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Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin

Journal of lipid research, 1997-02, Vol.38 (2), p.373-390

1997

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A possible role for plasmalogens in protecting animal cells against photosensitized killing

The Journal of biological chemistry, 1988-08, Vol.263 (23), p.11590-11596

1988

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Disappearance of plasmalogens from membranes of animal cells subjected to photosensitized oxidation

The Journal of biological chemistry, 1988-08, Vol.263 (23), p.11597-11606

1988

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Enhanced Synthesis of the Oxysterol 24(S),25-Epoxycholesterol in Macrophages by Inhibitors of 2,3-Oxidosqualene:Lanosterol Cyclase: A Novel Mechanism for the Attenuation of Foam Cell Formation

Circulation research, 2003-10, Vol.93 (8), p.717-725

2003

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Decrease in scavenger receptor expression in human monocyte-derived macrophages treated with granulocyte macrophage colony-stimulating factor

Arteriosclerosis, thrombosis, and vascular biology, 1996-01, Vol.16 (1), p.106

1996

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A rapid selection for animal cell mutants with defective peroxisomes

Biochimica et biophysica acta, 1990-05, Vol.1034 (2), p.132-141

1990

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Cytoplasmic Requirement for Peroxisome Biogenesis in Chinese Hamster Ovary Cells

Proceedings of the National Academy of Sciences - PNAS, 1989-09, Vol.86 (18), p.7012-7016

1989

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A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content

Arteriosclerosis, thrombosis, and vascular biology, 2005-12, Vol.25 (12), p.2608

2005

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Effects of chronic aortic coarctation on atherosclerosis and arterial lipid accumulation in the Watanabe hereditary hyperlipidemic (WHHL) rabbit

Atherosclerosis, 1992-03, Vol.93 (1), p.123-132

1992

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Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in Syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4′-(6-allyl-ethyl-amino-hexyloxy)-2′-fluoro-phenyl]-(4-bromophenyl)-methanone (Ro 48–8071): comparison to simvastatin

Biochemical pharmacology, 1998-08, Vol.56 (4), p.439-449

1998

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[61] Reactivity of plasmalogens to singlet oxygen and radicals

Methods in Enzymology, 1994, Vol.234, p.603-620

Morand, Olivier H.

1994

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Sphingomyelin Synthase and PKC Activation

Science (American Association for the Advancement of Science), 1989-11, Vol.246 (4933), p.1050-1050

1989

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Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors

Journal of medicinal chemistry, 2003-07, Vol.46 (15), p.3354-3370

2003

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The monotopic membrane protein human oxidosqualene cyclase is active as monomer

Biochemical and biophysical research communications, 2004-03, Vol.315 (2), p.247-254

2004

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Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene−Hopene Cyclase

Journal of medicinal chemistry, 2003-05, Vol.46 (11), p.2083-2092

2003

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Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4'-(6-allyl-ethyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromophenyl)-me thanone (Ro 48-8071): comparison to simvastatin

Biochemical pharmacology, 1998-08, Vol.56 (4), p.439-449

1998

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Human monocyte-derived macrophages express an approximately 120-kD Ox-LDL binding protein with strong identity to CD68

Arteriosclerosis, thrombosis, and vascular biology, 1997-11, Vol.17 (11), p.3107

1997

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Spingomyelin synthase and PKC activation. Response

Science (American Association for the Advancement of Science), 1989, Vol.246 (4933), p.1050-1051

1989

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Trial of Anifrolumab in Active Systemic Lupus Erythematosus

The New England journal of medicine, 2020-01, Vol.382 (3), p.211-221

2020

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A rapid selection for animal cell mutants with defective peroxisomes

Biochimica et biophysica acta, Protein structure and molecular enzymology, 1990-01, Vol.1034 (2), p.132-141

1990

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Cytokines during periodontal wound healing: potential application for new therapeutic approach

Oral diseases, 2017-04, Vol.23 (3), p.300-311

2017

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Progress on the calibration of surface brightness–color relations for early- and late-type stars

Astronomy and astrophysics (Berlin), 2021-08, Vol.652, p.A26

2021

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Factors associated with the emergence of integrase resistance mutations in patients failing dual or triple integrase inhibitor-based regimens in a French national survey

Journal of antimicrobial chemotherapy, 2021-09, Vol.76 (9), p.2400-2406

2021

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OMERACT 2023 Systemic Lupus Erythematosus Special Interest Group: Winnowing and Binning Preliminary Candidate Domains for the Core Outcome Set

Seminars in arthritis and rheumatism, 2024-04, Vol.65, p.152380, Article 152380

2024

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Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin

A possible role for plasmalogens in protecting animal cells against photosensitized killing

Disappearance of plasmalogens from membranes of animal cells subjected to photosensitized oxidation

Enhanced Synthesis of the Oxysterol 24(S),25-Epoxycholesterol in Macrophages by Inhibitors of 2,3-Oxidosqualene:Lanosterol Cyclase: A Novel Mechanism for the Attenuation of Foam Cell Formation

Decrease in scavenger receptor expression in human monocyte-derived macrophages treated with granulocyte macrophage colony-stimulating factor

A rapid selection for animal cell mutants with defective peroxisomes

Cytoplasmic Requirement for Peroxisome Biogenesis in Chinese Hamster Ovary Cells

A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content

Effects of chronic aortic coarctation on atherosclerosis and arterial lipid accumulation in the Watanabe hereditary hyperlipidemic (WHHL) rabbit

Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in Syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4′-(6-allyl-ethyl-amino-hexyloxy)-2′-fluoro-phenyl]-(4-bromophenyl)-methanone (Ro 48–8071): comparison to simvastatin

[61] Reactivity of plasmalogens to singlet oxygen and radicals

Sphingomyelin Synthase and PKC Activation

Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors

The monotopic membrane protein human oxidosqualene cyclase is active as monomer

Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene−Hopene Cyclase

Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4'-(6-allyl-ethyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromophenyl)-me thanone (Ro 48-8071): comparison to simvastatin

Human monocyte-derived macrophages express an approximately 120-kD Ox-LDL binding protein with strong identity to CD68

Spingomyelin synthase and PKC activation. Response

Trial of Anifrolumab in Active Systemic Lupus Erythematosus

A rapid selection for animal cell mutants with defective peroxisomes

Cytokines during periodontal wound healing: potential application for new therapeutic approach

Progress on the calibration of surface brightness–color relations for early- and late-type stars

Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

Factors associated with the emergence of integrase resistance mutations in patients failing dual or triple integrase inhibitor-based regimens in a French national survey

OMERACT 2023 Systemic Lupus Erythematosus Special Interest Group: Winnowing and Binning Preliminary Candidate Domains for the Core Outcome Set

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