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Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

Nature communications, 2019-11, Vol.10 (1), p.5167-19, Article 5167

2019

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Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells

Molecular cancer therapeutics, 2007-02, Vol.6 (2), p.587-598

2007

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Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue

Journal of translational medicine, 2012-06, Vol.10 (1), p.125-125, Article 125

2012

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Anoikis-resistant subpopulations of human osteosarcoma display significant chemoresistance and are sensitive to targeted epigenetic therapies predicted by expression profiling

Journal of translational medicine, 2015-04, Vol.13 (1), p.110-110, Article 110

2015

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Oncolytic VSV Primes Differential Responses to Immuno-oncology Therapy

Molecular therapy, 2017-08, Vol.25 (8), p.1917-1932

2017

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Sensitivity of breast cancer cell lines to recombinant thiaminase I

Cancer chemotherapy and pharmacology, 2010-05, Vol.66 (1), p.171-179

2010

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Characterization of the anti‐CD22 targeted therapy, moxetumomab pasudotox, for B‐cell precursor acute lymphoblastic leukemia

Pediatric blood & cancer, 2017-11, Vol.64 (11), p.n/a

2017

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Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil

Journal of experimental marine biology and ecology, 2002-12, Vol.281 (1), p.1-12

2002

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Mediation of antitumor activity by AZD4820 oncolytic vaccinia virus encoding IL-12

Molecular Therapy: Oncology, 2024-03, Vol.32 (1), p.200758, Article 200758

2024

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Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors

Journal of translational medicine, 2013-09, Vol.11 (1), p.213-213, Article 213

2013

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Melanoma genotypes and phenotypes get personal

Laboratory investigation, 2013-08, Vol.93 (8), p.858-867

2013

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Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition

Toxicon (Oxford), 2010-04, Vol.55 (4), p.827-837

2010

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Using a rhabdomyosarcoma patient‐derived xenograft to examine precision medicine approaches and model acquired resistance

Pediatric blood & cancer, 2014-09, Vol.61 (9), p.1570-1577

2014

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A multi-site feasibility study for personalized medicine in canines with osteosarcoma

Journal of translational medicine, 2013-07, Vol.11 (1), p.158-158, Article 158

2013

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Addressing the design of in vitro models for the investigation of microcystins: The essential role of transporter-mediated uptake

Cell biology international, 2010-09, Vol.34 (9), p.907-909

2010

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Melanoma patient derived xenografts acquire distinct Vemurafenib resistance mechanisms

American journal of cancer research, 2015-01, Vol.5 (4), p.1507-1518

2015

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Targeting the NF-κB pathway in estrogen receptor negative MDA-MB-231 breast cancer cells using small inhibitory RNAs

Journal of cellular biochemistry, 2006-05, Vol.98 (1), p.221-233

2006

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I06 Allele-selective inhibition of mutant htt transcription throughout the brain after subcutaneous administration of a patrol™-enabled investigational genetic therapy in the r6/2 Huntington’s disease transgenic mouse model

Journal of neurology, neurosurgery and psychiatry, 2022-09, Vol.93 (Suppl 1), p.A86-A87

2022

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DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767

European journal of cancer (1990), 2002-07, Vol.38 (11), p.1543-1552

2002

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Abstract LB-298: MEDI7247: A first in class antibody drug conjugate targeting ASCT2 in a range of solid tumors

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.LB-298-LB-298

2018

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Abstract LB-296: Discovery and development of MEDI7247, a novel Pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2, for treating hematological and solid cancers

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.LB-296-LB-296

2018

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Abstract LB-295: MEDI7247, a novel pyrrolobenzodiazepine ADC targeting ASCT2 with potent in vivo activity across a spectrum of hematological malignancies

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.LB-295-LB-295

2018

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Discovery and Development of MEDI7247, a Novel Pyrrolobenzodiazepine (PBD)-Based Antibody Drug Conjugate Targeting ASCT2, for Treating Hematological Cancers

Blood, 2018-11, Vol.132 (Supplement 1), p.4071-4071

2018

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In vitro Cytotoxicity of Extracts from Brazilian Asteraceae

Pharmaceutical biology, 2002-10, Vol.40 (7), p.494-500

2002

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Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells

Genomic characterization of explant tumorgraft models derived from fresh patient tumor tissue

Anoikis-resistant subpopulations of human osteosarcoma display significant chemoresistance and are sensitive to targeted epigenetic therapies predicted by expression profiling

Oncolytic VSV Primes Differential Responses to Immuno-oncology Therapy

Sensitivity of breast cancer cell lines to recombinant thiaminase I

Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer

Characterization of the anti‐CD22 targeted therapy, moxetumomab pasudotox, for B‐cell precursor acute lymphoblastic leukemia

Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil

Mediation of antitumor activity by AZD4820 oncolytic vaccinia virus encoding IL-12

Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors

Melanoma genotypes and phenotypes get personal

Abrogation of microcystin cytotoxicity by MAP kinase inhibitors and N-acetyl cysteine is confounded by OATPIB1 uptake activity inhibition

Using a rhabdomyosarcoma patient‐derived xenograft to examine precision medicine approaches and model acquired resistance

A multi-site feasibility study for personalized medicine in canines with osteosarcoma

Addressing the design of in vitro models for the investigation of microcystins: The essential role of transporter-mediated uptake

Melanoma patient derived xenografts acquire distinct Vemurafenib resistance mechanisms

Targeting the NF-κB pathway in estrogen receptor negative MDA-MB-231 breast cancer cells using small inhibitory RNAs

I06 Allele-selective inhibition of mutant htt transcription throughout the brain after subcutaneous administration of a patrol™-enabled investigational genetic therapy in the r6/2 Huntington’s disease transgenic mouse model

DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767

Abstract LB-298: MEDI7247: A first in class antibody drug conjugate targeting ASCT2 in a range of solid tumors

Abstract LB-296: Discovery and development of MEDI7247, a novel Pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2, for treating hematological and solid cancers

Abstract LB-295: MEDI7247, a novel pyrrolobenzodiazepine ADC targeting ASCT2 with potent in vivo activity across a spectrum of hematological malignancies

Discovery and Development of MEDI7247, a Novel Pyrrolobenzodiazepine (PBD)-Based Antibody Drug Conjugate Targeting ASCT2, for Treating Hematological Cancers

In vitro Cytotoxicity of Extracts from Brazilian Asteraceae

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