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Crystal structure of the T315I abl mutant in complex with the aurora kinases inhibitor PHA-739358

Cancer research (Chicago, Ill.), 2007-09, Vol.67 (17), p.7987-7990

2007

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Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma

Cancer research (Chicago, Ill.), 2016-11, Vol.76 (21), p.6382-6395

2016

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Spindle Misorientation of Cerebral and Cerebellar Progenitors Is a Mechanistic Cause of Megalencephaly

Stem cell reports, 2017-10, Vol.9 (4), p.1071-1080

2017

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A Phase I Dose-Escalation Study of Danusertib (PHA-739358) Administered as a 24-Hour Infusion with and without Granulocyte Colony-Stimulating Factor in a 14-Day Cycle in Patients with Advanced Solid Tumors

Clinical cancer research, 2009-11, Vol.15 (21), p.6694-6701

2009

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Tumor spheroid-based migration assays for evaluation of therapeutic agents

Methods in molecular biology (Clifton, N.J.), 2013, Vol.986, p.253

2013

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TEAD Inhibitors Sensitize KRASG12C Inhibitors via Dual Cell Cycle Arrest in KRASG12C-Mutant NSCLC

Pharmaceuticals (Basel, Switzerland), 2023-04, Vol.16 (4), p.553

2023

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Destabilizing aneuploidy by targeting cell cycle and mitotic checkpoint proteins in cancer cells

Current drug targets, 2010-10, Vol.11 (10), p.1325

2010

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Aurora Kinase Inhibitor PHA-739358 Suppresses Growth of Hepatocellular Carcinoma In Vitro and in a Xenograft Mouse Model

Neoplasia (New York, N.Y.), 2009-09, Vol.11 (9), p.934-944

2009

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PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer

Molecular cancer therapeutics, 2007-12, Vol.6 (12), p.3158-3168

2007

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4,5-Dihydro-1H-pyrazolo[4,3-h]quinazolines as potent and selective Polo-like kinase 1 (PLK1) inhibitors

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6489-6494

2010

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Combined microRNA in situ hybridization and immunohistochemical detection of protein markers

Methods in molecular biology (Clifton, N.J.), 2013, Vol.986, p.353

2013

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Targeting Cell Division Cycle 7 Kinase: A New Approach for Cancer Therapy

Clinical cancer research, 2010-09, Vol.16 (18), p.4503-4508

2010

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Identification of 4,5-Dihydro-1H-pyrazolo[4,3-h]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors

Journal of medicinal chemistry, 2010-05, Vol.53 (9), p.3532-3551

2010

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Discovery of a novel tumour metastasis-promoting gene, NVM-1

The Journal of pathology, 2011-09, Vol.225 (1), p.96-105

2011

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The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy

Molecular cancer therapeutics, 2017-10, Vol.16 (10), p.2223-2233

2017

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High-content analysis of kinase activity in cells

Combinatorial chemistry & high throughput screening, 2008-08, Vol.11 (7), p.523

2008

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The neurosphere assay applied to neural stem cells and cancer stem cells

Methods in molecular biology (Clifton, N.J.), 2013, Vol.986, p.267

Galli, Rossella

2013

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Western blot evaluation of siRNA delivery by pH-responsive peptides

Methods in molecular biology (Clifton, N.J.), 2013, Vol.986, p.73

2013

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PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity

Clinical cancer research, 2006-07, Vol.12 (13), p.4080-4089

2006

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Miniaturizing bromodeoxyuridine incorporation enables the usage of flow cytometry for cell cycle analysis of adherent tissue culture cells for high throughput screening

Cytometry. Part A, 2010-10, Vol.77A (10), p.953-961

2010

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Kinetics of senescence-associated changes of gene expression in an epithelial, temperature-sensitive SV40 large T antigen model

Cancer research (Chicago, Ill.), 2004-01, Vol.64 (2), p.482-489

2004

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1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazoles: Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.7247-7251

2006

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A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Crystal structure of the T315I abl mutant in complex with the aurora kinases inhibitor PHA-739358

Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma

Spindle Misorientation of Cerebral and Cerebellar Progenitors Is a Mechanistic Cause of Megalencephaly

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

A Phase I Dose-Escalation Study of Danusertib (PHA-739358) Administered as a 24-Hour Infusion with and without Granulocyte Colony-Stimulating Factor in a 14-Day Cycle in Patients with Advanced Solid Tumors

Tumor spheroid-based migration assays for evaluation of therapeutic agents

TEAD Inhibitors Sensitize KRASG12C Inhibitors via Dual Cell Cycle Arrest in KRASG12C-Mutant NSCLC

Destabilizing aneuploidy by targeting cell cycle and mitotic checkpoint proteins in cancer cells

Aurora Kinase Inhibitor PHA-739358 Suppresses Growth of Hepatocellular Carcinoma In Vitro and in a Xenograft Mouse Model

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer

4,5-Dihydro-1H-pyrazolo[4,3-h]quinazolines as potent and selective Polo-like kinase 1 (PLK1) inhibitors

Combined microRNA in situ hybridization and immunohistochemical detection of protein markers

Targeting Cell Division Cycle 7 Kinase: A New Approach for Cancer Therapy

Identification of 4,5-Dihydro-1H-pyrazolo[4,3-h]quinazoline Derivatives as a New Class of Orally and Selective Polo-Like Kinase 1 Inhibitors

Discovery of a novel tumour metastasis-promoting gene, NVM-1

The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy

High-content analysis of kinase activity in cells

The neurosphere assay applied to neural stem cells and cancer stem cells

Western blot evaluation of siRNA delivery by pH-responsive peptides

BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition

PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity

Miniaturizing bromodeoxyuridine incorporation enables the usage of flow cytometry for cell cycle analysis of adherent tissue culture cells for high throughput screening

Kinetics of senescence-associated changes of gene expression in an epithelial, temperature-sensitive SV40 large T antigen model

1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazoles: Identification of a Potent Aurora Kinase Inhibitor with a Favorable Antitumor Kinase Inhibition Profile

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