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Pharmacologic Profile of the Dihydropyrimidine Calcium Channel Blockers SQ 32,547 and SQ 32,946

Journal of cardiovascular pharmacology, 1995-08, Vol.26 (2), p.289-294

1995

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Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents

Journal of medicinal chemistry, 1992-08, Vol.35 (17), p.3254-3263

1992

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Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents

Journal of medicinal chemistry, 1991-02, Vol.34 (2), p.806-811

1991

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Discovery of N-Isoxazolyl Biphenylsulfonamides as Potent Dual Angiotensin II and Endothelin A Receptor Antagonists

Journal of medicinal chemistry, 2002-08, Vol.45 (18), p.3829-3835

2002

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The Discovery of Sulfonamide Endothelin Antagonists and the Development of the Orally Active ETA Antagonist 5-(Dimethylamino)-N-(3,4-dimethyl-5- isoxazolyl)-1-naphthalenesulfonamide

Journal of medicinal chemistry, 1994-02, Vol.37 (3), p.329-331

1994

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Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines

Journal of medicinal chemistry, 1990-05, Vol.33 (5), p.1510-1515

1990

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Antihypertensive Effects of a Novel Endothelin - A Receptor Antagonist in Rats

Hypertension (Dallas, Tex. 1979), 1995-06, Vol.25 (6), p.1191-1195

1995

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Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships

Journal of medicinal chemistry, 1993-08, Vol.36 (16), p.2335-2342

1993

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The effects of endothelin-A receptor blockade during the progression of pacing-induced congestive heart failure

Journal of the American College of Cardiology, 1998-11, Vol.32 (6), p.1779-1786

1998

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Regulation of vascular smooth muscle contraction: myosin light chain phosphorylation dependent and independent pathways

Canadian journal of physiology and pharmacology, 1994-11, Vol.72 (11), p.1386

1994

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Orally Active Endothelin Receptor Antagonist BMS-182874 Suppresses Neointimal Development in Balloon-Injured Rat Carotid Arteries

Journal of cardiovascular pharmacology, 1995-12, Vol.26 (6), p.908-915

1995

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Calcium Entry Blockers and Activators: Conformational and Structural Determinants of Dihydropyrimidine Calcium Channel Modulators

Journal of medicinal chemistry, 1995-01, Vol.38 (1), p.119-129

1995

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Studies directed toward ascertaining the active conformation of 1,4-dihydropyridine calcium entry blockers

Journal of medicinal chemistry, 1988-05, Vol.31 (5), p.936-944

1988

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Venous smooth muscle contains vasoconstrictor ETB-like receptors

Biochemical and biophysical research communications, 1992-04, Vol.184 (1), p.100-106

1992

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Effects of Neutral Endopeptidase Inhibition on the Clearance of Exogenously Administered Endothelin in Sprague-Dawley Rats

Journal of cardiovascular pharmacology, 1993-04, Vol.21 (4), p.633-636

1993

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Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists

Journal of medicinal chemistry, 2000-08, Vol.43 (16), p.3111-3117

2000

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Active conformation of 1,4-dihydropyridine calcium entry blockers. Effect of size of 2-aryl substituent on rotameric equilibria and receptor binding

Journal of medicinal chemistry, 1991-08, Vol.34 (8), p.2521-2524

1991

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Biphenylsulfonamide Endothelin Receptor Antagonists. 2. Discovery of 4‘-Oxazolyl Biphenylsulfonamides as a New Class of Potent, Highly Selective ETA Antagonists

Journal of medicinal chemistry, 2000-08, Vol.43 (16), p.3111-3117

2000

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Endothelin receptor antagonists: a brief review

Canadian journal of physiology and pharmacology, 1994-11, Vol.72 (11), p.1469

Moreland, S

1994

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Evidence for a differential location of vasoconstrictor endothelin receptors in the vasculature

British journal of pharmacology, 1994-06, Vol.112 (2), p.704-708

1994

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Functional role of endothelin ETA and ETB receptors in venous and arterial smooth muscle

European journal of pharmacology, 1995-12, Vol.287 (3), p.279-285

1995

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Endothelin-1 and angiotensin-II stimulate delayed mitogenesis in cultured rat aortic smooth muscle cells : evidence for common signaling mechanisms

Molecular endocrinology (Baltimore, Md.), 1994-02, Vol.8 (2), p.148-158

1994

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Dihydropyrimidine calcium channel blockers 51: bicyclic dihydropyrimidines as potent mimics of dihydropyridines

Bioorganic & medicinal chemistry letters, 1991-01, Vol.1 (6), p.291-294

1991

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Cardioselective anti-ischemic ATP-sensitive potassium channel openers

Journal of medicinal chemistry, 1993-11, Vol.36 (24), p.3971-3974

1993

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Pharmacologic Profile of the Dihydropyrimidine Calcium Channel Blockers SQ 32,547 and SQ 32,946

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents

Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents

Discovery of N-Isoxazolyl Biphenylsulfonamides as Potent Dual Angiotensin II and Endothelin A Receptor Antagonists

The Discovery of Sulfonamide Endothelin Antagonists and the Development of the Orally Active ETA Antagonist 5-(Dimethylamino)-N-(3,4-dimethyl-5- isoxazolyl)-1-naphthalenesulfonamide

Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines

Antihypertensive Effects of a Novel Endothelin - A Receptor Antagonist in Rats

Quinoxaline N-oxide containing potent angiotensin II receptor antagonists: synthesis, biological properties, and structure-activity relationships

The effects of endothelin-A receptor blockade during the progression of pacing-induced congestive heart failure

Regulation of vascular smooth muscle contraction: myosin light chain phosphorylation dependent and independent pathways

Orally Active Endothelin Receptor Antagonist BMS-182874 Suppresses Neointimal Development in Balloon-Injured Rat Carotid Arteries

Calcium Entry Blockers and Activators: Conformational and Structural Determinants of Dihydropyrimidine Calcium Channel Modulators

Biphenylsulfonamide Endothelin Receptor Antagonists. 4. Discovery of N-[[2‘-[[(4,5-Dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1‘-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), A Highly Potent and Orally Active ETA Selective Antagonist

Studies directed toward ascertaining the active conformation of 1,4-dihydropyridine calcium entry blockers

Venous smooth muscle contains vasoconstrictor ETB-like receptors

Effects of Neutral Endopeptidase Inhibition on the Clearance of Exogenously Administered Endothelin in Sprague-Dawley Rats

Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists

Active conformation of 1,4-dihydropyridine calcium entry blockers. Effect of size of 2-aryl substituent on rotameric equilibria and receptor binding

Biphenylsulfonamide Endothelin Receptor Antagonists. 2. Discovery of 4‘-Oxazolyl Biphenylsulfonamides as a New Class of Potent, Highly Selective ETA Antagonists

Endothelin receptor antagonists: a brief review

Evidence for a differential location of vasoconstrictor endothelin receptors in the vasculature

Functional role of endothelin ETA and ETB receptors in venous and arterial smooth muscle

Endothelin-1 and angiotensin-II stimulate delayed mitogenesis in cultured rat aortic smooth muscle cells : evidence for common signaling mechanisms

Dihydropyrimidine calcium channel blockers 51: bicyclic dihydropyrimidines as potent mimics of dihydropyridines

Cardioselective anti-ischemic ATP-sensitive potassium channel openers

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