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Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

Journal of medicinal chemistry, 2008-05, Vol.51 (10), p.2871-2878

2008

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Synthesis and Spectrum of the Neoglycoside ACHN-490

Antimicrobial Agents and Chemotherapy, 2010-11, Vol.54 (11), p.4636-4642

2010

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Exploring the active site of the Streptococcus pneumoniae topoisomerase IV–DNA cleavage complex with novel 7,8-bridged fluoroquinolones

Open biology, 2016-09, Vol.6 (9), p.160157

2016

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Biased Complement Diversity Selection for Effective Exploration of Chemical Space in Hit-Finding Campaigns

Journal of chemical information and modeling, 2019-05, Vol.59 (5), p.1709-1714

2019

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In Vitro and In Vivo Properties of CUO246, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor

Antimicrobial agents and chemotherapy, 2022-12, Vol.66 (12), p.e0092122-e0092122

2022

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Challenges of antibacterial drug discovery

ARKIVOC free online journal of organic chemistry, 2019-01, Vol.2019 (4), p.227-244

2019

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Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae – Identification of LYS228

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (4), p.748-755

2018

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New aminoglycoside antibiotics

Expert opinion on therapeutic patents, 2010-10, Vol.20 (10), p.1321-1341

2010

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Antibacterial Activity of Enrofloxacin and Ciprofloxacin Derivatives of β-Octaarginine

Chemistry & biodiversity, 2015-02, Vol.12 (2), p.179-193

2015

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Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones

ChemMedChem, 2017-10, Vol.12 (20), p.1687-1692

2017

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Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation

Science (American Association for the Advancement of Science), 1987-10, Vol.238 (4827), p.645-650

1987

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Size Matters and How You Measure It: A Gram-Negative Antibacterial Example Exceeding Typical Molecular Weight Limits

ACS infectious diseases, 2019-10, Vol.5 (10), p.1688-1692

2019

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Antisense Oligonucleotides

Accounts of chemical research, 1995-09, Vol.28 (9), p.366-374

1995

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DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1253-1257

2004

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Cover Feature: Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones (ChemMedChem 20/2017)

ChemMedChem, 2017-10, Vol.12 (20), p.1656-1656

2017

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Second Generation of Antisense Oligonucleotides: From Nuclease Resistance to Biological Efficacy in Animals

Chimia, 1996-04, Vol.50 (4), p.168

1996

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Macrocyclic Inhibitors for Peptide Deformylase: A Structure−Activity Relationship Study of the Ring Size

Journal of medicinal chemistry, 2004-09, Vol.47 (20), p.4941-4949

2004

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Dual Recognition of Double-Stranded DNA by 2′-Aminoethoxy-Modified Oligonucleotides

Angewandte Chemie (International ed.), 1998-05, Vol.37 (9), p.1288-1291

1998

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DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1259-1263

2004

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DNA Binding Ligands Targeting Drug-Resistant Bacteria: Structure, Activity, and Pharmacology

Journal of medicinal chemistry, 2003-08, Vol.46 (18), p.3914-3929

2003

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DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1253-1257

2004

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DNA Binding Ligands with Improved in Vitro and in Vivo Potency against Drug-Resistant Staphylococcus aureus

Journal of medicinal chemistry, 2004-08, Vol.47 (18), p.4352-4355

2004

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DNA Binding Ligands with Excellent Antibiotic Potency Against Drug-Resistant Gram-Positive Bacteria

Bioorganic & medicinal chemistry letters, 2002-09, Vol.12 (18), p.2591-2594

2002

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Creating RNA Bulges: Cleavage of RNA in RNA/DNA Duplexes by Metal Ion Catalysis

Biochemistry (Easton), 1996-12, Vol.35 (51), p.16591-16600

1996

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Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

Synthesis and Spectrum of the Neoglycoside ACHN-490

Exploring the active site of the Streptococcus pneumoniae topoisomerase IV–DNA cleavage complex with novel 7,8-bridged fluoroquinolones

Biased Complement Diversity Selection for Effective Exploration of Chemical Space in Hit-Finding Campaigns

In Vitro and In Vivo Properties of CUO246, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor

Challenges of antibacterial drug discovery

Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae – Identification of LYS228

Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety

New aminoglycoside antibiotics

Antibacterial Activity of Enrofloxacin and Ciprofloxacin Derivatives of β-Octaarginine

Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones

Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation

Size Matters and How You Measure It: A Gram-Negative Antibacterial Example Exceeding Typical Molecular Weight Limits

Antisense Oligonucleotides

DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives

Cover Feature: Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones (ChemMedChem 20/2017)

Second Generation of Antisense Oligonucleotides: From Nuclease Resistance to Biological Efficacy in Animals

Macrocyclic Inhibitors for Peptide Deformylase: A Structure−Activity Relationship Study of the Ring Size

Dual Recognition of Double-Stranded DNA by 2′-Aminoethoxy-Modified Oligonucleotides

DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives

DNA Binding Ligands Targeting Drug-Resistant Bacteria: Structure, Activity, and Pharmacology

DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives

DNA Binding Ligands with Improved in Vitro and in Vivo Potency against Drug-Resistant Staphylococcus aureus

DNA Binding Ligands with Excellent Antibiotic Potency Against Drug-Resistant Gram-Positive Bacteria

Creating RNA Bulges: Cleavage of RNA in RNA/DNA Duplexes by Metal Ion Catalysis

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