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In silico, in vitro and in situ models to assess interplay between CYP3A and P-gp

Current drug metabolism, 2011-10, Vol.12 (8), p.750

2011

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Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design

ACS medicinal chemistry letters, 2016-09, Vol.7 (9), p.857-861

2016

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Development of LC-MS/MS-Based Receptor Occupancy Tracers and Positron Emission Tomography Radioligands for the Nociceptin/Orphanin FQ (NOP) Receptor

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.4955-4967

2012

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Absorption Barriers in the Rat Intestinal Mucosa: 1. Application of an In Situ Perfusion Model to Simultaneously Assess Drug Permeation and Metabolism

Journal of pharmaceutical sciences, 2010-02, Vol.99 (2), p.982-998

2010

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Translating Molecules into Medicines: Cross-Functional Integration at the Drug Discovery-Development Interface

1, 2017

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The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

Toxicology and Applied Pharmacology, 2004-09, Vol.199 (3), p.193-209

2004

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Absorption Barriers in the Rat Intestinal Mucosa. 3: Effects of Polyethoxylated Solubilizing Agents on Drug Permeation and Metabolism

Journal of pharmaceutical sciences, 2010-02, Vol.99 (2), p.1016-1027

2010

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A Highly Selective Hydantoin Inhibitor of Aggrecanase‑1 and Aggrecanase‑2 with a Low Projected Human Dose

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5933-5939

2017

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Discovery of a Novel Series of Orally Active Nociceptin/Orphanin FQ (NOP) Receptor Antagonists Based on a Dihydrospiro(piperidine-4,7′-thieno[2,3‑c]pyran) Scaffold

Journal of medicinal chemistry, 2014-04, Vol.57 (8), p.3418-3429

2014

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Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective

Drug discovery today, 2017-10, Vol.22 (10), p.1447-1459

2017

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Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (6), p.1478-1483

2017

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Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

Drug metabolism and disposition, 2003-04, Vol.31 (4), p.421

2003

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Use of Osmotic Pumps to Establish the Pharmacokinetic–Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors

Journal of medicinal chemistry, 2016-06, Vol.59 (12), p.5810-5822

2016

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The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice

Toxicology and applied pharmacology, 2006-07, Vol.214 (2), p.178-187

2006

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Absorption Barriers in the Rat Intestinal Mucosa: 2. Application of Physiologically Based Mathematical Models to Quantify Mechanisms of Drug Permeation and Metabolism

Journal of pharmaceutical sciences, 2010-02, Vol.99 (2), p.999-1015

2010

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Analysis of CYP mRNA expression by branched DNA technology

Methods in Enzymology, 2002, Vol.357, p.170-179

2002

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PHARMACOKINETICS, PHARMAODYNAMICS AND DRUG METABOLISM: Absorption Barriers in the Rat Intestinal Mucosa: 1. Application of an In Situ Perfusion Model to Simultaneously Assess Drug Permeation and Metabolism

Journal of pharmaceutical sciences, 2010, Vol.99 (2), p.982-998

2010

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Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (6)

2017

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Preparation of Hepatocytes

Current Protocols in Toxicology, 2001-05, Vol.8 (1), p.14.2.1-14.2.13

2001

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Integrated Lead Optimization: Translational Models as We Advance Toward the Clinic

Translating Molecules into Medicines, p.165-230

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Function and modulation of physical and biological barriers to drug absorption in the rat intestinal mucosa

Mudra, Daniel R

2007

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ProQuest

Function and modulation of physical and biological barriers to drug absorption in the rat intestinal mucosa

Mudra, Daniel R

2007

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Implant success and safety of left atrial appendage closure with the WATCHMAN device: peri-procedural outcomes from the EWOLUTION registry

European heart journal, 2016-08, Vol.37 (31), p.2465-2474

2016

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CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

Drug metabolism and disposition, 2002-07, Vol.30 (7), p.795

2002

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In silico, in vitro and in situ models to assess interplay between CYP3A and P-gp

Preclinical Pharmacokinetic/Pharmacodynamic Modeling and Simulation in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape

Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design

Development of LC-MS/MS-Based Receptor Occupancy Tracers and Positron Emission Tomography Radioligands for the Nociceptin/Orphanin FQ (NOP) Receptor

Absorption Barriers in the Rat Intestinal Mucosa: 1. Application of an In Situ Perfusion Model to Simultaneously Assess Drug Permeation and Metabolism

Translating Molecules into Medicines: Cross-Functional Integration at the Drug Discovery-Development Interface

The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

Absorption Barriers in the Rat Intestinal Mucosa. 3: Effects of Polyethoxylated Solubilizing Agents on Drug Permeation and Metabolism

A Highly Selective Hydantoin Inhibitor of Aggrecanase‑1 and Aggrecanase‑2 with a Low Projected Human Dose

Discovery of a Novel Series of Orally Active Nociceptin/Orphanin FQ (NOP) Receptor Antagonists Based on a Dihydrospiro(piperidine-4,7′-thieno[2,3‑c]pyran) Scaffold

Translational pharmacokinetic-pharmacodynamic analysis in the pharmaceutical industry: an IQ Consortium PK-PD Discussion Group perspective

Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

Use of Osmotic Pumps to Establish the Pharmacokinetic–Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors

The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice

Absorption Barriers in the Rat Intestinal Mucosa: 2. Application of Physiologically Based Mathematical Models to Quantify Mechanisms of Drug Permeation and Metabolism

Analysis of CYP mRNA expression by branched DNA technology

PHARMACOKINETICS, PHARMAODYNAMICS AND DRUG METABOLISM: Absorption Barriers in the Rat Intestinal Mucosa: 1. Application of an In Situ Perfusion Model to Simultaneously Assess Drug Permeation and Metabolism

Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1

Preparation of Hepatocytes

Integrated Lead Optimization: Translational Models as We Advance Toward the Clinic

Function and modulation of physical and biological barriers to drug absorption in the rat intestinal mucosa

Function and modulation of physical and biological barriers to drug absorption in the rat intestinal mucosa

Implant success and safety of left atrial appendage closure with the WATCHMAN device: peri-procedural outcomes from the EWOLUTION registry

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

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