, 2010-10, Vol.198 (2), p.272-281

2010

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Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure

Toxicology in vitro, 2015-12, Vol.30 (1), p.52-61

2015

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Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β–induced apoptosis

Hepatology (Baltimore, Md.), 2009-06, Vol.49 (6), p.2031-2043

2009

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Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2: A phase 1 randomized clinical trial

Wiener Klinische Wochenschrift, 2021-09, Vol.133 (17-18), p.931-941

2021

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IABS/CEPI platform technology webinar: Is it possible to reduce the vaccine development time?

Biologicals, 2021-06, Vol.71, p.55-60

2021

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Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes

Chemico-biological interactions, 2009-04, Vol.179 (1), p.17-24

2009

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Species differences in the response of liver drug-metabolizing enzymes to (S)-4-O-tolylsulfanyl-2-(4-trifluormethyl-phenoxy)-butyric acid (EMD 392949) in vivo and in vitro

Drug metabolism and disposition, 2008-04, Vol.36 (4), p.702-714

2008

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Effects of cell culture conditions on primary rat hepatocytes—Cell morphology and differential gene expression

Toxicology (Amsterdam), 2006-02, Vol.218 (2), p.205-215

2006

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Xenoestrogens: mechanisms of action and detection methods

Analytical and bioanalytical chemistry, 2004-02, Vol.378 (3), p.582-587

Mueller, Stefan O

2004

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Development of a New Screening Assay to Identify Proteratogenic Substances using Zebrafish Danio rerio Embryo Combined with an Exogenous Mammalian Metabolic Activation System (mDarT)

Toxicological sciences, 2008-07, Vol.104 (1), p.177-188

2008

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mRNA-based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus-neutralising antibodies and mediates protection in rodents

CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

Efficacy of an unmodified bivalent mRNA vaccine against SARS-CoV-2 variants in female small animal models

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

A Low-Toxicity IL-2―Based Immunocytokine Retains Antitumor Activity Despite Its High Degree of IL-2 Receptor Selectivity

A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses

Optimised Non-Coding Regions of mRNA SARS-CoV-2 Vaccine CV2CoV Improves Homologous and Heterologous Neutralising Antibody Responses

mRNA vaccines induce rapid antibody responses in mice

Safety and immunogenicity of a modified mRNA-lipid nanoparticle vaccine candidate against COVID-19: Results from a phase 1, dose-escalation study

Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: A valuable model for in vitro toxicity and drug–drug interaction studies

Drug biokinetic and toxicity assessments in rat and human primary hepatocytes and HepaRG cells within the EU-funded Predict-IV project

Overview of in vitro tools to assess the estrogenic and antiestrogenic activity of phytoestrogens

Development of stably transfected human and rat hepatoma cell lines for the species-specific assessment of xenobiotic response enhancer module (XREM)-dependent induction of drug metabolism

Assessment of Immunogenicity and Efficacy of CV0501 mRNA-Based Omicron COVID-19 Vaccination in Small Animal Models

Activation of P53 in HepG2 cells as surrogate to detect mutagens and promutagens in vitro

Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine

Biokinetics of chlorpromazine in primary rat and human hepatocytes and human HepaRG cells after repeated exposure

Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor β–induced apoptosis

Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2: A phase 1 randomized clinical trial

IABS/CEPI platform technology webinar: Is it possible to reduce the vaccine development time?

Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes

Species differences in the response of liver drug-metabolizing enzymes to (S)-4-O-tolylsulfanyl-2-(4-trifluormethyl-phenoxy)-butyric acid (EMD 392949) in vivo and in vitro

Effects of cell culture conditions on primary rat hepatocytes—Cell morphology and differential gene expression

Xenoestrogens: mechanisms of action and detection methods

Development of a New Screening Assay to Identify Proteratogenic Substances using Zebrafish Danio rerio Embryo Combined with an Exogenous Mammalian Metabolic Activation System (mDarT)

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