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Phenotypic screening in cancer drug discovery — past, present and future

Nature reviews. Drug discovery, 2014-08, Vol.13 (8), p.588-602

2014

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A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays

PloS one, 2013-05, Vol.8 (5), p.e63583

2013

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Understanding the Pathophysiological Actions of Tau Oligomers: A Critical Review of Current Electrophysiological Approaches

Frontiers in molecular neuroscience, 2020-08, Vol.13, p.155-155

2020

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Opportunities and challenges in phenotypic drug discovery: an industry perspective

Nature reviews. Drug discovery, 2017-08, Vol.16 (8), p.531-543

2017

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Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2

eLife, 2024-03, Vol.12

2024

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The C291R Tau Variant Forms Different Types of Protofibrils

Frontiers in molecular neuroscience, 2020-03, Vol.13, p.39-39

2020

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Distinct Conformations, Aggregation and Cellular Internalization of Different Tau Strains

Frontiers in cellular neuroscience, 2019-07, Vol.13, p.296-296

2019

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Differential Localization of Glutamate Receptor Subunits at the Drosophila Neuromuscular Junction

The Journal of neuroscience, 2004-02, Vol.24 (6), p.1406-1415

2004

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Neural changes in the auditory cortex of awake guinea pigs after two tinnitus inducers: salicylate and acoustic trauma

Neuroscience, 2010-04, Vol.166 (4), p.1194-1209

2010

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Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and Plasticity

eNeuro, 2019-09, Vol.6 (5), p.ENEURO.0166-19.2019

2019

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arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity

Neuron (Cambridge, Mass.), 2011-06, Vol.70 (5), p.979-990

2011

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Turning the Light On in the Phenotypic Drug Discovery Black Box

Cell chemical biology, 2017-05, Vol.24 (5), p.545-547

Moffat, John G.

2017

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Effects of hearing aid fitting on the perceptual characteristics of tinnitus

Hearing research, 2009-08, Vol.254 (1), p.82-91

2009

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Early Stage Phase Separation in Pharmaceutical Solid Dispersion Thin Films under High Humidity: Improved Spatial Understanding Using Probe-Based Thermal and Spectroscopic Nanocharacterization Methods

Molecular pharmaceutics, 2013-03, Vol.10 (3), p.918-930

2013

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The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

Biochemical Society transactions, 2000-02, Vol.28 (2), p.33-41

2000

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Polymorph driven diversification of photosalient responses in a zinc(II) coordination complex

Chemical communications (Cambridge, England), 2024-07, Vol.60 (61), p.7890-7893

2024

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Phosphoproteome Profiling of the Receptor Tyrosine Kinase MuSK Identifies Tyrosine Phosphorylation of Rab GTPases

Molecular & cellular proteomics, 2022-04, Vol.21 (4), p.100221-100221, Article 100221

2022

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An AMPK-dependent regulatory pathway in tau-mediated toxicity

Biology open, 2017-10, Vol.6 (10), p.1434-1444

2017

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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

Biochemical journal, 2002-07, Vol.365 (Pt 2), p.405-416

2002

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Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations

Science translational medicine, 2012-12, Vol.4 (164), p.164ra161

2012

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Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in Acinetobacter baumannii and Escherichia coli

Journal of bacteriology, 2024-09

2024

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Preparation of stable tau oligomers for cellular and biochemical studies

Analytical biochemistry, 2019-02, Vol.566, p.67-74

2019

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Digitised exercise animations improve users motivation and understanding

Physiotherapy, 2015-05, Vol.101, p.e1182-e1183

2015

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Regulation of Neuronal Excitability through Pumilio-Dependent Control of a Sodium Channel Gene

The Journal of neuroscience, 2004-10, Vol.24 (40), p.8695-8703

2004

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Phenotypic screening in cancer drug discovery — past, present and future

A simple high-content cell cycle assay reveals frequent discrepancies between cell number and ATP and MTS proliferation assays

Understanding the Pathophysiological Actions of Tau Oligomers: A Critical Review of Current Electrophysiological Approaches

Opportunities and challenges in phenotypic drug discovery: an industry perspective

Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2

The C291R Tau Variant Forms Different Types of Protofibrils

Distinct Conformations, Aggregation and Cellular Internalization of Different Tau Strains

Differential Localization of Glutamate Receptor Subunits at the Drosophila Neuromuscular Junction

Neural changes in the auditory cortex of awake guinea pigs after two tinnitus inducers: salicylate and acoustic trauma

Introduction of Tau Oligomers into Cortical Neurons Alters Action Potential Dynamics and Disrupts Synaptic Transmission and Plasticity

arouser Reveals a Role for Synapse Number in the Regulation of Ethanol Sensitivity

Turning the Light On in the Phenotypic Drug Discovery Black Box

Effects of hearing aid fitting on the perceptual characteristics of tinnitus

Early Stage Phase Separation in Pharmaceutical Solid Dispersion Thin Films under High Humidity: Improved Spatial Understanding Using Probe-Based Thermal and Spectroscopic Nanocharacterization Methods

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

Polymorph driven diversification of photosalient responses in a zinc(II) coordination complex

Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

Phosphoproteome Profiling of the Receptor Tyrosine Kinase MuSK Identifies Tyrosine Phosphorylation of Rab GTPases

An AMPK-dependent regulatory pathway in tau-mediated toxicity

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations

Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in Acinetobacter baumannii and Escherichia coli

Preparation of stable tau oligomers for cellular and biochemical studies

Digitised exercise animations improve users motivation and understanding

Regulation of Neuronal Excitability through Pumilio-Dependent Control of a Sodium Channel Gene

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