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Discovery of pyrrolopyrimidine inhibitors of Akt

Bioorganic & medicinal chemistry letters, 2010-10, Vol.20 (19), p.5607-5612

2010

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Discovery and SAR of spirochromane Akt inhibitors

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2410-2414

2011

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Preclinical characterization of pirtobrutinib, a highly selective, noncovalent (reversible) BTK inhibitor

Blood, 2023-07, Vol.142 (1), p.62-72

2023

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An ATP-site on-off switch that restricts phosphatase accessibility of Akt

Science signaling, 2012-05, Vol.5 (223), p.ra37

2012

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Cloning and preliminary characterization of a novel cuticular antigen from the filarial parasite Dirofilaria immitis

Parasitology international, 2000-12, Vol.49 (4), p.321-325

2000

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The formation of mitochondrial ribonucleoprotein complexes involving guide RNA molecules in Trypanosoma brucei

Proceedings of the National Academy of Sciences - PNAS, 1994-03, Vol.91 (5), p.1776-1780

1994

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Abstract 2780: Unique pharmacodynamic properties conferred by differential binding to BTK, pirtobrutinib vs covalent inhibitors

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.2780-2780

2023

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Identification of an asparagine amidohydrolase from the filarial parasite Dirofilaria immitis

International journal for parasitology, 1999-09, Vol.29 (9), p.1451-1455

1999

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An Abnormal Pattern of Embryonic Development during Early Pregnancy in Aging Rats1

Biology of reproduction, 1989-11, Vol.41 (5), p.933-939

1989

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Molecular characterization of a calcium-binding protein from the filarial parasite Dirofilaria immitis

Molecular and biochemical parasitology, 1998-11, Vol.97 (1), p.69-79

1998

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In vitro guide RNA/mRNA chimaera formation in Trypanosoma bruceiRNA editing

Nature (London), 1992-04, Vol.356 (6372), p.807-809

1992

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Identification of an asparagine amidohydrolase from the filarial parasite Dirofilaria immitis1The nucleotide sequence reported in this paper has been submitted to the GenBank database with accession number AF116552.1

International journal for parasitology, 1999-09, Vol.29 (9), p.1451-1455

1999

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Structural organization of the maxicircle variable region of Trypanosoma brucei: identification of potential replication origins and topoisomerase II binding sites

Nucleic acids research, 1993-02, Vol.21 (3), p.687-694

1993

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Genomic and transcriptional linkage of the genes for calmodulin, EF-hand 5 protein, and ubiquitin extension protein 52 in Trypanosoma brucei

Molecular and Cellular Biology, 1993-01, Vol.13 (1), p.207-216

1993

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In vitro guide RNA/mRNA chimaera formation in Trypanosoma brucei RNA editing

Nature (London), 1992-04, Vol.356 (6372), p.807-809

1992

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Male Stimulation of Luteinizing Hormone Surge, Progesterone SeCretion and Ovulation in Spontaneously Persistent-Estrous, Aging Rats1

Biology of reproduction, 1988-06, Vol.38 (5), p.1019-1026

1988

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Genomic and Transcriptional Linkage of the Genes for Calmodulin, EF-Hand 5 Protein, and Ubiquitin Extension Protein 52 in Trypanosoma brucei

Molecular and cellular biology, 1993-01, Vol.13 (1), p.207-216

1993

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A standardized framework for representation of ancestry data in genomics studies, with application to the NHGRI-EBI GWAS Catalog

Genome Biology, 2018-02, Vol.19 (1), p.21-21, Article 21

2018

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Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial

Fertility and sterility, 2019-12, Vol.112 (6), p.1071-1079.e7

2019

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Drotrecogin Alfa (Activated) in Adults with Septic Shock

The New England journal of medicine, 2012-05, Vol.366 (22), p.2055-2064

2012

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The development of cephalic armor in the tokay gecko (Squamata: Gekkonidae: Gekko gecko)

Journal of morphology (1931), 2020-02, Vol.281 (2), p.213-228

2020

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Risk Factors for Ebola Virus Persistence in Semen of Survivors in Liberia

Clinical infectious diseases, 2023-02, Vol.76 (3), p.e849-e856

2023

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Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial

Journal of clinical oncology, 2022-08, Vol.40 (22), p.2479-2490

2022

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A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors

Discovery of pyrrolopyrimidine inhibitors of Akt

Discovery and SAR of spirochromane Akt inhibitors

Preclinical characterization of pirtobrutinib, a highly selective, noncovalent (reversible) BTK inhibitor

An ATP-site on-off switch that restricts phosphatase accessibility of Akt

Cloning and preliminary characterization of a novel cuticular antigen from the filarial parasite Dirofilaria immitis

Pirtobrutinib preclinical characterization: a highly selective, non-covalent (reversible) BTK inhibitor

The formation of mitochondrial ribonucleoprotein complexes involving guide RNA molecules in Trypanosoma brucei

Abstract 2780: Unique pharmacodynamic properties conferred by differential binding to BTK, pirtobrutinib vs covalent inhibitors

Identification of an asparagine amidohydrolase from the filarial parasite Dirofilaria immitis

An Abnormal Pattern of Embryonic Development during Early Pregnancy in Aging Rats1

Molecular characterization of a calcium-binding protein from the filarial parasite Dirofilaria immitis

In vitro guide RNA/mRNA chimaera formation in Trypanosoma bruceiRNA editing

Identification of an asparagine amidohydrolase from the filarial parasite Dirofilaria immitis1The nucleotide sequence reported in this paper has been submitted to the GenBank database with accession number AF116552.1

Structural organization of the maxicircle variable region of Trypanosoma brucei: identification of potential replication origins and topoisomerase II binding sites

Genomic and transcriptional linkage of the genes for calmodulin, EF-hand 5 protein, and ubiquitin extension protein 52 in Trypanosoma brucei

In vitro guide RNA/mRNA chimaera formation in Trypanosoma brucei RNA editing

Male Stimulation of Luteinizing Hormone Surge, Progesterone SeCretion and Ovulation in Spontaneously Persistent-Estrous, Aging Rats1

Genomic and Transcriptional Linkage of the Genes for Calmodulin, EF-Hand 5 Protein, and Ubiquitin Extension Protein 52 in Trypanosoma brucei

A standardized framework for representation of ancestry data in genomics studies, with application to the NHGRI-EBI GWAS Catalog

Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial

Drotrecogin Alfa (Activated) in Adults with Septic Shock

The development of cephalic armor in the tokay gecko (Squamata: Gekkonidae: Gekko gecko)

Risk Factors for Ebola Virus Persistence in Semen of Survivors in Liberia

Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial

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