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Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: A new use of silicon bioisosteres in medicinal chemistry

Bioorganic & medicinal chemistry letters, 2007-01, Vol.17 (2), p.354-357

2007

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Update on the therapeutic potential of PDE4 inhibitors

Expert opinion on investigational drugs, 2002-01, Vol.11 (1), p.1-13

2002

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Sila-venlafaxine, a Sila-Analogue of the Serotonin/Noradrenaline Reuptake Inhibitor Venlafaxine: Synthesis, Crystal Structure Analysis, and Pharmacological Characterization

Organometallics, 2006-02, Vol.25 (5), p.1188-1198

2006

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Synthesis, Crystal Structure Analysis, and Pharmacological Characterization of Disila-bexarotene, a Disila-Analogue of the RXR-Selective Retinoid Agonist Bexarotene

Organometallics, 2005-06, Vol.24 (13), p.3192-3199

2005

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( R)-Sila-venlafaxine: A selective noradrenaline reuptake inhibitor for the treatment of emesis

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2555-2558

2006

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Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors

Bioorganic & medicinal chemistry letters, 2001-06, Vol.11 (11), p.1465-1468

2001

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Silicon Analogues of the Nonpeptidic GnRH Antagonist AG-045572: Syntheses, Crystal Structure Analyses, and Pharmacological Characterization

ChemMedChem, 2011-11, Vol.6 (11), p.2070-2080

2011

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Action of ( R)-sila-venlafaxine and reboxetine to antagonize cisplatin-induced acute and delayed emesis in the ferret

Toxicology and applied pharmacology, 2008-11, Vol.232 (3), p.369-375

2008

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Estimation of pKa Using Semiempirical Molecular Orbital Methods. Part 1: Application to Phenols and Carboxylic Acids

Quantitative structure-activity relationships, 2002-11, Vol.21 (5), p.457-472

2002

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Synthesis and structure–activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors

Bioorganic & medicinal chemistry letters, 2001-04, Vol.11 (8), p.1081-1083

2001

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Selecting Screening Candidates for Kinase and G Protein-Coupled Receptor Targets Using Neural Networks

Journal of Chemical Information and Computer Sciences, 2002-09, Vol.42 (5), p.1256-1262

2002

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8-Methoxyquinolines as PDE4 inhibitors

Bioorganic & medicinal chemistry letters, 2002-06, Vol.12 (12), p.1617-1619

2002

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7-Methoxyfuro[2,3- c]pyridine-4-carboxamides as PDE4 Inhibitors: A Potential Treatment for Asthma

Bioorganic & medicinal chemistry letters, 2002-02, Vol.12 (3), p.509-512

2002

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8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma

Bioorganic & medicinal chemistry letters, 2002-06, Vol.12 (12), p.1613-1615

2002

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7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma

Bioorganic & medicinal chemistry letters, 2000-09, Vol.10 (18), p.2137-2140

2000

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Aryl sulfonamides as selective PDE4 inhibitors

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2635-2640

1998

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PDE4 inhibitors: New xanthine analogues

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (20), p.2925-2930

1998

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Use of polymer supported thiophenol for the synthesis and purification of a benzimidazol-2-one library

Tetrahedron letters, 2000-04, Vol.41 (14), p.2483-2485

2000

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Mercaptoacyl matrix metalloproteinase inhibitors: The effect of substitution at the mercaptoacyl moiety

Bioorganic & medicinal chemistry letters, 1997-11, Vol.7 (21), p.2765-2770

1997

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Synthesis of trans-fused [5,5] bicyclic lactones/lactams as templates for serine protease inhibition

Tetrahedron letters, 1998-09, Vol.39 (38), p.6979-6982

1998

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Synthesis of (+/-)-Oxohexahydrofuro[3,2-b]pyrroles (Pyrrolidine-trans-lactones) via a Reduction-Alkylation Protocol

Synlett, 1998-12, Vol.1998 (12), p.1378-1380

1998

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Theoretical hydrogen bonding parameters for drug design

Journal of molecular graphics & modelling, 2001-01, Vol.19 (3), p.349-362

2001

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The therapeutic potential of PDE4 inhibitors

Expert opinion on investigational drugs, 1999-09, Vol.8 (9), p.1301-1325

1999

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Synthesis, crystal structure analysis, and pharmacological characterization of desmethoxy-sila-venlafaxine, a derivative of the serotonin/noradrenaline reuptake inhibitor sila-venlafaxine

Journal of organometallic chemistry, 2006-08, Vol.691 (17), p.3589-3595

2006

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Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (19), p.2629-2634

1998

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Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: A new use of silicon bioisosteres in medicinal chemistry

Update on the therapeutic potential of PDE4 inhibitors

Sila-venlafaxine, a Sila-Analogue of the Serotonin/Noradrenaline Reuptake Inhibitor Venlafaxine: Synthesis, Crystal Structure Analysis, and Pharmacological Characterization

Synthesis, Crystal Structure Analysis, and Pharmacological Characterization of Disila-bexarotene, a Disila-Analogue of the RXR-Selective Retinoid Agonist Bexarotene

( R)-Sila-venlafaxine: A selective noradrenaline reuptake inhibitor for the treatment of emesis

Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors

Silicon Analogues of the Nonpeptidic GnRH Antagonist AG-045572: Syntheses, Crystal Structure Analyses, and Pharmacological Characterization

Action of ( R)-sila-venlafaxine and reboxetine to antagonize cisplatin-induced acute and delayed emesis in the ferret

Estimation of pKa Using Semiempirical Molecular Orbital Methods. Part 1: Application to Phenols and Carboxylic Acids

Synthesis and structure–activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors

Selecting Screening Candidates for Kinase and G Protein-Coupled Receptor Targets Using Neural Networks

8-Methoxyquinolines as PDE4 inhibitors

7-Methoxyfuro[2,3- c]pyridine-4-carboxamides as PDE4 Inhibitors: A Potential Treatment for Asthma

8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma

7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma

Aryl sulfonamides as selective PDE4 inhibitors

PDE4 inhibitors: New xanthine analogues

Use of polymer supported thiophenol for the synthesis and purification of a benzimidazol-2-one library

Mercaptoacyl matrix metalloproteinase inhibitors: The effect of substitution at the mercaptoacyl moiety

Synthesis of trans-fused [5,5] bicyclic lactones/lactams as templates for serine protease inhibition

Synthesis of (+/-)-Oxohexahydrofuro[3,2-b]pyrroles (Pyrrolidine-trans-lactones) via a Reduction-Alkylation Protocol

Theoretical hydrogen bonding parameters for drug design

The therapeutic potential of PDE4 inhibitors

Synthesis, crystal structure analysis, and pharmacological characterization of desmethoxy-sila-venlafaxine, a derivative of the serotonin/noradrenaline reuptake inhibitor sila-venlafaxine

Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma

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