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Identification of imidazo[1,2- b ]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling
MedChemComm, 2017-04, Vol.8 (4), p.700-712
2017
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Mechanistic Implications of Nickel-Catalyzed Reductive Coupling of Aldehydes and Chiral 1,6-Enynes
Organic letters, 2006-02, Vol.8 (3), p.455-458
2006
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Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signallingThe authors declare no competing interests.Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00560h
2017-04
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Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00560h
MedChemComm, 2016-12, Vol.8 (4), p.700-712
2016
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Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165
Journal of medicinal chemistry, 2019-10, Vol.62 (20), p.8973-8995
2019
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LBA36 Nivolumab (N) + ipilimumab (I) vs EXTREME as first-line (1L) treatment (tx) for recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): Final results of CheckMate 651
Annals of oncology, 2021-09, Vol.32, p.S1310-S1311
2021
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Identification of N‑Methyl Nicotinamide and N‑Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2)
Journal of medicinal chemistry, 2019-10, Vol.62 (20), p.8953-8972
2019
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Spatial and Seasonal Ionospheric Error Growth in DGPS Measurement: A Case Study in Malaysia
Journal of navigation, 2015-11, Vol.68 (6), p.1105-1119
2015
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Efficacy and Safety of Nivolumab Plus Ipilimumab vs Nivolumab Alone for Treatment of Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: The Phase 2 CheckMate 714 Randomized Clinical Trial
JAMA oncology, 2023-06, Vol.9 (6), p.779
2023
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Identification of Imidazo[1,2‑b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors
ACS medicinal chemistry letters, 2019-03, Vol.10 (3), p.383-388
2019
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Inactivation of transforming DNA by a transient product of the interaction of Cu 2+ and hydroquinone
Biochemical and biophysical research communications, 1982, Vol.109 (3), p.888-894
1982
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Inactivation of transforming DNA by a transient product of the interaction of Cu2+ and hydroquinone
Biochemical and biophysical research communications, 1982-12, Vol.109 (3), p.888-894
1982
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