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Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

Cancer cell, 2019-11, Vol.36 (5), p.545-558.e7

2019

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4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activities

Current topics in medicinal chemistry, 2014-01, Vol.14 (14), p.1693-1705

2014

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4(1H)-Quinolones with Liver Stage Activity against Plasmodium berghei

Antimicrobial Agents and Chemotherapy, 2013-01, Vol.57 (1), p.417-424

2013

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The promise and current status of CDK12/13 inhibition for the treatment of cancer

Future medicinal chemistry, 2021-01, Vol.13 (2), p.117-141

2021

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Enantio‐ and Diastereoselective (Ipc) 2 BOTf‐Mediated Aldol Reactions of Morpholine Carboxamides

Helvetica chimica acta, 2023-12, Vol.106 (12)

2023

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Metal-Free Arylation of Ethyl Acetoacetate with Hypervalent Diaryliodonium Salts: An Immediate Access to Diverse 3‑Aryl-4(1H)‑Quinolones

Journal of organic chemistry, 2015-03, Vol.80 (5), p.2513-2520

2015

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Structure-independent machine-learning predictions of the CDK12 interactome

Biophysical journal, 2024-09, Vol.123 (17), p.2910-2920

2024

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Abstract 950: New strategy to sensitize pancreatic and bladder cancer to gemcitabine

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.950-950

2018

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Enantio‐ and Diastereoselective (Ipc)2BOTf‐Mediated Aldol Reactions of Morpholine Carboxamides

Helvetica chimica acta, 2023-12, Vol.106 (12), p.n/a

2023

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Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer

Bioorganic & medicinal chemistry, 2018-02, Vol.26 (3), p.590-602

2018

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Scalable Multigram Syntheses of Antimalarial 4(1H)‐Quinolones ELQ‐300 and P4Q‐391

European journal of organic chemistry, 2017-06, Vol.2017 (23), p.3328-3334

2017

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Abstract B064: Therapeutic potential of CK1 delta inhibition in pancreatic and bladder cancer

Molecular cancer therapeutics, 2018-01, Vol.17 (1_Supplement), p.B064-B064

2018

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The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation

The Journal of biological chemistry, 2024-01, Vol.300 (1), p.105501-105501, Article 105501

2024

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Abstract 3051: Targeting cdk12/13 re-sensitizes trastuzumab resistant her2+ breast cancers

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3051-3051

2019

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Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties

European journal of medicinal chemistry, 2024-02, Vol.266, p.116101-116101, Article 116101

2024

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Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (3), p.400-404

2018

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Going beyond Binary: Rapid Identification of Protein–Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach

Journal of medicinal chemistry, 2023-04, Vol.66 (7), p.5196-5207

2023

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Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2

Cell chemical biology, 2024-02, Vol.31 (2), p.284-297.e10

2024

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Engaging the Medicinal Chemists of Tomorrow

Journal of medicinal chemistry, 2022-05, Vol.65 (9), p.6353-6355

2022

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Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase

Molecular cancer therapeutics, 2020-08, Vol.19 (8), p.1623-1635

2020

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Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)‑Quinolones with Potent Antimalarial Activity: Structure–Activity and Structure–Property Relationship Studies

Journal of medicinal chemistry, 2018-02, Vol.61 (4), p.1450-1473

2018

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Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)‑Quinolones with Single Dose Cures

Journal of medicinal chemistry, 2021-05, Vol.64 (10), p.6581-6595

2021

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CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma

Cancer research (Chicago, Ill.), 2023-12, Vol.83 (23), p.3901-3919

2023

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Endochin Optimization: Structure−Activity and Structure−Property Relationship Studies of 3-Substituted 2-Methyl-4(1H)-quinolones with Antimalarial Activity

Journal of medicinal chemistry, 2010-10, Vol.53 (19), p.7076-7094

2010

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Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target

ACS chemical biology, 2023-02, Vol.18 (2), p.251-264

2023

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Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activities

4(1H)-Quinolones with Liver Stage Activity against Plasmodium berghei

The promise and current status of CDK12/13 inhibition for the treatment of cancer

Enantio‐ and Diastereoselective (Ipc) 2 BOTf‐Mediated Aldol Reactions of Morpholine Carboxamides

Metal-Free Arylation of Ethyl Acetoacetate with Hypervalent Diaryliodonium Salts: An Immediate Access to Diverse 3‑Aryl-4(1H)‑Quinolones

Structure-independent machine-learning predictions of the CDK12 interactome

Abstract 950: New strategy to sensitize pancreatic and bladder cancer to gemcitabine

Enantio‐ and Diastereoselective (Ipc)2BOTf‐Mediated Aldol Reactions of Morpholine Carboxamides

Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer

Scalable Multigram Syntheses of Antimalarial 4(1H)‐Quinolones ELQ‐300 and P4Q‐391

Abstract B064: Therapeutic potential of CK1 delta inhibition in pancreatic and bladder cancer

The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation

Abstract 3051: Targeting cdk12/13 re-sensitizes trastuzumab resistant her2+ breast cancers

Development of potent and selective ULK1/2 inhibitors based on 7-azaindole scaffold with favorable in vivo properties

Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors

Going beyond Binary: Rapid Identification of Protein–Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach

Differential network analysis of ROS1 inhibitors reveals lorlatinib polypharmacology through co-targeting PYK2

Engaging the Medicinal Chemists of Tomorrow

Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase

Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)‑Quinolones with Potent Antimalarial Activity: Structure–Activity and Structure–Property Relationship Studies

Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)‑Quinolones with Single Dose Cures

CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma

Endochin Optimization: Structure−Activity and Structure−Property Relationship Studies of 3-Substituted 2-Methyl-4(1H)-quinolones with Antimalarial Activity

Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target

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