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Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility
Biochemical journal, 2015-10, Vol.471 (2), p.131-153
2015
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Tumour Hypoxia-Mediated Immunosuppression: Mechanisms and Therapeutic Approaches to Improve Cancer Immunotherapy
Cells (Basel, Switzerland), 2021-04, Vol.10 (5), p.1006
2021
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Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302
Molecular cancer therapeutics, 2012-03, Vol.11 (3), p.740-751
2012
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Use of a Luciferase-Expressing Orthotopic Rat Brain Tumor Model to Optimize a Targeted Irradiation Strategy for Efficacy Testing with Temozolomide
Cancers, 2020-06, Vol.12 (6), p.1585
2020
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Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications
Pharmaceuticals (Basel, Switzerland), 2022-02, Vol.15 (2), p.185
2022
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Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3
Pharmaceuticals (Basel, Switzerland), 2021-11, Vol.14 (12), p.1231
2021
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Advancing Clostridia to Clinical Trial: Past Lessons and Recent Progress
Cancers, 2016-06, Vol.8 (7), p.63
2016
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Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery
Molecular diagnosis & therapy, 2024-03, Vol.28 (2), p.141-151
2024
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Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy
Cell chemical biology, 2017-03, Vol.24 (3), p.391-403
2017
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Tumor-targeting bacteria as immune stimulants - the future of cancer immunotherapy?
Critical reviews in microbiology, 2024-02, p.1-16
2024
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Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506
Molecular cancer therapeutics, 2021-12, Vol.20 (12), p.2372-2383
2021
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Design and Biological Evaluation of Piperazine-Bearing Nitrobenzamide Hypoxia/GDEPT Prodrugs: The Discovery of CP-506
ACS medicinal chemistry letters, 2023-11, Vol.14 (11), p.1517-1523
2023
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Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours
Cancer gene therapy, 2022-02, Vol.29 (2), p.178-188
2022
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Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy
Biochemistry (Easton), 2019-09, Vol.58 (35), p.3700-3710
2019
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Bioreductive prodrugs as cancer therapeutics： targeting tumor hypoxia
Ai zheng, 2014-02, Vol.33 (2), p.80-86
2014
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Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit
Cancer gene therapy, 2022-07, Vol.29 (7), p.1021-1032
2022
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Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A
Biochemical pharmacology, 2013-04, Vol.85 (8), p.1091-1103
2013
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Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy
Biochemical pharmacology, 2016-09, Vol.116, p.176-187
2016
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Pseudomonas aeruginosa NfsB and nitro-CBI-DEI--a promising enzyme/prodrug combination for gene directed enzyme prodrug therapy
Molecular cancer, 2013-06, Vol.12 (1), p.58-58, Article 58
2013
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Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411 NTR leading to therapeutic benefit
Cancer gene therapy, 2022-07, Vol.29 (7), p.1021
2022
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Abstract B88: Discovery, characterization, and engineering of bacterial nitroreductases for gene-directed enzyme prodrug therapy
Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.B88-B88
2011
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