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Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease

Current medicinal chemistry, 2008-10, Vol.15 (24), p.2433-2455

Muñoz-Torrero, D

2008

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Dimeric and hybrid anti-Alzheimer drug candidates

Current medicinal chemistry, 2006-01, Vol.13 (4), p.399-422

2006

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Human disease and drug pharmacology, complex as real life

Current medicinal chemistry, 2013-04, Vol.20 (13), p.1623-1634

2013

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AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: Studies in cognitively poor middle-aged mice

Behavioural brain research, 2015-06, Vol.286, p.97-103

2015

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Huprine X and Huperzine A Improve Cognition and Regulate Some Neurochemical Processes Related with Alzheimer’s Disease in Triple Transgenic Mice (3xTg-AD)

Neuro-degenerative diseases, 2013-01, Vol.11 (3), p.129-140

2013

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Acetylcholinesterase triggers the aggregation of PrP 106–126

Biochemical and biophysical research communications, 2006-07, Vol.346 (1), p.89-94

2006

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Thioflavin-S staining of bacterial inclusion bodies for the fast, simple, and inexpensive screening of amyloid aggregation inhibitors

Current medicinal chemistry, 2014-03, Vol.21 (9), p.1152-1159

2014

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Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors

Brain research, 2005-11, Vol.1061 (2), p.73-79

2005

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Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation

Journal of molecular neuroscience, 2006-01, Vol.30 (1-2), p.89-90

2006

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3D Structure of Torpedo californica Acetylcholinesterase Complexed with Huprine X at 2.1 Å Resolution: Kinetic and Molecular Dynamic Correlates

Biochemistry (Easton), 2002-03, Vol.41 (9), p.2970-2981

2002

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Cholinergic drugs in pharmacotherapy of Alzheimer's disease

Mini reviews in medicinal chemistry, 2002-02, Vol.2 (1), p.11-25

2002

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Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease

Mini reviews in medicinal chemistry, 2001-07, Vol.1 (2), p.163

2001

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New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease

Journal of medicinal chemistry, 2000-11, Vol.43 (24), p.4657-4666

2000

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Behavioural effects and regulation of PKCα and MAPK by huprine X in middle aged mice

Pharmacology, biochemistry and behavior, 2010-06, Vol.95 (4), p.485-493

2010

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Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease

Bioorganic & medicinal chemistry, 1998-04, Vol.6 (4), p.427-440

1998

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Synthesis, in Vitro Pharmacology, and Molecular Modeling of syn-Huprines as Acetylcholinesterase Inhibitors

Journal of medicinal chemistry, 2001-12, Vol.44 (26), p.4733-4736

2001

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The pharmacology of novel acetylcholinesterase inhibitors, (±)-huprines Y and X, on the Torpedo electric organ

European journal of pharmacology, 2001-06, Vol.421 (2), p.77-84

2001

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Synthesis and evaluation of tacrine-related compounds for the treatment of Alzheimer's disease

European journal of medicinal chemistry, 1994, Vol.29 (3), p.205-221

1994

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Effects of (±)-huprine Y and (±)-huprine Z, two new anticholinesterasic drugs, on muscarinic receptors

Neuroscience letters, 2005-05, Vol.379 (2), p.106-109

2005

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(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration

Journal of Alzheimer's disease, 2004-12, Vol.6 (6), p.577-583

2004

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Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease

Molecular pharmacology, 2000-02, Vol.57 (2), p.409-417

2000

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Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease

Journal of medicinal chemistry, 1999-08, Vol.42 (17), p.3227-3242

1999

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Effects of age on the risk of dying from pulmonary embolism or bleeding during treatment of deep vein thrombosis

Journal of vascular surgery, 2011-12, Vol.54 (6), p.26S-32S

2011

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rs1801275 Interleukin-4 receptor alpha polymorphism in familial hypercholesterolemia

Journal of clinical lipidology, 2014-07, Vol.8 (4), p.418-422

2014

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Attainment of LDL-Cholesterol Treatment Goals in Patients With Familial Hypercholesterolemia

Journal of the American College of Cardiology, 2016-03, Vol.67 (11), p.1278-1285

2016

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Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease

Dimeric and hybrid anti-Alzheimer drug candidates

Human disease and drug pharmacology, complex as real life

AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: Studies in cognitively poor middle-aged mice

Huprine X and Huperzine A Improve Cognition and Regulate Some Neurochemical Processes Related with Alzheimer’s Disease in Triple Transgenic Mice (3xTg-AD)

Acetylcholinesterase triggers the aggregation of PrP 106–126

Thioflavin-S staining of bacterial inclusion bodies for the fast, simple, and inexpensive screening of amyloid aggregation inhibitors

Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors

Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation

3D Structure of Torpedo californica Acetylcholinesterase Complexed with Huprine X at 2.1 Å Resolution: Kinetic and Molecular Dynamic Correlates

Cholinergic drugs in pharmacotherapy of Alzheimer's disease

Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease

New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease

Behavioural effects and regulation of PKCα and MAPK by huprine X in middle aged mice

Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease

Synthesis, in Vitro Pharmacology, and Molecular Modeling of syn-Huprines as Acetylcholinesterase Inhibitors

The pharmacology of novel acetylcholinesterase inhibitors, (±)-huprines Y and X, on the Torpedo electric organ

Synthesis and evaluation of tacrine-related compounds for the treatment of Alzheimer's disease

Effects of (±)-huprine Y and (±)-huprine Z, two new anticholinesterasic drugs, on muscarinic receptors

(+/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration

Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease

Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease

Effects of age on the risk of dying from pulmonary embolism or bleeding during treatment of deep vein thrombosis

rs1801275 Interleukin-4 receptor alpha polymorphism in familial hypercholesterolemia

Attainment of LDL-Cholesterol Treatment Goals in Patients With Familial Hypercholesterolemia

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