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Discovery of High-Affinity Ligands of σ1 Receptor, ERG2, and Emopamil Binding Protein by Pharmacophore Modeling and Virtual Screening

Journal of medicinal chemistry, 2005-07, Vol.48 (15), p.4754-4764

2005

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Purification, Molecular Cloning, and Expression of the Mammalian sigma1-Binding Site

Proceedings of the National Academy of Sciences - PNAS, 1996-07, Vol.93 (15), p.8072-8077

1996

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Regulation of Melastatin, A TRP-Related Protein, through Interaction with a Cytoplasmic Isoform

Proceedings of the National Academy of Sciences - PNAS, 2001-09, Vol.98 (19), p.10692-10697

2001

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Mutations in the Δ7-sterol reductase gene in patients with the Smith–Lemli–Opitz syndrome

Proceedings of the National Academy of Sciences - PNAS, 1998-07, Vol.95 (14), p.8181-8186

1998

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High affinity of sigma1‐binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8–C7 isomerase

British journal of pharmacology, 1997-05, Vol.121 (1), p.1-6

1997

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7-Dehydrocholesterol–dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome

The Journal of clinical investigation, 2001-09, Vol.108 (6), p.905-915

2001

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Molecular cloning and expression of the human Δ7-sterol reductase

Proceedings of the National Academy of Sciences - PNAS, 1998-02, Vol.95 (4), p.1899-1902

1998

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Isolation of differentially expressed genes in NPM‐ALK‐positive anaplastic large cell lymphoma

British journal of haematology, 2002-09, Vol.118 (3), p.791-798

2002

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Identification of PK-A Phosphorylation Sites in the Carboxyl Terminus of L-Type Calcium Channel α1 Subunits

Biochemistry (Easton), 1996-07, Vol.35 (29), p.9400-9406

1996

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The mysteries of sigma receptors: new family members reveal a role in cholesterol synthesis

Trends in pharmacological sciences (Regular ed.), 1997-03, Vol.18 (3), p.67-70

1997

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Yeast Sterol C8−C7 Isomerase: Identification and Characterization of a High-Affinity Binding Site for Enzyme Inhibitors

Biochemistry (Easton), 1996-12, Vol.35 (51), p.16871-16878

1996

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Expression of the purported sigma1 (σ1) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy

Journal of chemical neuroanatomy, 2000-12, Vol.20 (3-4), p.375-387

2000

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Mutations in the Δ 7-sterol Reductase Gene in Patients with the Smith--Lemli--Opitz Syndrome

Proceedings of the National Academy of Sciences - PNAS, 1998-07, Vol.95 (14), p.8181-8186

1998

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High affinity of sigma 1 ‐binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C 8 –C 7 isomerase

British journal of pharmacology, 2009-02, Vol.121 (1), p.1-6

2009

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7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome

The Journal of clinical investigation, 2001-09, Vol.108 (6), p.905-915

2001

Volltextzugriff (PDF)

Molecular Cloning and Expression of the Human Δ 7-sterol Reductase

Proceedings of the National Academy of Sciences - PNAS, 1998-02, Vol.95 (4), p.1899-1902

1998

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Histidine77, Glutamic Acid81, Glutamic Acid123, Threonine126, Asparagine194, and Tryptophan197 of the Human Emopamil Binding Protein Are Required for in Vivo Sterol Δ8−Δ7 Isomerization

Biochemistry (Easton), 1999-01, Vol.38 (3), p.1119-1127

1999

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Genetic Defects in Postsqualene Cholesterol Biosynthesis

Trends in Endocrinology & Metabolism, 2000-04, Vol.11 (3), p.106-114

2000

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Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening

Journal of medicinal chemistry, 2005-07, Vol.48 (15), p.4754

2005

Volltextzugriff (PDF)

Discovery of High-Affinity Ligands of σ 1 Receptor, ERG2, and Emopamil Binding Protein by Pharmacophore Modeling and Virtual Screening

Journal of medicinal chemistry, 2005-07, Vol.48 (15), p.4754-4764

2005

Volltextzugriff (PDF)

Yeast Sterol C 8 −C 7 Isomerase: Identification and Characterization of a High-Affinity Binding Site for Enzyme Inhibitors

Biochemistry (Easton), 1996-12, Vol.35 (51), p.16871-16878

1996

Volltextzugriff (PDF)

Phenylalkylamine Ca2+ Antagonist Binding Protein

The Journal of biological chemistry, 1995-03, Vol.270 (13), p.7551-7557

1995

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Cloning of an emopamil-binding protein (EBP)-like protein that lacks sterol delta8-delta7 isomerase activity

Biochemical journal, 2003-08, Vol.374 (Pt 1), p.229-237

2003

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Cloning of an emopamil-binding protein (EBP)-like protein that lacks sterol Δ8-Δ7 isomerase activity

Biochemical journal, 2003-08, Vol.374 (1), p.229-237

2003

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Molecular genetics of the Smith-Lemli-Opitz syndrome and postsqualene sterol metabolism

Current opinion in lipidology, 1999-04, Vol.10 (2), p.123-132

1999

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Discovery of High-Affinity Ligands of σ1 Receptor, ERG2, and Emopamil Binding Protein by Pharmacophore Modeling and Virtual Screening

Purification, Molecular Cloning, and Expression of the Mammalian sigma1-Binding Site

Regulation of Melastatin, A TRP-Related Protein, through Interaction with a Cytoplasmic Isoform

Mutations in the Δ7-sterol reductase gene in patients with the Smith–Lemli–Opitz syndrome

High affinity of sigma1‐binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8–C7 isomerase

7-Dehydrocholesterol–dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome

Molecular cloning and expression of the human Δ7-sterol reductase

Isolation of differentially expressed genes in NPM‐ALK‐positive anaplastic large cell lymphoma

Identification of PK-A Phosphorylation Sites in the Carboxyl Terminus of L-Type Calcium Channel α1 Subunits

The mysteries of sigma receptors: new family members reveal a role in cholesterol synthesis

Yeast Sterol C8−C7 Isomerase: Identification and Characterization of a High-Affinity Binding Site for Enzyme Inhibitors

Expression of the purported sigma1 (σ1) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex as revealed using an antisense strategy

Mutations in the Δ 7-sterol Reductase Gene in Patients with the Smith--Lemli--Opitz Syndrome

High affinity of sigma 1 ‐binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C 8 –C 7 isomerase

7-Dehydrocholesterol-dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome

Molecular Cloning and Expression of the Human Δ 7-sterol Reductase

Histidine77, Glutamic Acid81, Glutamic Acid123, Threonine126, Asparagine194, and Tryptophan197 of the Human Emopamil Binding Protein Are Required for in Vivo Sterol Δ8−Δ7 Isomerization

Genetic Defects in Postsqualene Cholesterol Biosynthesis

Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening

Discovery of High-Affinity Ligands of σ 1 Receptor, ERG2, and Emopamil Binding Protein by Pharmacophore Modeling and Virtual Screening

Yeast Sterol C 8 −C 7 Isomerase: Identification and Characterization of a High-Affinity Binding Site for Enzyme Inhibitors

Phenylalkylamine Ca2+ Antagonist Binding Protein

Cloning of an emopamil-binding protein (EBP)-like protein that lacks sterol delta8-delta7 isomerase activity

Cloning of an emopamil-binding protein (EBP)-like protein that lacks sterol Δ8-Δ7 isomerase activity

Molecular genetics of the Smith-Lemli-Opitz syndrome and postsqualene sterol metabolism

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