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Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis

Annals of the rheumatic diseases, 2008-12, Vol.67 (12), p.1750-1758

2008

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The non-aggregated aggrecan in the human intervertebral disc can arise by a non-proteolytic mechanism

European cells & materials, 2014-09, Vol.28, p.129-36; discussion 136

2014

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Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage

European cells & materials, 2011-01, Vol.21, p.31-45

2011

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Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment

The EMBO journal, 1996-10, Vol.15 (20), p.5492-5503

1996

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Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice

Human molecular genetics, 2006-06, Vol.15 (11), p.1783-1792

2006

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Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels

Oncogene, 2008-08, Vol.27 (37), p.4973-4985

2008

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Peroxisome Proliferator–Activated Receptor δ Promotes the Progression of Posttraumatic Osteoarthritis in a Mouse Model

Arthritis & rheumatology (Hoboken, N.J.), 2015-02, Vol.67 (2), p.454-464

2015

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Proteolysis of human bone collagen by cathepsin K: characterization of the cleavage sites generating the cross-linked N-telopeptide neoepitope

Bone (New York, N.Y.), 2000, Vol.26 (3), p.241-247

2000

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Early cathepsin K degradation of type II collagen in vitro and in vivo in articular cartilage

Osteoarthritis and cartilage, 2016-08, Vol.24 (8), p.1461-1469

2016

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Maturation of human procathepsin B. Proenzyme activation and proteolytic processing of the precursor to the mature proteinase, in vitro, are primarily unimolecular processes

The Journal of biological chemistry, 1994-04, Vol.269 (17), p.13030-13035

1994

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C2K77 ELISA detects cleavage of type II collagen by cathepsin K in equine articular cartilage

Osteoarthritis and cartilage, 2017-12, Vol.25 (12), p.2119-2126

2017

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Age-related changes in fibromodulin and lumican in human intervertebral discs

Spine (Philadelphia, Pa. 1976), 1999-09, Vol.24 (17), p.1765-1771

1999

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Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activity

Biochimie, 1997-11, Vol.79 (11), p.645-652

1997

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Rat procathepsin B. Proteolytic processing to the mature form in vitro

The Journal of biological chemistry, 1992-08, Vol.267 (22), p.15993-15999

1992

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Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M

Osteoarthritis and cartilage, 2008-01, Vol.16 (1), p.98-104

2008

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Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro

Biochemical journal, 1995-02, Vol.305 ( Pt 3) (3), p.799-804

1995

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Non-proteoglycan forms of biglycan increase with age in human articular cartilage

Biochemical journal, 1993-10, Vol.295 (2), p.421-426

1993

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The Occluding Loop of Cathepsin B Prevents Its Effective Inhibition by Human Kininogens

Journal of molecular biology, 2010-07, Vol.400 (5), p.1022-1035

2010

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Evidence to suggest that cathepsin K degrades articular cartilage in naturally occurring equine osteoarthritis

Osteoarthritis and cartilage, 2009-03, Vol.17 (3), p.375-383

2009

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Differential changes in the association and dissociation rate constants for binding of cystatins to target proteinases occurring on N-terminal truncation of the inhibitors indicate that the interaction mechanism varies with different enzymes

Biochemical journal, 1994-04, Vol.299 (1), p.219-225

1994

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The septoclast, a cathepsin B-rich cell involved in the resorption of growth plate cartilage

The journal of histochemistry and cytochemistry, 1995-05, Vol.43 (5), p.525-536

1995

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Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme

The Journal of biological chemistry, 1994-04, Vol.269 (17), p.13036-13040

1994

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Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein

Biochemical journal, 1993-10, Vol.295 (2), p.595-598

1993

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Cathepsin B

The international journal of biochemistry & cell biology, 1997-05, Vol.29 (5), p.715-720

1997

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Identification of human intervertebral disc stromelysin and its involvement in matrix degradation

Journal of orthopaedic research, 1991-07, Vol.9 (4), p.568-575

1991

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Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis

The non-aggregated aggrecan in the human intervertebral disc can arise by a non-proteolytic mechanism

Involvement of ADAMTS5 and hyaluronidase in aggrecan degradation and release from OSM-stimulated cartilage

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment

Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice

Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels

Peroxisome Proliferator–Activated Receptor δ Promotes the Progression of Posttraumatic Osteoarthritis in a Mouse Model

Proteolysis of human bone collagen by cathepsin K: characterization of the cleavage sites generating the cross-linked N-telopeptide neoepitope

Early cathepsin K degradation of type II collagen in vitro and in vivo in articular cartilage

Maturation of human procathepsin B. Proenzyme activation and proteolytic processing of the precursor to the mature proteinase, in vitro, are primarily unimolecular processes

C2K77 ELISA detects cleavage of type II collagen by cathepsin K in equine articular cartilage

Age-related changes in fibromodulin and lumican in human intervertebral discs

Proregion structure of members of the papain superfamily. Mode of inhibition of enzymatic activity

Rat procathepsin B. Proteolytic processing to the mature form in vitro

Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M

Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro

Non-proteoglycan forms of biglycan increase with age in human articular cartilage

The Occluding Loop of Cathepsin B Prevents Its Effective Inhibition by Human Kininogens

Evidence to suggest that cathepsin K degrades articular cartilage in naturally occurring equine osteoarthritis

Differential changes in the association and dissociation rate constants for binding of cystatins to target proteinases occurring on N-terminal truncation of the inhibitors indicate that the interaction mechanism varies with different enzymes

The septoclast, a cathepsin B-rich cell involved in the resorption of growth plate cartilage

Noncovalent complexes between the lysosomal proteinase cathepsin B and its propeptide account for stable, extracellular, high molecular mass forms of the enzyme

Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein

Cathepsin B

Identification of human intervertebral disc stromelysin and its involvement in matrix degradation

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