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PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding

ACS chemical biology, 2019-03, Vol.14 (3), p.342-347

2019

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Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors

ACS chemical biology, 2017-10, Vol.12 (10), p.2515-2521

2017

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Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

ACS medicinal chemistry letters, 2019-05, Vol.10 (5), p.780-785

2019

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A caged E3 ligase ligand for PROTAC-mediated protein degradation with light

Chemical communications (Cambridge, England), 2020-05, Vol.56 (41), p.5532-5535

2020

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Drug selectivity: Running in the family

Nature chemical biology, 2014-08, Vol.10 (8), p.608

2014

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Design of amidobenzimidazole STING receptor agonists with systemic activity

Nature (London), 2018-12, Vol.564 (7736), p.439-443

2018

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Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

Nature chemical biology, 2016-11, Vol.12 (11), p.908

2016

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Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP

Journal of the American Chemical Society, 2019-02, Vol.141 (6), p.2703-2712

2019

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Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells

Scientific reports, 2019-10, Vol.9 (1), p.14159-14, Article 14159

2019

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A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level

ACS chemical biology, 2016-09, Vol.11 (9), p.2541-2550

2016

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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Angewandte Chemie International Edition, 2021-10, Vol.60 (43), p.23327-23334

International ed. in English, 2021

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amTCO, a new trans-cyclooctene derivative to study drug-target interactions in cells

Chemical communications (Cambridge, England), 2021-02, Vol.57 (14), p.1814-1817

2021

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Characterization of Apo‐Form Selective Inhibition of Indoleamine 2,3‐Dioxygenase

Chembiochem : a European journal of chemical biology, 2021-02, Vol.22 (3), p.516-522

2021

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Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency

Drug resistance updates, 2023-03, Vol.67, p.100932-100932, Article 100932

2023

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Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5455-5471

2017

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Interrogating the Druggability of the 2‑Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics

ACS chemical biology, 2016-07, Vol.11 (7), p.2002-2010

2016

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Abstract P4-08-09: Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2-deficiency

Cancer research (Chicago, Ill.), 2023-03, Vol.83 (5_Supplement), p.P4-P4-08-09

2023

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Toluidinesulfonamide Hypoxia-Induced Factor 1 Inhibitors: Alleviating Drug–Drug Interactions through Use of PubChem Data and Comparative Molecular Field Analysis Guided Synthesis

Journal of medicinal chemistry, 2011-06, Vol.54 (11), p.3982-3986

2011

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Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity

Nature (London), 2019-06, Vol.570 (7761), p.E53-E53

2019

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A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications

SLAS discovery, 2021-08, Vol.26 (7), p.885-895

2021

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Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

Angewandte Chemie, 2021-10, Vol.133 (43), p.23515-23522

2021

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ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma

PloS one, 2012-01, Vol.7 (1), p.e31120

2012

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ChemInform Abstract: The Synthesis and Oxidative Properties of Polymer-Supported IBX

ChemInform, 2002-05, Vol.33 (18), p.no-no

2002

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PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding

Differential Kinobeads Profiling for Target Identification of Irreversible Kinase Inhibitors

Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor

A caged E3 ligase ligand for PROTAC-mediated protein degradation with light

Drug selectivity: Running in the family

Design of amidobenzimidazole STING receptor agonists with systemic activity

Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP

Chemical proteomics reveals target selectivity of clinical Jak inhibitors in human primary cells

A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level

Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

amTCO, a new trans-cyclooctene derivative to study drug-target interactions in cells

Characterization of Apo‐Form Selective Inhibition of Indoleamine 2,3‐Dioxygenase

Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency

Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3‑Amino-4-pyridine Carboxylate Derivatives

Interrogating the Druggability of the 2‑Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics

Abstract P4-08-09: Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2-deficiency

Toluidinesulfonamide Hypoxia-Induced Factor 1 Inhibitors: Alleviating Drug–Drug Interactions through Use of PubChem Data and Comparative Molecular Field Analysis Guided Synthesis

Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity

A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications

Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs

ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma

ChemInform Abstract: The Synthesis and Oxidative Properties of Polymer-Supported IBX

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