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Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species

Frontiers in neuroscience, 2019-06, Vol.13, p.659

2019

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Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses

Frontiers in neuroscience, 2019-05, Vol.13, p.446

2019

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Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer’s disease

Journal of neurochemistry, 2011-05, Vol.117 (4), p.613-622

2011

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Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration

The Journal of clinical investigation, 2016-05, Vol.126 (5), p.1815-1833

2016

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Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

Nature medicine, 2013-04, Vol.19 (4), p.473-480

2013

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TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

Proceedings of the National Academy of Sciences - PNAS, 2016-09, Vol.113 (38), p.E5655-E5664

2016

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BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons

eLife, 2023-02, Vol.12

2023

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Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Neuron (Cambridge, Mass.), 2015-09, Vol.87 (5), p.963-975

2015

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PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)

Journal of Alzheimer's disease, 2017-01, Vol.60 (2), p.439

2017

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BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease

Neurobiology of disease, 2024-06, Vol.195, p.106502-106502, Article 106502

2024

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One at a time, live tracking of NGF axonal transport using quantum dots

Proceedings of the National Academy of Sciences - PNAS, 2007-08, Vol.104 (34), p.13666-13671

2007

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Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues

PloS one, 2015-07, Vol.10 (7), p.e0134861-e0134861

2015

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Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks

Journal of comparative neurology (1911), 2009-05, Vol.514 (3), p.240-258

2009

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Genetic dissection of the Down syndrome critical region

Human molecular genetics, 2015-11, Vol.24 (22), p.6540-6551

2015

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Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome

Scientific reports, 2020-12, Vol.10 (1), p.21323-21323, Article 21323

2020

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Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: Activation of β1 -adrenergic receptor by xamoterol as a potential cognitive enhancer

Neurobiology of disease, 2011-08, Vol.43 (2), p.397-413

2011

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The "Down Syndrome Critical Region" Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome

The Journal of neuroscience, 2009-05, Vol.29 (18), p.5938-5948

2009

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Illicium Sesquiterpenes: Divergent Synthetic Strategy and Neurotrophic Activity Studies

Chemistry : a European journal, 2013-05, Vol.19 (20), p.6398-6408

2013

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Synaptic and cognitive abnormalities in mouse models of down syndrome: Exploring genotype-phenotype relationships

Journal of comparative neurology (1911), 2007-10, Vol.504 (4), p.329-345

2007

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Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome

Neurobiology of disease, 2017-07, Vol.103, p.1-10

2017

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Hippocampal Long-Term Potentiation Suppressed by Increased Inhibition in the Ts65Dn Mouse, a Genetic Model of Down Syndrome

The Journal of neuroscience, 2004-09, Vol.24 (37), p.8153-8160

2004

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The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome

Genetics in medicine, 2009-09, Vol.11 (9), p.611-616

2009

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Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

Neurobiology of disease, 2012-02, Vol.45 (2), p.683-691

2012

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Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior

Frontiers in neuroscience, 2023-06, Vol.17, p.1202208-1202208

2023

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The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome

Frontiers in behavioral neuroscience, 2015-09, Vol.9, p.239-239

2015

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Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species

Exploring the Pathogenesis of Alzheimer Disease in Basal Forebrain Cholinergic Neurons: Converging Insights From Alternative Hypotheses

Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer’s disease

Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)

BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease

One at a time, live tracking of NGF axonal transport using quantum dots

Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues

Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks

Genetic dissection of the Down syndrome critical region

Detailed evaluation of the upper airway in the Dp(16)1Yey mouse model of Down syndrome

Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: Activation of β1 -adrenergic receptor by xamoterol as a potential cognitive enhancer

The "Down Syndrome Critical Region" Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome

Illicium Sesquiterpenes: Divergent Synthetic Strategy and Neurotrophic Activity Studies

Synaptic and cognitive abnormalities in mouse models of down syndrome: Exploring genotype-phenotype relationships

Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome

Hippocampal Long-Term Potentiation Suppressed by Increased Inhibition in the Ts65Dn Mouse, a Genetic Model of Down Syndrome

The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior

The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome

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