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Biotin: From Nutrition to Therapeutics

The Journal of nutrition, 2017-08, Vol.147 (8), p.1487-1492

Mock, Donald M

2017

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Marginal Biotin Deficiency is Common in Normal Human Pregnancy and Is Highly Teratogenic in Mice

The Journal of nutrition, 2009, Vol.139 (1), p.154-157

Mock, Donald M

2009

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Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants

Pediatrics (Evanston), 2005-06, Vol.115 (6), p.1685

2005

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Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis

Neuropharmacology, 2016-11, Vol.110 (Pt B), p.644-653

2016

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Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities

Transfusion (Philadelphia, Pa.), 2011-05, Vol.51 (5), p.1047-1057

2011

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Autologous Infant and Allogeneic Adult Red Cells Demonstrate Similar Concurrent Post-Transfusion Survival in Very Low Birth Weight Neonates

The Journal of pediatrics, 2015-11, Vol.167 (5), p.1001-1006

2015

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Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS

Analytical and bioanalytical chemistry, 2011-11, Vol.401 (9), p.2805-2810

2011

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A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs

The AAPS journal, 2015-09, Vol.17 (5), p.1246-1254

2015

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Plasma concentration of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans

The American journal of clinical nutrition, 2010-12, Vol.92 (6), p.1399-1405

2010

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Adequate Intake of Biotin in Pregnancy: Why Bother?

The Journal of nutrition, 2014-12, Vol.144 (12), p.1885-1886

Mock, Donald M

2014

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Urinary Excretion of 3-Hydroxyisovaleric Acid and 3-Hydroxyisovaleryl Carnitine Increases in Response to a Leucine Challenge in Marginally Biotin-Deficient Humans

The Journal of nutrition, 2011-11, Vol.141 (11), p.1925-1930

2011

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Marginal biotin deficiency is teratogenic in mice and perhaps humans: a review of biotin deficiency during human pregnancy and effects of biotin deficiency on gene expression and enzyme activities in mouse dam and fetus

The Journal of nutritional biochemistry, 2005-07, Vol.16 (7), p.435-437

Mock, Donald M.

2005

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Pharmacokinetics and pharmacodynamics of MD1003 (high-dose biotin) in the treatment of progressive multiple sclerosis

Expert opinion on drug metabolism & toxicology, 2016-03, Vol.12 (3), p.327-344

2016

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Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood

The Journal of nutrition, 2005, Vol.135 (1), p.42-47

2005

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Marginal Biotin Deficiency Is Teratogenic in ICR Mice

The Journal of nutrition, 2003-08, Vol.133 (8), p.2519-2525

2003

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In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency

The Journal of nutrition, 2015-01, Vol.145 (1), p.32-40

2015

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Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge

The American journal of clinical nutrition, 2002-11, Vol.76 (5), p.1061-1068

2002

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Antibodies against biotin‐labeled red blood cells can shorten posttransfusion survival

Transfusion (Philadelphia, Pa.), 2022-04, Vol.62 (4), p.770-782

2022

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Target-mediated disposition population pharmacokinetics model of erythropoietin in premature neonates following multiple intravenous and subcutaneous dosing regimens

European journal of pharmaceutical sciences, 2019-10, Vol.138, p.105013-105013, Article 105013

2019

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Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities

Pediatric research, 2017-06, Vol.81 (6), p.905-910

2017

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A Novel Physiology-Based Mathematical Model to Estimate Red Blood Cell Lifespan in Different Human Age Groups

The AAPS journal, 2016-09, Vol.18 (5), p.1182-1191

2016

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Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs—a Case Example of Erythropoietin

The AAPS journal, 2018-11, Vol.21 (1), p.6-6, Article 6

2018

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Marginal Maternal Biotin Deficiency in CD-1 Mice Reduces Fetal Mass of Biotin-dependent Carboxylases

The Journal of nutrition, 2005-05, Vol.135 (5), p.973-977

2005

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Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell‐biotin dose

Transfusion (Philadelphia, Pa.), 2017-06, Vol.57 (6), p.1488-1496

2017

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In Vivo Biotin Supplementation at a Pharmacologic Dose Decreases Proliferation Rates of Human Peripheral Blood Mononuclear Cells and Cytokine Release

The Journal of nutrition, 2001-05, Vol.131 (5), p.1479-1484

2001

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Biotin: From Nutrition to Therapeutics

Marginal Biotin Deficiency is Common in Normal Human Pregnancy and Is Highly Teratogenic in Mice

Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants

Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis

Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities

Autologous Infant and Allogeneic Adult Red Cells Demonstrate Similar Concurrent Post-Transfusion Survival in Very Low Birth Weight Neonates

Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS

A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs

Plasma concentration of 3-hydroxyisovaleryl carnitine is an early and sensitive indicator of marginal biotin deficiency in humans

Adequate Intake of Biotin in Pregnancy: Why Bother?

Urinary Excretion of 3-Hydroxyisovaleric Acid and 3-Hydroxyisovaleryl Carnitine Increases in Response to a Leucine Challenge in Marginally Biotin-Deficient Humans

Marginal biotin deficiency is teratogenic in mice and perhaps humans: a review of biotin deficiency during human pregnancy and effects of biotin deficiency on gene expression and enzyme activities in mouse dam and fetus

Pharmacokinetics and pharmacodynamics of MD1003 (high-dose biotin) in the treatment of progressive multiple sclerosis

Biotin deficiency reduces expression of SLC19A3, a potential biotin transporter, in leukocytes from human blood

Marginal Biotin Deficiency Is Teratogenic in ICR Mice

In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency

Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge

Antibodies against biotin‐labeled red blood cells can shorten posttransfusion survival

Target-mediated disposition population pharmacokinetics model of erythropoietin in premature neonates following multiple intravenous and subcutaneous dosing regimens

Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities

A Novel Physiology-Based Mathematical Model to Estimate Red Blood Cell Lifespan in Different Human Age Groups

Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs—a Case Example of Erythropoietin

Marginal Maternal Biotin Deficiency in CD-1 Mice Reduces Fetal Mass of Biotin-dependent Carboxylases

Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell‐biotin dose

In Vivo Biotin Supplementation at a Pharmacologic Dose Decreases Proliferation Rates of Human Peripheral Blood Mononuclear Cells and Cytokine Release

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