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Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain

PloS one, 2014-09, Vol.9 (9), p.e105895-e105895

2014

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Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

PloS one, 2018-05, Vol.13 (5), p.e0196791-e0196791

2018

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Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel Na V 1.8 with a Unique Mechanism of Action

Molecular pharmacology, 2024-03, Vol.105 (3), p.233-249

2024

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Genome-wide analysis of gene expression in primate taste buds reveals links to diverse processes

PloS one, 2009-07, Vol.4 (7), p.e6395-e6395

2009

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Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2299-2314

2015

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Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel

Journal of medicinal chemistry, 2015-03, Vol.58 (5), p.2299-2314

2015

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Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7818-7839

2016

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Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx‑1

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2704-2717

2016

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Voltage-gated sodium channels in taste bud cells

BMC neuroscience, 2009-03, Vol.10 (1), p.20-20, Article 20

2009

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.5990-6017

2017

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Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations

PloS one, 2009-12, Vol.4 (12), p.e7682-e7682

2009

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.5969-5989

2017

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Discovery of pyridyl urea sulfonamide inhibitors of NaV1.7

Bioorganic & medicinal chemistry letters, 2022-10, Vol.73, p.128892-128892, Article 128892

2022

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PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache?

Pain (Amsterdam), 2020-07, Vol.161 (7), p.1670-1681

2020

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Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx‑V Peptide 5‑Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis

Journal of medicinal chemistry, 2018-11, Vol.61 (21), p.9500-9512

2018

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The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (15), p.3477-3485

2017

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Endoplasmic Reticulum Retention, Degradation, and Aggregation of Olfactory G‐Protein Coupled Receptors

Traffic (Copenhagen, Denmark), 2003-06, Vol.4 (6), p.416-433

2003

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement

ACS medicinal chemistry letters, 2016-12, Vol.7 (12), p.1062-1067

2016

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Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (21), p.4866-4871

2015

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1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (11), p.2103-2108

2018

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Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (16), p.3817-3824

2017

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Rab1 Recruitment of p115 into a cis-SNARE Complex: Programming Budding COPII Vesicles for Fusion

Science (American Association for the Advancement of Science), 2000-07, Vol.289 (5478), p.444-448

2000

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Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats

Molecular pain, 2016, Vol.12, p.174480691667776

2016

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Engineering Antibody Reactivity for Efficient Derivatization to Generate NaV1.7 Inhibitory GpTx‑1 Peptide–Antibody Conjugates

ACS chemical biology, 2017-09, Vol.12 (9), p.2427-2435

2017

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Discovery of Tarantula Venom-Derived Na V 1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis

Journal of medicinal chemistry, 2018-11, Vol.61 (21), p.9500-9512

2018

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Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain

Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel Na V 1.8 with a Unique Mechanism of Action

Genome-wide analysis of gene expression in primate taste buds reveals links to diverse processes

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel

Application of a Parallel Synthetic Strategy in the Discovery of Biaryl Acyl Sulfonamides as Efficient and Selective NaV1.7 Inhibitors

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx‑1

Voltage-gated sodium channels in taste bud cells

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities

Discovery of pyridyl urea sulfonamide inhibitors of NaV1.7

PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache?

Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx‑V Peptide 5‑Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis

The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement

Endoplasmic Reticulum Retention, Degradation, and Aggregation of Olfactory G‐Protein Coupled Receptors

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement

Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition

Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors

Rab1 Recruitment of p115 into a cis-SNARE Complex: Programming Budding COPII Vesicles for Fusion

Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats

Engineering Antibody Reactivity for Efficient Derivatization to Generate NaV1.7 Inhibitory GpTx‑1 Peptide–Antibody Conjugates

Discovery of Tarantula Venom-Derived Na V 1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis

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