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Kynurenines in the mammalian brain: when physiology meets pathology

Nature reviews. Neuroscience, 2012-07, Vol.13 (7), p.465-477

2012

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The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

Current biology, 2011-06, Vol.21 (11), p.961-966

2011

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Modulation of neurodegeneration by molecular chaperones

Nature reviews. Neuroscience, 2005-01, Vol.6 (1), p.11-22

2005

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Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease

CNS & neurological disorders drug targets, 2010-12, Vol.9 (6), p.791-800

2010

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Flanking sequences profoundly alter polyglutamine toxicity in yeast

Proceedings of the National Academy of Sciences - PNAS, 2006-07, Vol.103 (29), p.11045-11050

2006

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Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease

Progress in neurobiology, 2010-02, Vol.90 (2), p.230-245

2010

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Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease

The Journal of neuroscience, 2012-12, Vol.32 (50), p.18259-18268

2012

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Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders

Biological psychiatry (1969), 2017-11, Vol.82 (10), p.756-765

2017

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Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo

The Journal of biological chemistry, 2010-05, Vol.285 (19), p.14777-14790

2010

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Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice

Biochimica et biophysica acta, 2016-11, Vol.1860 (11), p.2345-2354

2016

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Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

Human molecular genetics, 2006-09, Vol.15 (18), p.2743-2751

2006

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Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

Human molecular genetics, 2010-01, Vol.19 (1), p.65-78

2010

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Protein Misfolding, Amyloid Formation, and Neurodegeneration: A Critical Role for Molecular Chaperones?

Neuron, 2002-07, Vol.35 (1), p.9-12

Muchowski, Paul J.

2002

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Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models

The Journal of neuroscience, 2012-08, Vol.32 (32), p.11109-11119

2012

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Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

Nature communications, 2018-09, Vol.9 (1), p.3191-3191, Article 3191

2018

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Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

Nature structural & molecular biology, 2004-12, Vol.11 (12), p.1215-1222

2004

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Mutant huntingtin impairs immune cell migration in Huntington disease

The Journal of clinical investigation, 2012-12, Vol.122 (12), p.4737-4747

2012

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Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain

The Journal of biological chemistry, 2013-12, Vol.288 (51), p.36554-36566

2013

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A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

Nature genetics, 2005-05, Vol.37 (5), p.526-531

2005

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Identification of Novel Potentially Toxic Oligomers Formed in Vitro from Mammalian-derived Expanded huntingtin Exon-1 Protein

The Journal of biological chemistry, 2012-05, Vol.287 (19), p.16017-16028

2012

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Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models

The Journal of biological chemistry, 2007-08, Vol.282 (33), p.23818-23828

2007

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Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein

Science (American Association for the Advancement of Science), 2003-12, Vol.302 (5651), p.1769-1772

2003

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Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson's Disease

The Journal of neuroscience, 2008-01, Vol.28 (2), p.465-472

2008

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Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease

The Journal of neuroscience, 2012-01, Vol.32 (1), p.133-142

2012

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Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

Kynurenines in the mammalian brain: when physiology meets pathology

The Kynurenine Pathway Modulates Neurodegeneration in a Drosophila Model of Huntington's Disease

Modulation of neurodegeneration by molecular chaperones

Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease

Flanking sequences profoundly alter polyglutamine toxicity in yeast

Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease

Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease

Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders

Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo

Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice

Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

Protein Misfolding, Amyloid Formation, and Neurodegeneration: A Critical Role for Molecular Chaperones?

Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

Mutant huntingtin impairs immune cell migration in Huntington disease

Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

Identification of Novel Potentially Toxic Oligomers Formed in Vitro from Mammalian-derived Expanded huntingtin Exon-1 Protein

Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models

Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein

Induction of the Phase II Detoxification Pathway Suppresses Neuron Loss in Drosophila Models of Parkinson's Disease

Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease

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