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Proteostasis and the Aging Proteome in Health and Disease

The journals of gerontology. Series A, Biological sciences and medical sciences, 2014-06, Vol.69 (Suppl_1), p.S33-S38

2014

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The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj‐1 have distinct roles in recognition of a non‐native protein and protein refolding

The EMBO journal, 1996-06, Vol.15 (12), p.2969-2979

1996

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Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection

Nature biotechnology, 1998-09, Vol.16 (9), p.833-838

1998

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The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis

Molecular and Cellular Biology, 2000-10, Vol.20 (19), p.7146-7159

2000

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The stress of protein misfolding: from single cells to multicellular organisms

Cold Spring Harbor perspectives in biology, 2011-06, Vol.3 (6), p.a009704-a009704

2011

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Cells in Stress: Transcriptional Activation of Heat Shock Genes

Science (American Association for the Advancement of Science), 1993-03, Vol.259 (5100), p.1409-1410

Morimoto, Richard I.

1993

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HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator

Molecular and Cellular Biology, 1997-01, Vol.17 (1), p.469-481

1997

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Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress

Molecular and Cellular Biology, 1993-03, Vol.13 (3), p.1392-1407

1993

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Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses

The Journal of biological chemistry, 1992-11, Vol.267 (31), p.21987-21990

1992

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Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation

Molecular and Cellular Biology, 1997-04, Vol.17 (4), p.2107-2115

1997

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Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23

Science (American Association for the Advancement of Science), 1996-12, Vol.274 (5293), p.1718-1720

1996

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Molecular chaperones and the stress of oncogenesis

Oncogene, 2004-04, Vol.23 (16), p.2907-2918

2004

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Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

Genes & development, 1998-12, Vol.12 (24), p.3788-3796

Morimoto, R I

1998

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Stress-Specific Activation and Repression of Heat Shock Factors 1 and 2

Molecular and Cellular Biology, 2001-11, Vol.21 (21), p.7163-7171

2001

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Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway

Molecular and Cellular Biology, 1993-04, Vol.13 (4), p.1983-1997

1993

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Conserved Features of Eukaryotic hsp70 Genes Revealed by Comparison with the Nucleotide Sequence of Human hsp70

Proceedings of the National Academy of Sciences - PNAS, 1985-10, Vol.82 (19), p.6455-6459

1985

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Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death

JNCI : Journal of the National Cancer Institute, 2000-10, Vol.92 (19), p.1564-1572

2000

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Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription

Molecular and Cellular Biology, 1994-03, Vol.14 (3), p.2087-2099

1994

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Arachidonate is a Potent Modulator of Human Heat Shock Gene Transcription

Proceedings of the National Academy of Sciences - PNAS, 1994-03, Vol.91 (6), p.2280-2284

1994

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The Threshold for Polyglutamine-Expansion Protein Aggregation and Cellular Toxicity is Dynamic and Influenced by Aging in Caenorhabditis elegans

Proceedings of the National Academy of Sciences - PNAS, 2002-08, Vol.99 (16), p.10417-10422

2002

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Dynamic Remodeling of Transcription Complexes by Molecular Chaperones

Cell, 2002-08, Vol.110 (3), p.281-284

Morimoto, Richard I.

2002

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Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures

Genes & development, 1991-11, Vol.5 (11), p.2117-2127

1991

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Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells

Molecular and Cellular Biology, 1988-11, Vol.8 (11), p.4736-4744

1988

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Expression of heat shock factor 2 in mouse testis: potential role as a regulator of heat-shock protein gene expression during spermatogenesis

Biology of reproduction, 1994-06, Vol.50 (6), p.1334-1343

1994

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Effect of Sodium Salicylate on the Human Heat Shock Response

Science (American Association for the Advancement of Science), 1992-03, Vol.255 (5049), p.1243-1245

1992

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Proteostasis and the Aging Proteome in Health and Disease

The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj‐1 have distinct roles in recognition of a non‐native protein and protein refolding

Stress-inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection

The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis

The stress of protein misfolding: from single cells to multicellular organisms

Cells in Stress: Transcriptional Activation of Heat Shock Genes

HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator

Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress

Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses

Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation

Molecular Chaperone Machines: Chaperone Activities of the Cyclophilin Cyp-40 and the Steroid Aporeceptor-Associated Protein p23

Molecular chaperones and the stress of oncogenesis

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

Stress-Specific Activation and Repression of Heat Shock Factors 1 and 2

Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway

Conserved Features of Eukaryotic hsp70 Genes Revealed by Comparison with the Nucleotide Sequence of Human hsp70

Role of the Heat Shock Response and Molecular Chaperones in Oncogenesis and Cell Death

Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription

Arachidonate is a Potent Modulator of Human Heat Shock Gene Transcription

The Threshold for Polyglutamine-Expansion Protein Aggregation and Cellular Toxicity is Dynamic and Influenced by Aging in Caenorhabditis elegans

Dynamic Remodeling of Transcription Complexes by Molecular Chaperones

Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures

Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells

Expression of heat shock factor 2 in mouse testis: potential role as a regulator of heat-shock protein gene expression during spermatogenesis

Effect of Sodium Salicylate on the Human Heat Shock Response

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