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Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients

Pharmacology & therapeutics (Oxford), 2016-10, Vol.166, p.84-95

2016

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Ninjin'yoeito, a traditional Japanese medicine, increases dopamine content in PC12 cells

Bioscience, biotechnology, and biochemistry, 2021-11, Vol.85 (11), p.2274-2280

2021

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Influence of aging on the behavioral phenotypes of C57BL/6J mice after social defeat

PloS one, 2019-09, Vol.14 (9), p.e0222076-e0222076

2019

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Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook

Current medicinal chemistry, 2018-03, Vol.25 (9), p.1036-1045

2018

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Cellular Pharmacological Effects of the Traditional Japanese Kampo Medicine Yokukansan on Brain Cells

Frontiers in pharmacology, 2017-09, Vol.8, p.655-655

2017

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The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice

Science signaling, 2022-01, Vol.15 (718), p.eabi5276

2022

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Ninjin'yoeito, a traditional Japanese Kampo medicine, suppresses the onset of anhedonia induced by dysfunction in the striatal dopamine receptor type 2-expressing medium spiny neurons

Neuroreport, 2021-07, Vol.32 (10), p.869-874

2021

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Ninjin'yoeito, a traditional Japanese medicine, attenuates age-related deficits of muscle performance, self-care motivation, and body temperature in C57BL/6 mice

Bioscience, biotechnology, and biochemistry, 2022-07, Vol.86 (7), p.895-901

2022

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In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes

Xenobiotica, 2022-05, Vol.52 (5), p.511-519

2022

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Yokukansankachimpihange, a traditional Japanese (Kampo) medicine, enhances the adaptation to circadian rhythm disruption by increasing endogenous melatonin levels

Journal of pharmacological sciences, 2020-11, Vol.144 (3), p.129-138

2020

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Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine

Gene, 2021-08, Vol.794, p.145752-145752, Article 145752

2021

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The effects of ninjin'yoeito on the electrophysiological properties of dopamine neurons in the ventral tegmental area/substantia nigra pars compacta and medium spiny neurons in the nucleus accumbens

Aging (Albany, NY.), 2022-06, Vol.14 (undefined), p.4634-4652

2022

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Expression of kinase-deficient MEK2 ameliorates Pelizaeus-Merzbacher disease phenotypes in mice

Biochemical and biophysical research communications, 2020-10, Vol.531 (4), p.445-451

2020

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Phospholipase D and phosphatidylinositol-4-phosphate 5-kinase 1 are involved in the regulation of oligodendrocyte morphological differentiation

Experimental cell research, 2021-08, Vol.405 (1), p.112654-112654, Article 112654

2021

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Comparison of the Effects of Yokukansan and Yokukansankachimpihange on Glutamate Uptake by Cultured Astrocytes and Glutamate-Induced Excitotoxicity in Cultured PC12 Cells

Evidence-based complementary and alternative medicine, 2019-01, Vol.2019 (2019), p.1-11

2019

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Yokukansan, a kampo medicine, protects PC12 cells from glutamate-induced death by augmenting gene expression of cystine/glutamate antiporter system Xc

PloS one, 2014-12, Vol.9 (12), p.e116275

2014

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Aging-related changes in the effects of social isolation on social behavior in rats

Physiology & behavior, 2011-01, Vol.102 (1), p.58-62

2011

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Specific binding and characteristics of 18β-glycyrrhetinic acid in rat brain

PloS one, 2014-04, Vol.9 (4), p.e95760-e95760

2014

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Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice

Journal of ethnopharmacology, 2015-05, Vol.166, p.23-30

2015

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Kamikihito Enhances Cognitive Functions and Reward-Related Behaviors of Aged C57BL/6J Mice in an Automated Behavioral Assay System

Frontiers in pharmacology, 2020-07, Vol.11, p.1037-1037

2020

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Basic Study of Drug-Drug Interaction between Memantine and the Traditional Japanese Kampo Medicine Yokukansan

Molecules (Basel, Switzerland), 2018-12, Vol.24 (1), p.115

2018

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Anxiolytic effect of a herbal medicine, yokukansan, in aged rats: Involvement of serotonergic and dopaminergic transmissions in the prefrontal cortex

Journal of ethnopharmacology, 2010-01, Vol.127 (1), p.70-76

2010

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Hypomyelinating Leukodystrophy 15 (HLD15)-Associated Mutation of EPRS1 Leads to Its Polymeric Aggregation in Rab7-Positive Vesicle Structures, Inhibiting Oligodendroglial Cell Morphological Differentiation

Polymers, 2021-03, Vol.13 (7), p.1074

2021

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Yokukansan and Yokukansankachimpihange Ameliorate Aggressive Behaviors in Rats with Cholinergic Degeneration in the Nucleus Basalis of Meynert

Frontiers in pharmacology, 2017-04, Vol.8, p.235-235

2017

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Hypomyelinating Leukodystrophy 7 (HLD7)-Associated Mutation of POLR3A Is Related to Defective Oligodendroglial Cell Differentiation, Which Is Ameliorated by Ibuprofen

Neurology international, 2021-12, Vol.14 (1), p.11-33

2021

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Neuropharmacological efficacy of the traditional Japanese Kampo medicine yokukansan and its active ingredients

Ninjin'yoeito, a traditional Japanese medicine, increases dopamine content in PC12 cells

Influence of aging on the behavioral phenotypes of C57BL/6J mice after social defeat

Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook

Cellular Pharmacological Effects of the Traditional Japanese Kampo Medicine Yokukansan on Brain Cells

The adaptor SH2B1 and the phosphatase PTP4A1 regulate the phosphorylation of cytohesin-2 in myelinating Schwann cells in mice

Ninjin'yoeito, a traditional Japanese Kampo medicine, suppresses the onset of anhedonia induced by dysfunction in the striatal dopamine receptor type 2-expressing medium spiny neurons

Ninjin'yoeito, a traditional Japanese medicine, attenuates age-related deficits of muscle performance, self-care motivation, and body temperature in C57BL/6 mice

In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes

Yokukansankachimpihange, a traditional Japanese (Kampo) medicine, enhances the adaptation to circadian rhythm disruption by increasing endogenous melatonin levels

Intron retention as a new pre-symptomatic marker of aging and its recovery to the normal state by a traditional Japanese multi-herbal medicine

The effects of ninjin'yoeito on the electrophysiological properties of dopamine neurons in the ventral tegmental area/substantia nigra pars compacta and medium spiny neurons in the nucleus accumbens

Expression of kinase-deficient MEK2 ameliorates Pelizaeus-Merzbacher disease phenotypes in mice

Phospholipase D and phosphatidylinositol-4-phosphate 5-kinase 1 are involved in the regulation of oligodendrocyte morphological differentiation

Comparison of the Effects of Yokukansan and Yokukansankachimpihange on Glutamate Uptake by Cultured Astrocytes and Glutamate-Induced Excitotoxicity in Cultured PC12 Cells

Yokukansan, a kampo medicine, protects PC12 cells from glutamate-induced death by augmenting gene expression of cystine/glutamate antiporter system Xc

Aging-related changes in the effects of social isolation on social behavior in rats

Specific binding and characteristics of 18β-glycyrrhetinic acid in rat brain

Yokukansan, a traditional Japanese medicine, decreases head-twitch behaviors and serotonin 2A receptors in the prefrontal cortex of isolation-stressed mice

Kamikihito Enhances Cognitive Functions and Reward-Related Behaviors of Aged C57BL/6J Mice in an Automated Behavioral Assay System

Basic Study of Drug-Drug Interaction between Memantine and the Traditional Japanese Kampo Medicine Yokukansan

Anxiolytic effect of a herbal medicine, yokukansan, in aged rats: Involvement of serotonergic and dopaminergic transmissions in the prefrontal cortex

Hypomyelinating Leukodystrophy 15 (HLD15)-Associated Mutation of EPRS1 Leads to Its Polymeric Aggregation in Rab7-Positive Vesicle Structures, Inhibiting Oligodendroglial Cell Morphological Differentiation

Yokukansan and Yokukansankachimpihange Ameliorate Aggressive Behaviors in Rats with Cholinergic Degeneration in the Nucleus Basalis of Meynert

Hypomyelinating Leukodystrophy 7 (HLD7)-Associated Mutation of POLR3A Is Related to Defective Oligodendroglial Cell Differentiation, Which Is Ameliorated by Ibuprofen

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