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Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets

Accounts of chemical research, 2024-02, Vol.57 (4), p.450-467

2024

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Chlorpyrifos Oxon Activates Glutamate and Lysine for Protein Cross-linking

Chemical research in toxicology, 2023-01, Vol.36 (1), p.112-121

2023

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Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2549-2567

2014

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Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs

Journal of natural products (Washington, D.C.), 2017-02, Vol.80 (2), p.278-289

2017

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Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR‑6

Journal of medicinal chemistry, 2020-09, Vol.63 (17), p.9360-9390

2020

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Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies

Journal of medicinal chemistry, 2015-08, Vol.58 (15), p.6018-6032

2015

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Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds

Journal of medicinal chemistry, 2009-09, Vol.52 (17), p.5365-5379

2009

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Amyloid Pan-inhibitors: One Family of Compounds To Cope with All Conformational Diseases

ACS chemical neuroscience, 2019-03, Vol.10 (3), p.1311-1317

2019

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Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation

Journal of medicinal chemistry, 2008-06, Vol.51 (12), p.3588-3598

2008

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Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases

Journal of medicinal chemistry, 2012-01, Vol.55 (2), p.661-669

2012

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Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer’s Disease

ACS chemical neuroscience, 2022-12, Vol.13 (23), p.3314-3329

2022

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The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures

BMC biology, 2022-10, Vol.20 (1), p.1-197, Article 197

2022

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Insertion of Isocyanides into N−Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds

Angewandte Chemie (International ed.), 2016-07, Vol.55 (31), p.8994-8998

International ed. in English, 2016

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Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice

International journal of molecular sciences, 2018-09, Vol.19 (9), p.2615

2018

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A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors

European journal of medicinal chemistry, 2019-10, Vol.180, p.613-626

2019

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Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases

Molecules (Basel, Switzerland), 2018-01, Vol.23 (1), p.177

2018

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A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer's disease exacerbated with high fat diet

Cell & bioscience, 2023-03, Vol.13 (1), p.52-52, Article 52

2023

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Undifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxide

PloS one, 2013-09, Vol.8 (9), p.e74344

2013

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We've Come a Long Way, Baby: Announcing a Special Issue to Commemorate the Publication of Molecule's 20,000th Paper

Molecules (Basel, Switzerland), 2019-12, Vol.25 (1), p.173

2019

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Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation

Basic & clinical pharmacology & toxicology, 2018-01, Vol.122 (1), p.94-103

2018

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Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.634

2018

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Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound

Molecules (Basel, Switzerland), 2015-03, Vol.20 (3), p.4492-4515

2015

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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2

Molecules (Basel, Switzerland), 2018-01, Vol.23 (1), p.65

2018

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Shogaol–huprine hybrids: Dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties

Bioorganic & medicinal chemistry, 2014-10, Vol.22 (19), p.5298-5307

2014

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Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets

Chlorpyrifos Oxon Activates Glutamate and Lysine for Protein Cross-linking

Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

Combined in Vitro Cell-Based/in Silico Screening of Naturally Occurring Flavonoids and Phenolic Compounds as Potential Anti-Alzheimer Drugs

Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR‑6

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies

Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds

Amyloid Pan-inhibitors: One Family of Compounds To Cope with All Conformational Diseases

Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation

Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases

Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer’s Disease

The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures

Insertion of Isocyanides into N−Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds

Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice

A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors

Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases

A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer's disease exacerbated with high fat diet

Undifferentiated and differentiated PC12 cells protected by huprines against injury induced by hydrogen peroxide

We've Come a Long Way, Baby: Announcing a Special Issue to Commemorate the Publication of Molecule's 20,000th Paper

Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation

Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis

Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2

Shogaol–huprine hybrids: Dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties

Novel Huprine Derivatives with Inhibitory Activity toward β-Amyloid Aggregation and Formation as Disease-Modifying Anti-Alzheimer Drug Candidates

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