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Pegylation: Engineering Improved Biopharmaceuticals for Oncology

Pharmacotherapy, 2003-08, Vol.23 (8P2), p.3S-8S

Molineux, Graham

2003

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Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

Blood, 2010-04, Vol.115 (17), p.3616-3624

2010

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A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates

Blood, 2013-10, Vol.122 (17), p.3054-3061

2013

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Mono-N-terminal poly(ethylene glycol)–protein conjugates

Advanced drug delivery reviews, 2002-06, Vol.54 (4), p.477-485

2002

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The development of romiplostim for patients with immune thrombocytopenia

Annals of the New York Academy of Sciences, 2011-03, Vol.1222 (1), p.55-63

Molineux, Graham

2011

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Development of romiplostim for the treatment of patients with chronic immune thrombocytopenia: from bench to bedside

British journal of haematology, 2010-07, Vol.150 (1), p.9-20

2010

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The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta)

Current pharmaceutical design, 2004-04, Vol.10 (11), p.1235

Molineux, G

2004

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Kinetics of Neutrophil Production in Normal and Neutropenic Animals during the Response to Filgrastim (r-metHu G-CSF) or Filgrastim SD/01 (PEG-r-metHu G-CSF)

Clinical cancer research, 2001-07, Vol.7 (7), p.2085-2090

2001

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Pegylation: engineering improved pharmaceuticals for enhanced therapy

Cancer treatment reviews, 2002, Vol.28, p.13-16

Molineux, G.

2002

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Pegfilgrastim: using pegylation technology to improve neutropenia support in cancer patients

Anti-cancer drugs, 2003-04, Vol.14 (4), p.259-264

Molineux, Graham

2003

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Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

Cell metabolism, 2012-06, Vol.15 (6), p.905-917

2012

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Repeated Hematopoietic Stem and Progenitor Cell Mobilization Without Depletion of the Bone Marrow Stem and Progenitor Cell Pool in Mice After Repeated Administration of Recombinant Murine G-CSF

Human immunology, 2007-05, Vol.68 (5), p.368-374

2007

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Granulocyte colony-stimulating factors

Cancer treatment and research, 2011, Vol.157, p.33

Molineux, Graham

2011

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Romiplostim promotes platelet recovery in a mouse model of multicycle chemotherapy-induced thrombocytopenia

Experimental hematology, 2015-06, Vol.43 (6), p.479-487

2015

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Investigation of the effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: Nonerythropoietin receptor-mediated pathways may play a major role

Journal of pharmaceutical sciences, 2009-06, Vol.98 (6), p.2198-2211

2009

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Abstract 4109: Romiplostim promotes platelet recovery in a mouse model of multicycle chemotherapy-induced thrombocytopenia

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.4109-4109

2013

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Comparison of Epoetin Alfa and Darbepoetin Alfa Biological Activity under Different Administration Schedules in Normal Mice

Acta haematologica, 2005-01, Vol.113 (3), p.163-174

2005

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Serum hepcidin but not prohepcidin may be an effective marker for anemia of inflammation (AI)

Blood cells, molecules, & diseases, 2010-10, Vol.45 (3), p.238-245

2010

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Pegylation: Engineering improved biopharmaceuticals for oncology: Pegfilgrastim: A new era in the management of chemotherapy-induced neutropenia

Pharmacotherapy, 2003, Vol.23 (8), p.3S-8S

MOLINEUX, Graham

2003

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Phosphatidylinsoitol-3 Kinase Delta (PI3Kδ) Inhibitor AMG 319 Combined with Vincristine Enhances G2/M Arrest and Apoptotic Death in Neoplastic B Cells

Blood, 2011-11, Vol.118 (21), p.4963-4963

2011

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Physiologic and pathologic consequences of granulocyte colony-stimulating factor deficiency: Hematopoietic growth factors

Current opinion in hematology, 2002, Vol.9 (3), p.199-201

MOLINEUX, Graham

2002

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New Insights on Assessing Intra-Family Selectivity for Jak2 Inhibitors

Blood, 2011-11, Vol.118 (21), p.5150-5150

2011

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Fetal Hemoglobin Expression Is Differentially Affected by Inhibition of the Proposed Dred Complex Constituents, LSD1 and DNMT1

Blood, 2012-11, Vol.120 (21), p.3263-3263

2012

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A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans

Experimental hematology, 1999-12, Vol.27 (12), p.1724-1734

1999

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Agoram B, Aoki K, Sameer Doshi, Gegg C, Jang G, Molineux G, Narhi L, Elliott S. 2008. Investigation of the effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: Nonerythropoietin receptor-mediated pathways may play a major role. J Pharm Sci 98: 2198–2211

Journal of pharmaceutical sciences, 2009-10, Vol.98 (10), p.3877-3877

2009

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Pegylation: Engineering Improved Biopharmaceuticals for Oncology

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates

Mono-N-terminal poly(ethylene glycol)–protein conjugates

The development of romiplostim for patients with immune thrombocytopenia

Development of romiplostim for the treatment of patients with chronic immune thrombocytopenia: from bench to bedside

The design and development of pegfilgrastim (PEG-rmetHuG-CSF, Neulasta)

Kinetics of Neutrophil Production in Normal and Neutropenic Animals during the Response to Filgrastim (r-metHu G-CSF) or Filgrastim SD/01 (PEG-r-metHu G-CSF)

Pegylation: engineering improved pharmaceuticals for enhanced therapy

Pegfilgrastim: using pegylation technology to improve neutropenia support in cancer patients

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

Repeated Hematopoietic Stem and Progenitor Cell Mobilization Without Depletion of the Bone Marrow Stem and Progenitor Cell Pool in Mice After Repeated Administration of Recombinant Murine G-CSF

Granulocyte colony-stimulating factors

Romiplostim promotes platelet recovery in a mouse model of multicycle chemotherapy-induced thrombocytopenia

Investigation of the effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: Nonerythropoietin receptor-mediated pathways may play a major role

Abstract 4109: Romiplostim promotes platelet recovery in a mouse model of multicycle chemotherapy-induced thrombocytopenia

Comparison of Epoetin Alfa and Darbepoetin Alfa Biological Activity under Different Administration Schedules in Normal Mice

Serum hepcidin but not prohepcidin may be an effective marker for anemia of inflammation (AI)

Pegylation: Engineering improved biopharmaceuticals for oncology: Pegfilgrastim: A new era in the management of chemotherapy-induced neutropenia

Phosphatidylinsoitol-3 Kinase Delta (PI3Kδ) Inhibitor AMG 319 Combined with Vincristine Enhances G2/M Arrest and Apoptotic Death in Neoplastic B Cells

Physiologic and pathologic consequences of granulocyte colony-stimulating factor deficiency: Hematopoietic growth factors

New Insights on Assessing Intra-Family Selectivity for Jak2 Inhibitors

Fetal Hemoglobin Expression Is Differentially Affected by Inhibition of the Proposed Dred Complex Constituents, LSD1 and DNMT1

A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans

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