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Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

Science translational medicine, 2013-10, Vol.5 (206), p.206ra138

2013

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M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

The Journal of clinical investigation, 2017-02, Vol.127 (2), p.487-499

2017

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Intranasally delivered mesenchymal stromal cells decrease glial inflammation early in prion disease

Frontiers in neuroscience, 2023-05, Vol.17, p.1158408-1158408

2023

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Adipose-derived mesenchymal stromal cells decrease prion-induced glial inflammation in vitro

Scientific reports, 2022-12, Vol.12 (1), p.22567-14, Article 22567

2022

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Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy

Journal of neuroinflammation, 2024-07, Vol.21 (1), p.182-18, Article 182

2024

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Gliosis, misfolded protein aggregation, and neuronal loss in a guinea pig model of pulmonary tuberculosis

Frontiers in neuroscience, 2023-05, Vol.17, p.1157652-1157652

2023

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Biological agents and the aging brain: glial inflammation and neurotoxic signaling

Frontiers in aging, 2023-08, Vol.4, p.1244149-1244149

2023

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Activated gliosis, accumulation of amyloid β, and hyperphosphorylation of tau in aging canines with and without cognitive decline

Frontiers in aging neuroscience, 2023-04, Vol.15, p.1128521-1128521

2023

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Assessment of risk factors in dogs with presumptive advanced canine cognitive dysfunction

Frontiers in veterinary science, 2022-10, Vol.9, p.958488-958488

2022

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Effects of Mycobacterium vaccae NCTC 11659 and Lipopolysaccharide Challenge on Polarization of Murine BV-2 Microglial Cells

International journal of molecular sciences, 2023-12, Vol.25 (1), p.474

2023

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PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

Acta neuropathologica, 2015-11, Vol.130 (5), p.633-642

2015

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Network Simulations Reveal Molecular Signatures of Vulnerability to Age-Dependent Stress and Tau Accumulation

Frontiers in molecular biosciences, 2020-10, Vol.7, p.590045-590045

2020

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Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice

Brain (London, England : 1878), 2017-06, Vol.140 (6), p.1768-1783

2017

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Sustained translational repression by eIF2α-P mediates prion neurodegeneration

Nature (London), 2012-05, Vol.485 (7399), p.507-511

2012

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Dysfunction and recovery of synapses in prion disease: implications for neurodegeneration

Biochemical Society transactions, 2010-04, Vol.38 (2), p.482-487

2010

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The Chaperone Grp78 in Protein Folding Disorders of the Nervous System

Neurochemical research, 2015-02, Vol.40 (2), p.329-335

2015

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RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration

Nature (London), 2015-02, Vol.518 (7538), p.236-239

2015

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Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice

Proceedings of the National Academy of Sciences - PNAS, 2019-06, Vol.116 (25), p.12478-12487

2019

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Molecular Mechanisms of Chronic Wasting Disease Prion Propagation

Cold Spring Harbor perspectives in medicine, 2018-06, Vol.8 (6), p.a024448

2018

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Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Nitric-Oxide Synthase 2 Expression in Astrocytes by a Novel Diindolylmethane Analog Protects Striatal Neurons against Apoptosis

Molecular pharmacology, 2009-01, Vol.75 (1), p.35-43

2009

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Insights into Mechanisms of Transmission and Pathogenesis from Transgenic Mouse Models of Prion Diseases

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1658, p.219

2017

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Targeted-Neuroinflammation Mitigation Using Inflammasome-Inhibiting Nanoligomers is Therapeutic in an Experimental Autoimmune Encephalomyelitis Mouse Model

ACS chemical neuroscience, 2024-04, Vol.15 (7), p.1596-1608

2024

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Tissue-specific biochemical differences between chronic wasting disease prions isolated from free-ranging white-tailed deer (Odocoileus virginianus)

The Journal of biological chemistry, 2022-04, Vol.298 (4), p.101834, Article 101834

2022

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Compensatory Expression of Nur77 and Nurr1 Regulates NF- κ B-Dependent Inflammatory Signaling in Astrocytes

Molecular pharmacology, 2018-10, Vol.94 (4), p.1174-1186

2018

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Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

Intranasally delivered mesenchymal stromal cells decrease glial inflammation early in prion disease

Adipose-derived mesenchymal stromal cells decrease prion-induced glial inflammation in vitro

Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy

Gliosis, misfolded protein aggregation, and neuronal loss in a guinea pig model of pulmonary tuberculosis

Biological agents and the aging brain: glial inflammation and neurotoxic signaling

Activated gliosis, accumulation of amyloid β, and hyperphosphorylation of tau in aging canines with and without cognitive decline

Assessment of risk factors in dogs with presumptive advanced canine cognitive dysfunction

Effects of Mycobacterium vaccae NCTC 11659 and Lipopolysaccharide Challenge on Polarization of Murine BV-2 Microglial Cells

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

Network Simulations Reveal Molecular Signatures of Vulnerability to Age-Dependent Stress and Tau Accumulation

Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice

Sustained translational repression by eIF2α-P mediates prion neurodegeneration

Dysfunction and recovery of synapses in prion disease: implications for neurodegeneration

The Chaperone Grp78 in Protein Folding Disorders of the Nervous System

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration

Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice

Molecular Mechanisms of Chronic Wasting Disease Prion Propagation

Suppression of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Nitric-Oxide Synthase 2 Expression in Astrocytes by a Novel Diindolylmethane Analog Protects Striatal Neurons against Apoptosis

Insights into Mechanisms of Transmission and Pathogenesis from Transgenic Mouse Models of Prion Diseases

Targeted-Neuroinflammation Mitigation Using Inflammasome-Inhibiting Nanoligomers is Therapeutic in an Experimental Autoimmune Encephalomyelitis Mouse Model

Tissue-specific biochemical differences between chronic wasting disease prions isolated from free-ranging white-tailed deer (Odocoileus virginianus)

Compensatory Expression of Nur77 and Nurr1 Regulates NF- κ B-Dependent Inflammatory Signaling in Astrocytes

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